Product image of Olanzapine Milpharm (Olanzapine) supplied by GNH India

Olanzapine Milpharm

Active Ingredient:
Olanzapine
Origin:
EU

Olanzapine Milpharm (Olanzapine)

Olanzapine, the active ingredient in Olanzapine Milpharm, is an atypical antipsychotic presented as a tablet for oral use. It treats schizophrenia and bipolar disorder in adults, helping to control psychotic symptoms and stabilize mood. Olanzapine works by modulating dopamine and serotonin activity in the brain, which contributes to its therapeutic effects in a range of psychiatric conditions.

GNH India supplies Olanzapine Milpharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Milpharm Limited

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Indications & Clinical Uses

  • Olanzapine is an atypical antipsychotic that modulates dopamine and serotonin pathways in psychiatric disorders.
  • Schizophrenia: reduces positive and negative psychotic symptoms and improves overall functioning.
  • Bipolar disorder (manic episodes): stabilises mood and prevents recurrence of manic symptoms.
  • Schizoaffective disorder: alleviates both psychotic and mood components of the illness.

How It Works

  • Olanzapine acts as an antagonist at dopamine D2 receptors and serotonin 5‑HT2A receptors, thereby decreasing dopaminergic neurotransmission and modulating serotonergic activity. It also exhibits affinity for histamine H1, muscarinic M1‑M5, and adrenergic α1 receptors, contributing to its clinical profile and side‑effect spectrum.

Side Effects

Olanzapine may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Weight gain: increased appetite leading to gradual weight increase.
  • Sedation: drowsiness or feeling unusually tired.
  • Dry mouth: reduced salivation causing discomfort.
  • Constipation: slowed gastrointestinal motility.

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome: rare but life‑threatening reaction with fever and muscle rigidity.
  • Agranulocytosis: severe drop in white blood cells.
  • Tardive dyskinesia: involuntary movements after prolonged use.
  • Severe hyperglycemia: marked increase in blood glucose levels.
  • Myocarditis: inflammation of the heart muscle.

Precautions & Warnings

  • When prescribing Olanzapine, clinicians should consider several safety measures.
  • Monitor metabolic parameters: regularly check weight, fasting glucose, and lipid profile.
  • Assess extrapyramidal symptoms: watch for tremor, rigidity, or abnormal movements.
  • Evaluate cardiovascular status: be aware of orthostatic hypotension and possible QT prolongation.
  • Review hepatic function: dose adjustment may be required in liver impairment.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Olanzapine can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP1A2 inhibitors (e.g., fluvoxamine): may increase olanzapine plasma levels.
  • Carbamazepine: enzyme induction can reduce olanzapine exposure.
  • Concurrent antipsychotics: additive risk of QT prolongation and sedation.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: additive hypotensive effect may occur.
  • Anticholinergic agents: increased anticholinergic burden can worsen side effects.
  • Glucose‑lowering drugs: risk of hyperglycemia may be heightened.

Frequently Asked Questions

Olanzapine Milpharm is an oral atypical antipsychotic indicated for the treatment of schizophrenia and bipolar disorder in adults. It helps control psychotic symptoms such as hallucinations and delusions, and stabilises mood during manic episodes.

Olanzapine works by blocking dopamine D2 receptors and serotonin 5‑HT2A receptors, which reduces dopaminergic activity and modulates serotonergic signalling. This dual antagonism helps to alleviate psychotic symptoms and improve mood regulation.

The appropriate dose of Olanzapine Milpharm is determined by the prescribing clinician based on the patient’s condition, response, and tolerability. Dosage may be adjusted over time to achieve optimal therapeutic effect.

Safety of olanzapine in pregnancy or lactation has not been fully established. Clinicians should weigh potential benefits against risks and consider alternative therapies when treating pregnant or nursing individuals.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Olanzapine is an atypical antipsychotic with strong affinity for both dopamine and serotonin receptors, offering efficacy in both psychotic and mood symptoms. Compared with typical antipsychotics, it has a lower risk of extrapyramidal side effects but a higher propensity for metabolic changes such as weight gain and glucose elevation.

Olanzapine Milpharm should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the tablets from moisture, direct sunlight and excessive heat to maintain potency.

Olanzapine Milpharm is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with water and not chewed or crushed unless specifically instructed by a healthcare professional.

Serious risks include neuroleptic malignant syndrome, agranulocytosis, severe hyperglycemia, and tardive dyskinesia. Patients should be monitored regularly for signs of these conditions, and any concerning symptoms should prompt immediate medical evaluation.

Olanzapine is contraindicated in individuals with known hypersensitivity to olanzapine or any of its excipients. Caution is advised for patients with uncontrolled diabetes, severe cardiovascular disease, or a history of neuroleptic malignant syndrome.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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