Olfen 50 (Diclofenac Sodium)

Diclofenac sodium is an NSAID that reduces inflammation and pain in several musculoskeletal and inflammatory conditions.

• Osteoarthritis: alleviates joint pain and improves mobility.
• Rheumatoid arthritis: decreases joint inflammation and swelling.
• Ankylosing spondylitis: reduces spinal pain and stiffness.
• Acute musculoskeletal sprains and strains: provides short‑term pain relief.
• Post‑operative pain: helps manage pain after minor surgical procedures.

• Diclofenac sodium inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, decreasing the synthesis of prostaglandins that mediate inflammation, pain and fever. By limiting prostaglandin production at sites of tissue injury, it reduces the inflammatory response and associated discomfort.

Adverse reactions to diclofenac sodium can range from mild to severe and may affect multiple organ systems.

Common Side Effects

• Gastrointestinal discomfort: nausea, dyspepsia, abdominal pain.
• Headache: mild to moderate intensity.
• Dizziness or light‑headedness.
• Skin rash or mild itching.
• Elevated liver enzymes.

Serious or Rare Side Effects

• Peptic ulcer disease or gastrointestinal bleeding.
• Severe liver injury or hepatitis.
• Renal impairment or acute kidney injury.
• Cardiovascular events such as myocardial infarction or stroke.
• Severe skin reactions including Stevens‑Johnson syndrome.

When using diclofenac sodium, several safety considerations should be observed:

• Assess renal function: evaluate baseline kidney health before initiating therapy.
• Monitor hepatic function: periodic liver‑function tests are recommended.
• Evaluate cardiovascular risk: use cautiously in patients with known heart disease.
• Avoid concurrent NSAIDs: increase risk of gastrointestinal complications.
• Use the lowest effective dose for the shortest duration needed.
• Store at ambient temperature: keep in the original packaging, protect from moisture and heat.

Diclofenac sodium can interact with a variety of medicines, altering efficacy or safety.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): heightened risk of serious bleeding.
• Selective serotonin reuptake inhibitors (SSRIs): increased gastrointestinal bleeding risk.
• ACE inhibitors or ARBs: may reduce renal perfusion and function.

Moderate Interactions (Monitor Closely)

• Lithium: NSAIDs can raise lithium serum levels.
• Methotrexate: reduced clearance may increase toxicity.
• Corticosteroids: combined use raises ulcer risk.