Product image of Olevia (Omega-3-Acid Ethyl Esters 90) supplied by GNH India

Olevia

Active Ingredient:
Omega-3-Acid Ethyl Esters 90
Origin:
EU

Olevia (Omega-3-Acid Ethyl Esters 90)

Omega-3-acid ethyl esters, the active ingredient in Olevia, is a lipid‑based omega‑3 fatty acid preparation presented as a prescription oil for oral use. It is used to lower markedly elevated triglyceride concentrations in adults with severe hypertriglyceridaemia and related lipid disorders.

GNH India supplies Olevia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ibsa Farmaceutici Italia

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Indications & Clinical Uses

Olevia, an omega‑3 ethyl ester medication, is indicated for disorders of triglyceride metabolism.

  • Severe hypertriglyceridaemia: reduces fasting triglyceride levels to lower the risk of pancreatitis.
  • Familial chylomicronaemia syndrome: lowers triglycerides in patients with this genetic disorder.
  • Mixed dyslipidaemia (adjunct to diet and statins): helps improve overall lipid profile when combined with standard therapy.

How It Works

  • Omega-3-acid ethyl esters are hydrolysed to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). These long‑chain polyunsaturated fatty acids inhibit hepatic very‑low‑density lipoprotein (VLDL) synthesis, enhance beta‑oxidation of fatty acids, and reduce the availability of substrates for triglyceride assembly, resulting in lowered plasma triglyceride concentrations.

Side Effects

Adverse reactions have been reported with Olevia and are categorised by frequency.

Common Side Effects

  • Indigestion: mild gastrointestinal discomfort after dosing.
  • Nausea: occasional feeling of queasiness.
  • Diarrhoea: loose stools in some patients.
  • Fishy aftertaste: detectable taste after ingestion.
  • Headache: transient cranial discomfort.
  • Elevated liver enzymes: mild increases in ALT/AST.

Serious or Rare Side Effects

  • Pancreatitis: inflammation of the pancreas, potentially life‑threatening.
  • Atrial fibrillation: irregular heart rhythm observed in rare cases.
  • Bleeding tendency: increased risk of hemorrhage, especially with anticoagulants.
  • Allergic reactions: rash, angioedema, or anaphylaxis in hypersensitive individuals.

Precautions & Warnings

When prescribing Olevia, clinicians should observe several safety measures.

  • Assess baseline triglyceride levels: obtain fasting measurements before initiation.
  • Monitor liver function: periodic ALT/AST testing is recommended.
  • Consider bleeding risk: evaluate concomitant anticoagulant or antiplatelet therapy.
  • Avoid in patients with fish oil allergy: discontinue if hypersensitivity occurs.
  • Pregnancy and lactation: use only if the therapeutic benefit outweighs potential risks.
  • Store at ambient temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Omega-3-acid ethyl esters may interact with several drug classes.

Major Interactions (Avoid)

  • Anticoagulants (warfarin, DOACs): increased bleeding risk.
  • Antiplatelet agents (aspirin, clopidogrel): additive antithrombotic effect.
  • High‑dose vitamin E: may potentiate anticoagulant activity.

Moderate Interactions (Monitor Closely)

  • Statins: possible elevation of liver enzymes; monitor hepatic function.
  • Fibrates: additive triglyceride‑lowering effect; watch for myopathy.
  • Cyclosporine: may raise omega‑3 levels; monitor renal function and drug concentrations.

Frequently Asked Questions

Olevia contains omega‑3‑acid ethyl esters and is prescribed to lower markedly elevated triglyceride levels in adults with severe hypertriglyceridaemia, including familial chylomicronaemia, and as an adjunct to diet and statin therapy for mixed dyslipidaemia.

After oral administration, the ethyl esters are hydrolysed to EPA and DHA, which inhibit hepatic VLDL synthesis, increase fatty‑acid β‑oxidation, and reduce the substrate pool for triglyceride assembly, thereby decreasing circulating triglyceride concentrations.

The dose is individualized by the prescribing clinician based on the patient’s triglyceride level, body weight, and tolerability. Typical regimens range from 2 g to 4 g per day divided into two doses, but exact dosing must follow the prescriber’s order.

Use during pregnancy or lactation is only recommended when the potential therapeutic benefit justifies any possible risk to the fetus or infant. Clinicians should assess each case individually and discuss the risk‑benefit profile with the patient.

Submit an enquiry on the Olevia product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Olevia provides a concentrated prescription form of omega‑3‑acid ethyl esters, delivering higher EPA/DHA content per gram than most over‑the‑counter fish‑oil supplements. It is approved specifically for triglyceride reduction, whereas many OTC products are marketed for general cardiovascular health without a defined therapeutic indication.

Store Olevia at ambient temperature, preferably below 25 °C, in the original packaging to protect it from moisture and light. Keep the product out of reach of children and do not refrigerate unless otherwise indicated on the label.

Olevia is taken orally, usually with meals to improve absorption. Capsules or liquid oil are swallowed whole; they should not be crushed or chewed unless a pharmacist advises otherwise.

The most serious adverse events include pancreatitis, atrial fibrillation, and significant bleeding, especially when combined with anticoagulant or antiplatelet therapy. Patients should be monitored for signs of abdominal pain, irregular heart rhythm, or unusual bruising/bleeding.

Individuals with a known hypersensitivity to fish or omega‑3 fatty acids, patients with active bleeding disorders, and those on high‑dose anticoagulants without medical supervision should avoid Olevia. Clinicians must assess contraindications before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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