Product image of Olanzapine Sandoz (Olanzapine) supplied by GNH India

Olanzapine Sandoz

Active Ingredient:
Olanzapine
Origin:
EU

Olanzapine Sandoz (Olanzapine)

Olanzapine, the active ingredient in Olanzapine Sandoz, is an atypical antipsychotic presented as an oral tablet for oral use. It is prescribed for the management of schizophrenia and bipolar I disorder in adult patients.

GNH India supplies Olanzapine Sandoz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz Ltd

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Indications & Clinical Uses

Olanzapine is an atypical antipsychotic used in the treatment of major psychiatric disorders.

  • Schizophrenia: reduces psychotic symptoms such as delusions, hallucinations and thought disorder.
  • Bipolar I disorder (manic episodes): controls acute manic symptoms and stabilises mood.
  • Maintenance therapy: helps prevent relapse of schizophrenia or bipolar disorder when used long‑term.

How It Works

  • Olanzapine acts as an antagonist at dopamine D2 and serotonin 5‑HT2A receptors, with additional affinity for histamine H1, muscarinic and adrenergic receptors. This receptor profile modulates dopaminergic and serotonergic neurotransmission, contributing to its antipsychotic and mood‑stabilising effects.

Side Effects

Olanzapine may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Weight gain: increased body mass and appetite.
  • Sedation: drowsiness or reduced alertness.
  • Dry mouth: reduced salivation.
  • Constipation: slowed gastrointestinal motility.

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome: life‑threatening reaction with fever and muscle rigidity.
  • Agranulocytosis: severe reduction in white blood cells, increasing infection risk.

Precautions & Warnings

When prescribing Olanzapine, clinicians should consider several safety measures.

  • Metabolic monitoring: regularly assess weight, glucose and lipid levels.
  • Cardiovascular assessment: evaluate for orthostatic hypotension and QT prolongation.
  • Seizure risk: use cautiously in patients with a history of seizures.
  • Elderly patients: avoid in dementia‑related psychosis due to increased mortality risk.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Olanzapine can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • CYP1A2 inhibitors (e.g., fluvoxamine): may increase olanzapine plasma levels.
  • CNS depressants (e.g., benzodiazepines): additive sedation and respiratory depression.
  • Anticholinergic agents: heightened anticholinergic burden.

Moderate Interactions (Monitor Closely)

  • CYP2D6 inhibitors (e.g., paroxetine): may modestly raise olanzapine concentrations.
  • Antihypertensives: potential for enhanced hypotensive effect.

Frequently Asked Questions

Olanzapine Sandoz is indicated for the treatment of schizophrenia and bipolar I disorder, including acute manic episodes and maintenance therapy to prevent relapse in adult patients.

Olanzapine blocks dopamine D2 and serotonin 5‑HT2A receptors while also affecting histamine, muscarinic and adrenergic receptors. This combined antagonism balances neurotransmitter activity, reducing psychotic symptoms and stabilising mood.

The appropriate dose of Olanzapine Sandoz is determined by the prescribing clinician based on the patient’s condition, response, and tolerability. Dosage adjustments are made according to clinical guidelines.

Safety data for Olanzapine Sandoz in pregnancy and lactation are limited. Clinicians should weigh potential benefits against risks and consider alternative therapies when treating pregnant or nursing women.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Olanzapine Sandoz belongs to the atypical antipsychotic class, offering strong efficacy for both positive and negative symptoms of schizophrenia and mood stabilization in bipolar disorder. Compared with some older agents, it has a lower risk of extrapyramidal symptoms but a higher propensity for metabolic side effects.

Olanzapine Sandoz should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and extreme heat to maintain potency.

Olanzapine Sandoz is taken orally, usually as a tablet, with or without food. Patients should follow the prescribing clinician’s instructions regarding timing and any necessary dose adjustments.

The most serious risks include neuroleptic malignant syndrome, agranulocytosis, severe hyperglycaemia, and significant weight gain that can lead to metabolic syndrome. Prompt medical attention is required if any of these symptoms appear.

Olanzapine Sandoz is contraindicated in patients with known hypersensitivity to olanzapine or any of its excipients, and it should be avoided in individuals with severe central nervous system depression or uncontrolled narrow‑angle glaucoma.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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