Product image of Olectan Hct (Olmesartan Medoxomil, Amlodipine, Hydrochlorothiazide) supplied by GNH India

Olectan Hct

Active Ingredient:
Olmesartan Medoxomil, Amlodipine, Hydrochlorothiazide
Origin:
EU

Olectan Hct (Olmesartan Medoxomil, Amlodipine, Hydrochlorothiazide)

Olmesartan medoxomil, amlodipine and hydrochlorothiazide, the active ingredients in Olectan Hct, are an angiotensin II receptor blocker, calcium channel blocker and thiazide diuretic presented as an oral tablet for oral use. It treats hypertension in adult patients.
GNH India supplies Olectan Hct as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

  • Olectan Hct, a combination antihypertensive, is indicated for the management of high blood pressure across several clinical presentations.
  • Hypertension (essential): reduces systolic and diastolic pressure in patients with primary hypertension.
  • Isolated systolic hypertension: lowers elevated systolic values in older adults.
  • Resistant hypertension: provides additional blood‑pressure control when single‑agent therapy is insufficient.

How It Works

  • Olmesartan medoxomil blocks angiotensin II AT1 receptors, preventing vasoconstriction and aldosterone release. Amlodipine inhibits calcium influx into vascular smooth‑muscle cells, causing arterial dilation. Hydrochlorothiazide acts on the distal renal tubule to inhibit NaCl reabsorption, promoting natriuresis and reducing plasma volume. The combined actions produce additive reductions in peripheral resistance and blood volume, resulting in lowered blood pressure.

Side Effects

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Peripheral edema, especially of the ankles
  • Flushing or warmth sensation
  • Increased urinary frequency
  • Mild electrolyte disturbances (e.g., low potassium)

Serious or Rare Side Effects

  • Angioedema or severe swelling of face/lips
  • Marked hypotension leading to fainting
  • Acute kidney injury or worsening renal function
  • Severe electrolyte imbalance (e.g., hyponatremia, hyperkalemia)
  • Pancreatitis (rare)
  • Hepatic dysfunction (rare)

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Monitor blood pressure regularly to assess efficacy.
  • Assess renal function and serum electrolytes, especially potassium and sodium.
  • Evaluate hepatic function in patients with liver disease.
  • Use caution in patients with a history of gout, as thiazides may increase uric acid.
  • Avoid in individuals with severe hypotension or overt heart failure.

Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Olectan Hct may interact with several drug classes; awareness of major and moderate interactions helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Concomitant use with aliskiren in diabetic patients may increase risk of renal impairment.
  • Lithium therapy can lead to lithium toxicity due to reduced clearance.
  • Potassium‑sparing diuretics or supplements may cause dangerous hyperkalemia.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole) can raise amlodipine levels.

Moderate Interactions (Monitor Closely)

  • NSAIDs may blunt antihypertensive effect and affect renal function.
  • ACE inhibitors or other ARBs can increase risk of renal dysfunction and hyperkalemia.
  • Beta‑blockers may produce additive blood‑pressure lowering.
  • Digoxin levels may rise when combined with amlodipine.

Frequently Asked Questions

Olectan Hct is a prescription medication that combines three active agents to lower high blood pressure. It is used in adults with essential hypertension or other forms of elevated blood pressure where a single‑agent therapy does not provide adequate control.

Olmesartan blocks angiotensin II receptors, preventing vasoconstriction. Amlodipine relaxes arterial smooth muscle by inhibiting calcium entry, causing dilation. Hydrochlorothiazide increases urine output by reducing sodium reabsorption in the kidney, lowering blood volume. Together they produce a synergistic reduction in blood pressure.

The specific dose of Olectan Hct is determined by the prescribing clinician based on the patient’s blood‑pressure readings, overall health status, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Olectan Hct is generally not recommended for use during pregnancy because the safety of the combination has not been established. Breastfeeding mothers should consult their healthcare provider, as the drugs may be excreted in milk and could affect the infant.

To place an order, submit an enquiry on the product page at gnhindia.com, providing the required quantity and your institutional credentials. GNH India works with hospitals, pharmacies and procurement teams worldwide, confirming trade or institutional verification before supplying pricing, availability, shipping details and any necessary import documentation.

Compared with single‑component agents, Olectan Hct offers three complementary mechanisms in one tablet, which can improve blood‑pressure control and simplify dosing. It may be preferred over separate pills when patients need both an ARB, a calcium‑channel blocker and a thiazide diuretic, reducing pill burden and improving adherence.

Olectan Hct tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

The medication is taken orally, usually once daily, with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed by a healthcare professional.

Serious risks include severe hypotension, acute kidney injury, significant electrolyte disturbances (especially low potassium or high sodium), and rare cases of angioedema. Patients should report sudden dizziness, swelling of the face or lips, or marked changes in urine output to their doctor promptly.

Olectan Hct should be avoided in patients with known hypersensitivity to any of its components, severe renal or hepatic impairment, uncontrolled heart failure, or those who are pregnant. Individuals with a history of angioedema or severe electrolyte abnormalities should also discuss alternative therapies with their clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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