Product image of Olezela (Omeprazole) supplied by GNH India

Olezela

Active Ingredient:
Omeprazole
Origin:
EU

Olezela (Omeprazole)

Omeprazole, the active ingredient in Olezela, is a Proton Pump Inhibitor presented as a 20 mg tablet for oral use. It reduces stomach acid production and is used to treat acid‑related gastrointestinal conditions in adults and children. GNH India supplies Olezela as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

GNH India supplies Olezela as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sia Ingen Pharma

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Indications & Clinical Uses

Omeprazole is a proton‑pump inhibitor that addresses disorders linked to excess gastric acid secretion.

  • Gastro‑esophageal reflux disease (GERD): provides symptomatic relief and promotes healing of esophageal erosion.
  • Peptic ulcer disease: supports ulcer healing and reduces risk of recurrence.
  • Zollinger‑Ellison syndrome: controls hyper‑secretion of gastric acid.
  • Helicobacter pylori eradication regimens (as adjunct): enhances eradication success when combined with antibiotics.
  • NSAID‑associated ulcer prophylaxis: lowers incidence of ulcer formation in at‑risk patients.

How It Works

  • Omeprazole irreversibly binds to the H+/K+‑ATPase enzyme (the gastric proton pump) on the parietal cell surface, inhibiting the final step of acid secretion. This blockade reduces both basal and stimulated gastric acidity, allowing mucosal healing and symptom relief in acid‑related disorders.

Side Effects

Adverse reactions to omeprazole are generally mild and dose‑dependent.

Common Side Effects

  • Headache: mild, transient headache reported in clinical use.
  • Diarrhea: loose stools occurring in a minority of patients.
  • Nausea: occasional feeling of queasiness.
  • Abdominal pain: mild discomfort in the stomach region.
  • Flatulence: increased intestinal gas.
  • Constipation: reduced bowel movements.

Serious or Rare Side Effects

  • Clostridioides difficile infection: severe colitis linked to altered gut flora.
  • Acute interstitial nephritis: sudden kidney inflammation.
  • Hypomagnesemia: low serum magnesium with prolonged therapy.
  • Stevens‑Johnson syndrome: rare severe skin reaction.
  • Fracture risk: possible increased risk of hip, wrist or spine fractures with long‑term use.
  • Liver enzyme elevation: uncommon rise in hepatic transaminases.

Precautions & Warnings

When prescribing omeprazole, clinicians should consider several safety aspects.

  • Assess renal function: adjust use in severe renal impairment.
  • Review concomitant medications: potential for drug‑drug interactions.
  • Monitor long‑term use: evaluate need for continued therapy after several months.
  • Pregnancy and lactation: weigh benefits against potential risks.
  • Elderly patients: use lowest effective dose and monitor for fractures.
  • Store at below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Omeprazole may affect the pharmacokinetics of several co‑administered drugs.

Major Interactions (Avoid)

  • Clopidogrel: reduced antiplatelet effect, may increase cardiovascular risk.
  • Atazanavir: decreased absorption, loss of antiviral efficacy.
  • Dasatinib: lowered plasma concentrations, reduced therapeutic effect.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible increase in INR, monitor coagulation parameters.
  • Phenytoin: altered serum levels, adjust dosing as needed.
  • Methotrexate: increased exposure, especially with high‑dose regimens.

Frequently Asked Questions

Olezela contains omeprazole, a proton‑pump inhibitor that is prescribed for acid‑related gastrointestinal conditions such as gastro‑oesophageal reflux disease, peptic ulcer disease, Zollinger‑Ellison syndrome and as part of Helicobacter pylori eradication regimens.

Omeprazole irreversibly inhibits the gastric H+/K+‑ATPase (proton pump) on parietal cells, blocking the final step of acid secretion. This reduces gastric acidity, allowing damaged mucosa to heal and relieving symptoms caused by excess acid.

The prescribed dose of Olezela is determined by the treating clinician based on the specific indication, patient age, weight and clinical response. Dosage regimens are not standardized in product literature and should follow the prescriber’s instructions.

Omeprazole is classified as pregnancy category B in many regions, indicating no proven risk in animal studies but limited human data. It may be used during pregnancy or lactation only if the potential benefit justifies the potential risk, and under medical supervision.

To order Olezela, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and import documentation.

Olezela (omeprazole) belongs to the proton‑pump inhibitor class, offering more potent and longer‑lasting acid suppression than H2‑receptor antagonists such as ranitidine. Compared with newer PPIs like esomeprazole, omeprazole provides similar efficacy at a lower cost, though individual response may vary.

Store Olezela tablets at temperatures below 25 °C in the original packaging, protecting them from moisture, heat and direct sunlight to maintain potency throughout the shelf‑life.

Olezela tablets are taken orally, usually before a meal. The tablet should be swallowed whole with a glass of water and not crushed or chewed, unless the prescriber provides an alternative administration instruction.

Serious but rare risks include Clostridioides difficile‑associated colitis, acute interstitial nephritis, severe hypersensitivity reactions such as Stevens‑Johnson syndrome, and low magnesium levels with prolonged use. Patients should be monitored for these events, especially during long‑term therapy.

Patients with known hypersensitivity to omeprazole or any component of the tablet should not use Olezela. Caution is also advised for individuals on clopidogrel, atazanavir or other drugs with major interactions, and for those with severe liver impairment where use may be contraindicated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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