Product image of Olartan-Plus (Olmesartan Medoxomil, Hydrochlorothiazide) supplied by GNH India

Olartan-Plus

Active Ingredient:
Olmesartan Medoxomil, Hydrochlorothiazide
Origin:
EU

Olartan-Plus (Olmesartan Medoxomil, Hydrochlorothiazide)

Olmesartan Medoxomil, the active ingredient in Olartan-Plus, is a Angiotensin II receptor blocker (ARB) presented as an oral tablet for oral use. It treats hypertension in adult patients and helps lower cardiovascular risk.

GNH India supplies Olartan-Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

Olartan-Plus, an ARB‑thiazide combination, is used to manage elevated blood pressure within the hypertension therapeutic area.

  • Hypertension: reduces systolic and diastolic blood pressure, improving overall cardiovascular control.

How It Works

  • Olmesartan medoxomil selectively blocks AT1 receptors, preventing angiotensin II from causing vasoconstriction and aldosterone release. Hydrochlorothiazide acts on the distal convoluted tubule to inhibit NaCl reabsorption, increasing urinary excretion of sodium and water, thereby lowering plasma volume and blood pressure.

Side Effects

Adverse reactions may occur with Olartan-Plus and are categorized by frequency.

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Fatigue
  • Increased urination
  • Electrolyte disturbances (e.g., low potassium)
  • Mild gastrointestinal upset

Serious or Rare Side Effects

  • Severe hypotension
  • Acute kidney injury
  • Hyperkalemia
  • Angioedema
  • Severe electrolyte imbalance (e.g., hyponatremia)
  • Allergic skin reactions (e.g., rash, Stevens‑Johnson syndrome)

Precautions & Warnings

Patients should be aware of specific safety considerations before using Olartan-Plus.

  • Pregnancy: contraindicated in pregnancy (Category D) due to risk of fetal toxicity.
  • Renal impairment: monitor kidney function and adjust therapy as needed.
  • Electrolyte balance: check serum potassium and sodium regularly.
  • Concomitant diuretics: assess for additive hypotensive effects.
  • Gout: may increase serum uric acid; monitor in susceptible individuals.
  • Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture and light.

Avoid Interactions

Olartan-Plus may interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Dual renin‑angiotensin system blockade (e.g., ACE inhibitors, other ARBs) – risk of severe hypotension and renal failure.
  • Potassium‑sparing diuretics or supplements – risk of hyperkalemia.
  • Lithium – increased lithium levels, potential toxicity.

Moderate Interactions (Monitor Closely)

  • NSAIDs – may reduce antihypertensive effect and impair renal function.
  • Antidiabetic agents – may enhance hypoglycemic effect.
  • CYP450 inhibitors (e.g., ketoconazole) – may increase olmesartan levels.
  • Loop diuretics – additive diuretic effect, monitor electrolytes.

Frequently Asked Questions

Olartan-Plus is prescribed to lower high blood pressure (hypertension) in adult patients. By combining an angiotensin II receptor blocker with a thiazide diuretic, it helps achieve better blood pressure control and reduces cardiovascular risk.

Olmesartan Medoxomil blocks AT1 receptors, preventing angiotensin II from causing vasoconstriction and aldosterone release. This leads to relaxed blood vessels and reduced fluid retention, contributing to lower blood pressure.

The dosage of Olartan-Plus is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and other individual factors. No fixed dose is provided here.

Olartan-Plus is classified as Pregnancy Category D, indicating potential risk to the fetus and should be avoided during pregnancy. Safety during breastfeeding has not been established, so use is generally not recommended.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Olartan-Plus combines an ARB with a thiazide diuretic, offering dual mechanisms that can provide more effective blood pressure reduction than monotherapy with either class alone. It is often preferred when a single‑pill regimen is desired for better adherence.

Olartan-Plus tablets should be stored at ambient temperature, below 25 °C, in the original packaging. Protect them from moisture, excessive heat, and direct sunlight to maintain product stability.

Olartan-Plus is taken orally, usually once daily, with or without food, as directed by the healthcare professional. Swallow the tablet whole with a glass of water.

Serious risks include severe hypotension, acute kidney injury, hyperkalemia, and angioedema. Patients should be monitored for signs of these conditions, especially when initiating therapy or adjusting doses.

Olartan-Plus should not be used by individuals with known hypersensitivity to olmesartan, hydrochlorothiazide, or any component of the formulation, as well as pregnant women. Caution is also advised for patients with severe renal impairment or electrolyte disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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