Product image of Olanzapine Accord Healthcare Ireland (Olanzapine) supplied by GNH India

Olanzapine Accord Healthcare Ireland

Active Ingredient:
Olanzapine
Origin:
EU

Olanzapine Accord Healthcare Ireland (Olanzapine)

Olanzapine, the active ingredient in Olanzapine Accord Healthcare Ireland, is an atypical antipsychotic presented as oral tablets for oral use. It is indicated for the treatment of schizophrenia and bipolar disorder in adult patients.
GNH India supplies Olanzapine Accord Healthcare Ireland as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare Ireland Limited

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Olanzapine is an atypical antipsychotic used in the management of several psychiatric disorders.

  • Schizophrenia: Reduces positive and negative symptoms and helps prevent relapse.
  • Bipolar I disorder (manic episodes): Controls acute mania and stabilises mood.
  • Maintenance treatment of schizophrenia: Supports long‑term symptom control and reduces hospitalisation risk.

How It Works

  • Olanzapine acts as an antagonist at dopamine D2 and serotonin 5‑HT2A receptors, with additional affinity for histamine H1, muscarinic, and adrenergic receptors. This multi‑receptor blockade modulates neurotransmission in cortical and limbic pathways, helping to normalise psychotic and mood symptoms.

Side Effects

Olanzapine may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Weight gain: increased appetite leading to body‑weight increase.
  • Sedation: drowsiness or feeling unusually sleepy.
  • Dry mouth: reduced salivary flow.
  • Constipation: slowed gastrointestinal motility.
  • Increased appetite: heightened desire for food.
  • Dizziness: light‑headed sensation, especially when standing.

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome: life‑threatening reaction with fever and muscle rigidity.
  • Agranulocytosis: severe reduction in white blood cells.
  • Hyperglycaemia/diabetes: marked elevation of blood glucose.
  • Tardive dyskinesia: involuntary, repetitive movements.
  • Myocarditis: inflammation of heart muscle.
  • Seizures: occurrence of convulsive episodes.

Precautions & Warnings

When prescribing olanzapine, clinicians should consider several safety measures.

  • Assess metabolic risk: monitor weight, glucose and lipid profiles regularly.
  • Evaluate cardiovascular status: check blood pressure and ECG when indicated.
  • Review psychiatric history: avoid abrupt discontinuation to prevent relapse.
  • Caution in elderly with dementia: increased mortality risk observed.
  • Pregnancy and lactation: use only if potential benefits outweigh risks.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in the original container.

Avoid Interactions

Olanzapine can interact with other medicines, altering its effectiveness or safety.

Major Interactions (Avoid)

  • CYP1A2 inhibitors (e.g., fluvoxamine): may raise olanzapine plasma levels.
  • Strong CYP3A4 inducers (e.g., rifampicin): can reduce olanzapine exposure.
  • CNS depressants (e.g., benzodiazepines): increase sedation and respiratory depression risk.
  • QT‑prolonging agents (e.g., certain antiarrhythmics): may enhance cardiac arrhythmia potential.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: additive orthostatic hypotension.
  • Antidiabetic drugs: olanzapine‑induced hyperglycaemia may require dose adjustment.
  • Lithium: heightened neurotoxicity risk.
  • Carbamazepine: moderate enzyme induction may lower olanzapine levels.
  • Smoking: induces CYP1A2, potentially decreasing drug concentration.

Frequently Asked Questions

Olanzapine Accord Healthcare Ireland is an atypical antipsychotic indicated for the treatment of schizophrenia, the management of acute manic episodes in bipolar I disorder, and for long‑term maintenance therapy to reduce relapse risk in these conditions.

Olanzapine works by blocking dopamine D2 and serotonin 5‑HT2A receptors while also affecting histamine, muscarinic and adrenergic receptors. This broad receptor antagonism helps to balance neurotransmitter activity in brain pathways that regulate mood, thought processes and perception.

The appropriate dose of olanzapine is determined individually by the prescribing clinician based on the patient’s diagnosis, severity of symptoms, prior treatment response and tolerability. Dosage adjustments are made according to clinical response and safety monitoring.

Olanzapine should be used during pregnancy only if the potential benefit justifies any potential risk to the fetus. Limited data are available for breastfeeding, and the drug is excreted in breast milk; therefore, a risk‑benefit assessment is required before continuation while nursing.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with first‑generation antipsychotics, olanzapine has a lower risk of extrapyramidal symptoms but a higher propensity for metabolic side effects such as weight gain and glucose elevation. Within the atypical class, its efficacy is comparable to risperidone and quetiapine, while its side‑effect profile differs in the degree of sedation and metabolic impact.

Olanzapine tablets should be stored at ambient temperature, preferably below 25 °C, in the original blister pack or container to protect from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

Olanzapine is administered orally as a tablet taken with or without food. The tablet should be swallowed whole with water and not chewed or crushed, unless a specific formulation permits alternative administration as directed by a healthcare professional.

Serious risks include neuroleptic malignant syndrome, severe hyperglycaemia or new‑onset diabetes, agranulocytosis, tardive dyskinesia, and cardiovascular events such as myocarditis. Patients should be monitored regularly for signs of these conditions, and treatment should be discontinued promptly if they occur.

Olanzapine is contraindicated in individuals with known hypersensitivity to the drug or any of its components. It should also be avoided in patients with severe central nervous system depression, uncontrolled narrow‑angle glaucoma, and in elderly patients with dementia‑related psychosis due to an increased risk of mortality.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Olanzapine

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT