Product image of Olanzapine Neuraxpharm (Olanzapine) supplied by GNH India

Olanzapine Neuraxpharm

Active Ingredient:
Olanzapine
Origin:
EU

Olanzapine Neuraxpharm (Olanzapine)

Olanzapine, the active ingredient in Olanzapine Neuraxpharm, is an atypical antipsychotic presented as an oral formulation for oral use. It treats schizophrenia and bipolar disorder in adult patients.
GNH India supplies Olanzapine Neuraxpharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Neuraxpharm Arzneimittel Gmbh

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Indications & Clinical Uses

Olanzapine Neuraxpharm acts on dopaminergic and serotonergic pathways to manage serious mental health conditions.

  • Schizophrenia: reduces psychotic symptoms such as delusions, hallucinations and thought disorder.
  • Bipolar disorder (manic episodes): stabilises mood and diminishes mania-related agitation.
  • Maintenance therapy: helps prevent relapse of psychotic or mood episodes in chronic patients.

How It Works

  • Olanzapine exerts its therapeutic effect primarily by antagonising dopamine D2 receptors and serotonin 5‑HT2A receptors, while also interacting with histamine H1, muscarinic and adrenergic receptors. This receptor profile modulates neurotransmission, leading to reduced psychotic symptoms and mood stabilization.

Side Effects

Common side effects are typically mild to moderate and may resolve with continued therapy.

Common Side Effects

  • Weight gain: increased appetite and body mass.
  • Sedation: drowsiness or reduced alertness.
  • Dry mouth: reduced salivary flow.
  • Constipation: slowed gastrointestinal motility.

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome: life‑threatening reaction with fever and muscle rigidity.
  • Agranulocytosis: severe drop in white blood cells.
  • Tardive dyskinesia: involuntary, repetitive movements.

Precautions & Warnings

Olanzapine requires careful monitoring due to metabolic and neurological considerations.

  • Metabolic monitoring: regularly assess weight, glucose and lipid levels.
  • Cardiovascular assessment: evaluate for orthostatic hypotension and QT prolongation.
  • Seizure risk: use cautiously in patients with a history of seizures.
  • Elderly caution: avoid in patients with dementia‑related psychosis due to increased mortality risk.
  • Discontinuation: taper gradually under medical supervision to prevent withdrawal.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Olanzapine may interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Other dopamine antagonists: may increase risk of extrapyramidal symptoms.
  • Strong CYP1A2 inhibitors (e.g., fluvoxamine): can raise olanzapine plasma concentrations.
  • CNS depressants (e.g., benzodiazepines): may enhance sedation and respiratory depression.

Moderate Interactions (Monitor Closely)

  • CYP2D6 substrates (e.g., metoprolol): may require dose adjustment.
  • Anticholinergic agents: additive anticholinergic burden may worsen dry mouth or constipation.
  • Smoking: induces CYP1A2, potentially reducing olanzapine levels.

Frequently Asked Questions

Olanzapine Neuraxpharm is prescribed for the management of schizophrenia and for acute manic episodes of bipolar disorder. It may also be used as maintenance therapy to help prevent relapse of psychotic or mood symptoms in patients with chronic disease.

Olanzapine works by blocking dopamine D2 receptors and serotonin 5‑HT2A receptors, which reduces excessive dopaminergic and serotonergic activity linked to psychosis and mood instability. Its additional activity at histamine, muscarinic and adrenergic receptors contributes to its overall therapeutic profile.

The appropriate dose of Olanzapine Neuraxpharm is determined by the prescribing clinician based on the individual’s diagnosis, severity of symptoms, age, renal and hepatic function, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for olanzapine in pregnancy and lactation are limited. The drug should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers will evaluate each case and discuss alternatives when appropriate.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Olanzapine is known for strong efficacy in controlling psychotic and manic symptoms, often with a higher propensity for metabolic side effects such as weight gain and glucose elevation compared with some other atypicals. Clinicians balance efficacy against tolerability when selecting the most suitable agent for each patient.

Olanzapine Neuraxpharm should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, excessive heat and direct sunlight to maintain its stability and potency throughout its shelf life.

Olanzapine Neuraxpharm is taken orally, usually as a tablet or film‑coated tablet, with or without food. The exact administration schedule—once daily or divided doses—depends on the prescriber’s recommendation and the patient’s clinical response.

Serious risks include neuroleptic malignant syndrome, agranulocytosis, severe hyperglycemia, and tardive dyskinesia. Patients should be monitored regularly for signs of these conditions, and any sudden changes in health should be reported to a healthcare professional immediately.

Olanzapine is contraindicated in patients with known hypersensitivity to olanzapine or any of its excipients. It should be avoided in individuals with severe central nervous system depression, uncontrolled narrow‑angle glaucoma, or in elderly patients with dementia‑related psychosis due to an increased risk of mortality.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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