Olanzapine Eg (Olanzapine)

Olanzapine Eg is an atypical antipsychotic that modulates neurotransmission in several psychiatric disorders.

• Schizophrenia: reduces positive and negative symptoms and helps prevent relapse.
• Bipolar I disorder (manic phase): controls acute manic episodes and maintains mood stability.
• Schizoaffective disorder: alleviates psychotic features and mood disturbances.

• Olanzapine acts as a high‑affinity antagonist at dopamine D2 and serotonin 5‑HT2A receptors, with additional activity at histamine H1, muscarinic M1‑M5 and adrenergic α1 receptors. This receptor profile modulates dopaminergic and serotonergic pathways, contributing to antipsychotic and mood‑stabilising effects.

Olanzapine may cause a range of adverse reactions, most of which are dose‑dependent and reversible.

Common Side Effects

• Weight gain: increased appetite and caloric intake.
• Sedation: drowsiness or feeling of being slowed down.
• Dry mouth: reduced salivation.
• Constipation: slowed gastrointestinal motility.
• Elevated triglycerides: changes in lipid metabolism.
• Orthostatic hypotension: drop in blood pressure when standing.

Serious or Rare Side Effects

• Neuroleptic malignant syndrome: rare but life‑threatening reaction.
• Hyperglycaemia and new‑onset diabetes mellitus.
• Tardive dyskinesia: persistent involuntary movements.
• Seizures: lowered seizure threshold.
• Agranulocytosis: severe reduction in white‑blood cell count.
• Severe allergic reactions: anaphylaxis or skin rash.

When prescribing Olanzapine Eg, clinicians should consider several safety aspects.

• Metabolic monitoring: regularly assess weight, glucose and lipid levels.
• Cardiovascular assessment: monitor blood pressure and heart rate, especially at treatment start.
• CNS depression: advise patients not to operate machinery or drive if sedated.
• Pregnancy and lactation: evaluate risk‑benefit, use only if clearly needed.
• Elderly with dementia-related psychosis: increased risk of mortality.
• Store at below 25°C: keep in the original container, protect from moisture and light.

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