Product image of Olastazen (Olanzapine) supplied by GNH India

Olastazen

Active Ingredient:
Olanzapine
Origin:
EU

Olastazen (Olanzapine)

Olanzapine, the active ingredient in Olastazen, is an atypical antipsychotic presented as an oral tablet for oral use. It is employed in the management of schizophrenia and bipolar disorder, helping to control psychotic symptoms and mood instability in adult patients.

GNH India supplies Olastazen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation to support import and distribution across multiple regions. Customers benefit from reliable lead times and dedicated technical support throughout the supply chain.

Manufacturer / TM Owner

Heremco

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Indications & Clinical Uses

Olanzapine is an atypical antipsychotic used to treat disorders involving dopamine and serotonin dysregulation.

  • Schizophrenia: reduces delusions, hallucinations, and thought disorder.
  • Bipolar disorder (manic episodes): stabilizes mood and diminishes manic symptoms.
  • Schizoaffective disorder: helps control both psychotic and mood components.

How It Works

  • Olanzapine exerts its therapeutic effect primarily by antagonizing dopamine D2 receptors and serotonin 5‑HT2A receptors, thereby modulating dopaminergic and serotonergic neurotransmission. It also shows affinity for histamine H1, muscarinic, and adrenergic receptors, contributing to its clinical profile and side‑effect spectrum.

Side Effects

Olanzapine may be associated with a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Weight gain: increased appetite leading to gradual weight increase.
  • Sedation: drowsiness or feeling unusually sleepy.
  • Dry mouth: reduced salivation causing oral discomfort.
  • Constipation: slowed gastrointestinal motility.

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome: life‑threatening reaction with fever and muscle rigidity.
  • Agranulocytosis: severe reduction in white blood cells.
  • Severe hyperglycemia: marked elevation of blood glucose levels.

Precautions & Warnings

When prescribing olanzapine, clinicians should consider several safety measures.

  • Dose titration: start low and adjust based on response and tolerability.
  • Metabolic monitoring: regularly assess weight, glucose, and lipid profiles.
  • CNS effects: monitor for excessive sedation or orthostatic hypotension.
  • Elderly patients: use with caution due to increased sensitivity to side effects.
  • Pregnancy and lactation: evaluate risk‑benefit as safety data are limited.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Olanzapine can interact with other medicines, requiring attention to potential changes in drug levels or additive effects.

Major Interactions (Avoid)

  • CYP1A2 inhibitors (e.g., fluvoxamine): may increase olanzapine plasma concentrations.
  • CNS depressants (e.g., benzodiazepines, alcohol): additive sedation and respiratory depression.
  • Anticholinergic agents: may exacerbate anticholinergic burden.

Moderate Interactions (Monitor Closely)

  • CYP2D6 inhibitors (e.g., paroxetine): may modestly raise olanzapine levels.
  • Smoking cessation: induces CYP1A2, potentially lowering olanzapine exposure.
  • Lithium: monitor for additive neurotoxic effects.

Frequently Asked Questions

Olastazen contains olanzapine, an atypical antipsychotic indicated for the treatment of schizophrenia and bipolar disorder. It helps control psychotic symptoms such as delusions and hallucinations, and stabilizes mood during manic episodes.

Olanzapine works by blocking dopamine D2 receptors and serotonin 5‑HT2A receptors, which reduces dopamine and serotonin activity in the brain. This modulation of neurotransmission alleviates psychotic symptoms and mood disturbances.

The appropriate dose of Olastazen is determined by the prescribing clinician based on the patient’s condition, response, and tolerability. Dosage may be adjusted over time, and patients should follow the prescriber’s instructions exactly.

Safety data for olanzapine in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used if the potential benefits outweigh the risks, after consultation with a healthcare professional.

To order Olastazen, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Compared with typical antipsychotics, olanzapine has a lower risk of extrapyramidal symptoms but a higher propensity for metabolic effects such as weight gain and glucose elevation. Relative to other atypicals like risperidone, it may offer stronger sedation and greater efficacy for certain mood symptoms.

Olastazen should be stored at ambient temperature below 25 °C. Keep the tablets in the original packaging, protect them from moisture and light, and avoid storing in humid or excessively hot environments.

Olastazen is taken orally as a tablet, usually once daily. It can be swallowed with or without food, and patients should not crush or chew the tablet unless specifically instructed by a healthcare professional.

Serious risks include neuroleptic malignant syndrome, severe hyperglycemia, and agranulocytosis. Patients should be monitored for fever, muscle rigidity, rapid changes in blood sugar, or signs of infection, and seek immediate medical attention if these occur.

Olastazen should be avoided in individuals with known hypersensitivity to olanzapine or any excipients, those with severe central nervous system depression, and patients for whom metabolic complications would pose a significant risk. A thorough medical review is required before initiation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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