Product image of Olanzin (Olanzapine) supplied by GNH India

Olanzin

Active Ingredient:
Olanzapine
Origin:
EU

Olanzin (Olanzapine)

Olanzapine, the active ingredient in Olanzin, is an atypical antipsychotic presented as an oral tablet for oral use. It is prescribed for the management of schizophrenia and bipolar disorder, particularly manic episodes, in adult patients.

GNH India supplies Olanzin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Actavis Group Ptc Ehf.

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Indications & Clinical Uses

Olanzapine is an atypical antipsychotic used to treat major psychiatric conditions by modulating dopamine and serotonin pathways.

  • Schizophrenia: reduces psychotic symptoms such as hallucinations, delusions, and thought disorder.
  • Bipolar disorder (manic episodes): stabilises mood and diminishes manic symptoms, helping prevent relapse.

How It Works

  • Olanzapine acts as an antagonist at dopamine D2 and serotonin 5‑HT2A receptors, while also influencing other neurotransmitter receptors including histamine H1, muscarinic, and adrenergic sites. This receptor profile reduces dopaminergic overactivity and modulates serotonergic transmission, contributing to antipsychotic and mood‑stabilising effects.

Side Effects

Olanzapine may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Weight gain: increased appetite leading to gradual weight increase.
  • Sedation: drowsiness or feeling unusually sleepy.
  • Dry mouth: reduced salivation causing oral discomfort.
  • Constipation: slowed gastrointestinal motility.
  • Elevated triglycerides: changes in lipid metabolism.
  • Orthostatic hypotension: dizziness upon standing.

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome: life‑threatening reaction with fever and muscle rigidity.
  • Agranulocytosis: severe reduction in white blood cells.
  • Hyperglycaemia/diabetes mellitus: significant rise in blood glucose levels.
  • Tardive dyskinesia: involuntary, repetitive movements.
  • Seizures: increased risk of convulsive episodes.
  • Hepatic dysfunction: abnormal liver enzyme elevations.

Precautions & Warnings

Before initiating Olanzapine, clinicians should consider several safety factors.

  • Cardiovascular monitoring: assess blood pressure and heart rate regularly.
  • Metabolic screening: check fasting glucose, lipid profile, and weight at baseline and periodically.
  • CNS depression: avoid alcohol or other sedatives that may enhance drowsiness.
  • Pregnancy and lactation: use only if potential benefit justifies potential risk; data are limited.
  • Elderly patients with dementia: increased risk of mortality; avoid unless clearly indicated.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Olanzapine can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin): may increase olanzapine plasma levels, raising toxicity risk.
  • CNS depressants (e.g., benzodiazepines, opioids): can potentiate sedation and respiratory depression.

Moderate Interactions (Monitor Closely)

  • CYP1A2 inducers (e.g., smoking, carbamazepine): may reduce olanzapine concentrations, diminishing therapeutic effect.
  • Anticholinergic agents: may exacerbate dry mouth and constipation.
  • Antihypertensives: orthostatic hypotension may be enhanced.
  • Lithium: combined use may increase risk of neurotoxicity.
  • Antidiabetic drugs: monitor glucose as olanzapine can worsen hyperglycaemia.

Frequently Asked Questions

Olanzin, containing olanzapine, is prescribed for adults with schizophrenia to control psychotic symptoms and for bipolar disorder during manic episodes to stabilise mood and prevent relapse.

Olanzapine blocks dopamine D2 and serotonin 5‑HT2A receptors while also affecting histamine, muscarinic, and adrenergic receptors. This combined antagonism reduces dopaminergic overactivity and balances serotonin signaling, which helps alleviate psychosis and mood disturbances.

The appropriate dose of Olanzin is determined by the prescribing clinician based on the patient’s condition, response, and tolerability. Dosage adjustments are made individually and should follow the prescriber’s instructions.

Safety data for olanzapine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To request Olanzin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Olanzin (olanzapine) is an atypical antipsychotic with a broader receptor profile than many first‑generation agents, offering effective control of both positive and negative schizophrenia symptoms and mood stabilization in bipolar disorder. Compared with some atypicals, it may have a higher propensity for metabolic side effects such as weight gain and glucose elevation.

Olanzin should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and extreme heat to maintain its stability.

Olanzin is taken orally, usually as a tablet, with or without food. The exact administration schedule is set by the prescriber, who will advise on timing and any specific instructions related to meals.

Serious risks include neuroleptic malignant syndrome, agranulocytosis, significant hyperglycaemia or new‑onset diabetes, and tardive dyskinesia. Patients should be monitored regularly for signs of these conditions, and any concerning symptoms should prompt immediate medical evaluation.

Olanzin is contraindicated in individuals with known hypersensitivity to olanzapine or any component of the formulation. Caution is advised for patients with severe hepatic impairment, uncontrolled diabetes, or a history of neuroleptic malignant syndrome.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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