Product image of Olfen 75 (Diclofenac Sodium, Lidocaine Hydrochloride) supplied by GNH India

Olfen 75

Active Ingredient:
Diclofenac Sodium, Lidocaine Hydrochloride
Origin:
EU

Olfen 75 (Diclofenac Sodium, Lidocaine Hydrochloride)

Diclofenac sodium, the active ingredient in Olfen 75, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as a 75 mg tablet for oral use. It reduces inflammation and pain in musculoskeletal conditions and is often combined with a local anesthetic for enhanced comfort.

GNH India supplies Olfen 75 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Olfen 75 combines diclofenac sodium with lidocaine to target inflammatory pain pathways. It is indicated for:

  • Osteoarthritis: reduces joint pain and improves mobility.
  • Rheumatoid arthritis: alleviates joint inflammation and stiffness.
  • Acute musculoskeletal sprain or strain: provides rapid pain relief and facilitates early movement.

How It Works

  • Diclofenac sodium inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, decreasing prostaglandin synthesis that mediates inflammation, pain and fever. Lidocaine hydrochloride blocks voltage‑gated sodium channels in peripheral nerves, producing a localized anesthetic effect that complements the anti‑inflammatory action of diclofenac.

Side Effects

Olfen 75 may cause a range of adverse reactions.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
  • Headache or dizziness.
  • Mild skin rash or itching.
  • Localized burning at the site of lidocaine action.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Severe skin reactions such as Stevens‑Johnson syndrome.
  • Hepatic dysfunction indicated by elevated enzymes.
  • Renal impairment or sudden loss of kidney function.

Precautions & Warnings

When prescribing Olfen 75, consider the following safety measures:

  • Assess renal function: patients with impaired kidneys may require dose adjustment.
  • Monitor hepatic enzymes: liver disease can increase risk of toxicity.
  • Evaluate cardiovascular risk: NSAIDs may elevate blood pressure or precipitate events.
  • Avoid use in late pregnancy: risk of fetal ductus arteriosus closure.
  • Contraindications: known hypersensitivity to diclofenac, lidocaine or other NSAIDs.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Olfen 75 can interact with several drug classes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened gastrointestinal bleeding risk.
  • Other NSAIDs or COX‑2 inhibitors: additive renal and gastrointestinal toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce renal perfusion.
  • Diuretics: potential for enhanced kidney function decline.
  • Lithium: NSAIDs can raise serum lithium levels.
  • Methotrexate: reduced clearance may increase toxicity.

Frequently Asked Questions

Olfen 75 is a combination of diclofenac sodium and lidocaine hydrochloride indicated for the relief of pain and inflammation associated with osteoarthritis, rheumatoid arthritis and acute musculoskeletal injuries such as sprains or strains.

Diclofenac sodium works by inhibiting cyclo‑oxygenase enzymes (COX‑1 and COX‑2), which reduces the production of prostaglandins that cause inflammation, pain and fever. Lidocaine adds a local anesthetic effect by blocking sodium channels in peripheral nerves.

The appropriate dose of Olfen 75 is determined by the prescribing clinician based on the patient’s condition, age, weight and renal‑function status. The prescriber will set the exact regimen and frequency.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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