Product image of Olanzapine Lekam (Olanzapine) supplied by GNH India

Olanzapine Lekam

Active Ingredient:
Olanzapine
Origin:
EU

Olanzapine Lekam (Olanzapine)

Olanzapine, the active ingredient in Olanzapine Lekam, is an atypical antipsychotic presented as an oral tablet for oral use. It is employed in the management of schizophrenia and bipolar disorder in adult patients, helping to control psychotic symptoms and mood instability.

GNH India supplies Olanzapine Lekam as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and research institutions worldwide, adhering to EU quality standards and multiple regulatory jurisdictions. The company ensures batch‑to‑batch consistency, robust cold‑chain where required, and timely delivery to global partners.

Manufacturer / TM Owner

Przedsiębiorstwo Farmaceutyczne Lek-Am Sp. Z O.O.

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Indications & Clinical Uses

Olanzapine is an atypical antipsychotic used primarily in psychiatric disorders affecting dopamine and serotonin pathways.

  • Schizophrenia: reduction of acute psychotic symptoms and relapse prevention.
  • Bipolar I disorder (manic episodes): control of mania and rapid mood stabilization.
  • Maintenance treatment of bipolar disorder: prevention of recurrence of mood episodes.
  • Schizoaffective disorder: alleviation of both psychotic and mood symptoms.

How It Works

  • Olanzapine exerts its therapeutic effect by antagonizing dopamine D2 receptors and serotonin 5‑HT2A receptors, while also modulating activity at 5‑HT2C, H1 histamine, muscarinic and α1‑adrenergic receptors. This broad receptor profile reduces dopaminergic hyperactivity and balances serotonergic transmission, leading to improvement in psychotic and mood symptoms.

Side Effects

Common Side Effects

  • Weight gain: increased appetite leading to gradual weight increase.
  • Sedation: drowsiness or feeling of tiredness.
  • Dry mouth: reduced salivation.
  • Constipation: slowed gastrointestinal motility.
  • Dizziness: light‑headedness, especially when standing.
  • Increased appetite: heightened desire for food.

Serious or Rare Side Effects

  • Metabolic syndrome: significant changes in glucose and lipid metabolism.
  • Neuroleptic malignant syndrome: rare but life‑threatening reaction with fever and muscle rigidity.
  • Tardive dyskinesia: involuntary, repetitive movements.
  • Hyperglycemia: elevated blood sugar levels.
  • Agranulocytosis: severe reduction in white blood cells.
  • Seizures: occurrence of convulsive episodes.

Precautions & Warnings

Olanzapine requires careful monitoring due to its metabolic and neurological profile.

  • Monitor metabolic parameters: regular checks of weight, fasting glucose, and lipid profile.
  • Assess cardiovascular risk: observe blood pressure and ECG for QT changes.
  • Screen for movement disorders: watch for early signs of tardive dyskinesia.
  • Avoid abrupt discontinuation: taper the dose under medical supervision.
  • Store at ambient temperature: keep below 25°C in the original pack, protect from moisture.

Avoid Interactions

Olanzapine may interact with several drug classes, necessitating vigilance.

Major Interactions (Avoid)

  • CYP1A2 inhibitors: may increase olanzapine plasma concentrations.
  • CNS depressants: additive sedation and respiratory depression.
  • Anticholinergic agents: may exacerbate cognitive impairment.

Moderate Interactions (Monitor Closely)

  • CYP1A2 inducers: may reduce olanzapine effectiveness.
  • Lithium: increased risk of neurotoxicity.
  • Carbamazepine: may lower olanzapine plasma levels.

Frequently Asked Questions

Olanzapine Lekam contains the atypical antipsychotic olanzapine and is prescribed for the treatment of schizophrenia, bipolar I disorder (including manic episodes), and for maintenance therapy to prevent recurrence of mood episodes in bipolar disorder.

Olanzapine works by blocking dopamine D2 receptors and serotonin 5‑HT2A receptors, while also affecting other neurotransmitter systems such as 5‑HT2C, histamine H1, muscarinic, and α1‑adrenergic receptors. This broad antagonism helps to reduce psychotic symptoms and stabilize mood.

The appropriate dose of Olanzapine Lekam is individualized by the prescribing clinician based on the patient’s diagnosis, severity of symptoms, prior treatment response, and tolerability. Dosage adjustments are made under medical supervision.

Olanzapine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk, so breastfeeding is generally not recommended unless the infant’s need for the medication outweighs the possible adverse effects.

To order Olanzapine Lekam, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with other atypical antipsychotics such as risperidone, olanzapine generally offers strong efficacy for both psychotic and mood symptoms but has a higher propensity for metabolic side effects like weight gain and glucose intolerance. Choice of therapy depends on individual patient factors and risk‑benefit considerations.

Olanzapine Lekam tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and avoid storing in areas with high humidity.

Olanzapine Lekam is taken orally as a tablet. The tablet should be swallowed whole with water and can be taken with or without food, according to the prescribing clinician’s instructions.

Serious risks include metabolic syndrome (significant weight gain, hyperglycemia, dyslipidemia), neuroleptic malignant syndrome, tardive dyskinesia, and severe hyperglycemia. Patients should be monitored regularly for these conditions, and any concerning symptoms should be reported promptly.

Olanzapine Lekam is contraindicated in patients with known hypersensitivity to olanzapine or any excipients, and in individuals with severe central nervous system depression. Caution is advised in patients with uncontrolled diabetes, cardiovascular disease, or a history of neuroleptic malignant syndrome.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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