Product image of Olfen Depocaps (Diclofenac Sodium) supplied by GNH India

Olfen Depocaps

Active Ingredient:
Diclofenac Sodium
Origin:
EU

Olfen Depocaps (Diclofenac Sodium)

Diclofenac sodium, the active ingredient in Olfen Depocaps, is a non‑steroidal anti‑inflammatory drug presented as a capsule for oral use. It is used to relieve pain and inflammation associated with musculoskeletal disorders and other inflammatory conditions.
GNH India supplies Olfen Depocaps as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Diclofenac sodium is an NSAID that reduces inflammation and pain in several musculoskeletal and inflammatory conditions.

  • Osteoarthritis: alleviates joint pain and improves mobility.
  • Rheumatoid arthritis: reduces joint swelling and pain.
  • Ankylosing spondylitis: eases spinal stiffness and discomfort.
  • Acute musculoskeletal pain: provides rapid relief after injury or strain.
  • Dysmenorrhea: lessens menstrual cramps and associated pain.

How It Works

  • Diclofenac sodium inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, decreasing the synthesis of prostaglandins that mediate inflammation, pain, and fever. By reducing prostaglandin levels at sites of tissue injury, it limits vascular permeability, leukocyte infiltration, and nociceptor sensitisation, resulting in anti‑inflammatory and analgesic effects.

Side Effects

Adverse reactions to diclofenac can range from mild to severe and should be monitored during therapy.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia, or abdominal discomfort.
  • Headache or dizziness.
  • Skin rash or pruritus.
  • Elevated liver enzymes.
  • Mild renal function changes.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or perforation.
  • Severe hepatic injury or hepatitis.
  • Acute renal failure or significant creatinine rise.
  • Cardiovascular events such as myocardial infarction or stroke.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Diclofenac should be used with caution in patients with certain medical conditions and concomitant therapies.

  • Cardiovascular risk: avoid long‑term use in patients with established heart disease.
  • Gastrointestinal safety: assess history of ulcers or bleeding before prescribing.
  • Renal function: monitor kidney parameters in patients with chronic kidney disease.
  • Hepatic monitoring: check liver enzymes periodically, especially in patients with liver disease.
  • Pregnancy and lactation: use only if clearly needed after risk‑benefit assessment.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Diclofenac can interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or aspirin: heightened gastrointestinal toxicity.
  • ACE inhibitors or ARBs: possible reduction in antihypertensive effect and renal impairment.
  • Lithium: elevated lithium levels leading to toxicity.
  • Methotrexate: reduced clearance and potential toxicity.

Moderate Interactions (Monitor Closely)

  • Diuretics: possible decrease in renal perfusion.
  • Corticosteroids: additive risk of gastrointestinal ulceration.
  • SSRIs or SNRIs: modest increase in bleeding tendency.
  • Beta‑blockers: may blunt antihypertensive response.
  • Cyclosporine: increased nephrotoxicity risk.

Frequently Asked Questions

Olfen Depocaps contains diclofenac sodium, an NSAID that is prescribed to relieve pain and reduce inflammation in conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute musculoskeletal injuries and dysmenorrhea. It works by targeting inflammatory pathways to improve comfort and joint function.

Diclofenac sodium blocks the cyclo‑oxygenase enzymes COX‑1 and COX‑2, which are essential for producing prostaglandins. Prostaglandins promote inflammation, pain, and fever, so their reduction leads to decreased swelling, lower pain signals, and reduced fever, providing therapeutic relief in inflammatory disorders.

The specific dose of Olfen Depocaps is determined by the prescribing healthcare professional based on the patient’s condition, severity, age, renal and hepatic function, and other individual factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Diclofenac is generally avoided in the third trimester of pregnancy because of potential fetal cardiovascular effects. Use during earlier pregnancy or while breastfeeding should only occur if the prescriber judges that the benefit outweighs the risk. Women who are pregnant or nursing should discuss alternatives with their doctor.

To request Olfen Depocaps, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Olfen Depocaps (diclofenac) offers potent anti‑inflammatory and analgesic effects comparable to ibuprofen or naproxen, but it may have a higher risk of gastrointestinal and cardiovascular adverse events at equivalent doses. Choice of NSAID depends on the patient’s risk profile, required potency, and physician preference.

Olfen Depocaps should be stored at ambient temperature, preferably below 25 °C. Keep the capsules in their original container, protect them from moisture, heat and direct sunlight, and ensure the packaging remains tightly closed until use.

Olfen Depocaps is taken orally with a full glass of water. It may be taken with or without food, although taking it with food can reduce gastrointestinal discomfort. The exact timing and frequency are set by the prescribing clinician.

Serious risks include gastrointestinal bleeding or perforation, severe liver injury, acute kidney failure, and increased risk of cardiovascular events such as heart attack or stroke. Patients should be monitored for signs of these conditions and seek immediate medical attention if they occur.

Olfen Depocaps is contraindicated in individuals with known hypersensitivity to diclofenac or other NSAIDs, those with active gastrointestinal ulceration or bleeding, severe heart failure, and patients in the third trimester of pregnancy. It should also be avoided in patients with significant renal or hepatic impairment unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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