Olanzapine Aurobindo
- Active Ingredient:
- Olanzapine
- Origin:
- EU
Olanzapine Aurobindo (Olanzapine)
Olanzapine, the active ingredient in Olanzapine Aurobindo, is a atypical antipsychotic presented as a tablet for oral use. It is primarily prescribed for the management of schizophrenia and bipolar I disorder in adults. GNH India supplies Olanzapine Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.
GNH India supplies Olanzapine Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.
Manufacturer / TM Owner
Aurobindo Pharma B.V.
Indications & Clinical Uses
Olanzapine Aurobindo is an atypical antipsychotic used in the treatment of several psychiatric conditions.
- Schizophrenia: reduces psychotic symptoms such as delusions, hallucinations and thought disorder.
- Bipolar I disorder (manic episodes): helps control mood swings and prevents escalation of manic symptoms.
- Schizoaffective disorder: alleviates both psychotic and mood components of the illness.
- Psychotic depression: augments antidepressant therapy by addressing residual psychotic features.
- Maintenance therapy: supports long‑term stability and reduces risk of relapse in chronic psychotic disorders.
How It Works
- Olanzapine acts as a potent antagonist at dopamine D2 and serotonin 5‑HT2A receptors, with additional activity at histamine H1, muscarinic M1‑M5 and adrenergic α1 receptors. This receptor profile modulates neurotransmission in brain pathways implicated in psychosis and mood regulation, thereby reducing psychotic symptoms and stabilizing mood.
Side Effects
Olanzapine may cause a range of adverse reactions, from mild to serious.
Common Side Effects
- Weight gain: increased appetite leading to gradual weight increase.
- Sedation: drowsiness or feeling of being unusually tired.
- Dry mouth: reduced salivation causing oral dryness.
- Constipation: slowed gastrointestinal motility.
- Elevated triglycerides: rise in blood lipid levels.
- Orthostatic hypotension: drop in blood pressure upon standing.
Serious or Rare Side Effects
- Neuroleptic malignant syndrome: rare, life‑threatening reaction with fever and muscle rigidity.
- Tardive dyskinesia: persistent involuntary movements, often of the face.
- Hyperglycaemia: significant rise in blood glucose, potentially precipitating diabetes.
- Seizures: increased risk of convulsive episodes.
- Agranulocytosis: severe reduction in white blood cells.
- Hepatotoxicity: liver enzyme elevations indicating possible liver injury.
Precautions & Warnings
When prescribing Olanzapine Aurobindo, clinicians should consider several safety aspects.
- Monitor metabolic parameters: regularly check weight, fasting glucose and lipid profile.
- Assess for cardiovascular risk: evaluate blood pressure and heart rate, especially in patients with pre‑existing hypertension.
- Screen for movement disorders: watch for early signs of tardive dyskinesia or extrapyramidal symptoms.
- Evaluate hepatic function: perform baseline liver function tests and repeat as needed.
- Use caution in the elderly: increased sensitivity to sedation and orthostatic hypotension.
- Store at ambient temperature: keep below 25°C in the original packaging, protected from moisture and direct sunlight.
Avoid Interactions
Olanzapine Aurobindo can interact with several other medicines, affecting its efficacy or safety.
Major Interactions (Avoid)
- Strong CYP1A2 inhibitors (e.g., fluvoxamine): may raise olanzapine plasma levels, increasing toxicity risk.
- CNS depressants (e.g., benzodiazepines, opioids): additive sedation and respiratory depression.
- Anticholinergic agents: may exacerbate dry mouth and constipation.
Moderate Interactions (Monitor Closely)
- CYP3A4 inducers (e.g., carbamazepine, rifampicin): may lower olanzapine concentrations, reducing therapeutic effect.
- Smoking: induces CYP1A2 and can decrease drug exposure.
- Lithium: combined use may increase the risk of neurotoxic effects.
Frequently Asked Questions
Olanzapine Aurobindo is an atypical antipsychotic indicated for the treatment of schizophrenia, bipolar I disorder (manic episodes), and related psychotic conditions. It helps control delusions, hallucinations, mood swings, and other symptoms associated with these psychiatric illnesses.
Olanzapine works by blocking dopamine D2 and serotonin 5‑HT2A receptors while also affecting histamine, muscarinic and adrenergic receptors. This combined antagonism modulates neurotransmitter activity in pathways that regulate mood, perception and cognition, thereby reducing psychotic and manic symptoms.
The appropriate dose of Olanzapine Aurobindo is determined by the prescribing clinician based on the patient’s condition, response to therapy and tolerability. Dosage may be adjusted over time and should follow the prescriber’s instructions and local prescribing guidelines.
Olanzapine should be used during pregnancy or lactation only if the potential benefits outweigh the risks. Limited data suggest possible fetal exposure and presence in breast milk, so clinicians must evaluate each case individually and discuss potential risks with the patient.
To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.
Compared with first‑generation antipsychotics, olanzapine has a lower risk of extrapyramidal symptoms but a higher propensity for metabolic side effects such as weight gain and glucose intolerance. Its broad receptor profile offers efficacy for both psychotic and mood symptoms, distinguishing it from many older agents.
Olanzapine Aurobindo tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the medication out of reach of children.
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