Product image of Olfen Depocaps (Diclofenac Sodium) supplied by GNH India

Olfen Depocaps

Active Ingredient:
Diclofenac Sodium
Origin:
EU

Olfen Depocaps (Diclofenac Sodium)

Diclofenac sodium, the active ingredient in Olfen Depocaps, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as a topical gel for dermal use. It is used to relieve pain and inflammation associated with musculoskeletal conditions such as osteoarthritis, rheumatoid arthritis and soft‑tissue injuries in adults.

GNH India supplies Olfen Depocaps as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Olfen Depocaps is an NSAID that reduces inflammation and pain in several musculoskeletal disorders.

  • Osteoarthritis: helps relieve joint pain and improves functional movement.
  • Rheumatoid arthritis: decreases joint inflammation and swelling.
  • Acute musculoskeletal injury: alleviates pain and reduces local inflammation.
  • Post‑operative pain: provides short‑term pain control after minor surgical procedures.
  • Ankylosing spondylitis: reduces spinal pain and stiffness.

How It Works

  • Diclofenac sodium inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, reducing the synthesis of prostagOlven prostaglandins that mediate inflammation, pain and fever. This enzymatic blockade lowers inflammatory mediator levels at the site of injury, providing analgesic and anti‑inflammatory effects.

Side Effects

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness: transient light‑headedness.
  • Skin irritation: redness or itching at the application site.
  • Elevated liver enzymes: mild, asymptomatic changes in blood tests.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Severe skin reactions such as Stevens‑Johnson syndrome.
  • Hepatotoxicity: marked elevation of liver enzymes or hepatitis.
  • Renal impairment: acute kidney injury or worsening of chronic kidney disease.
  • Anaphylaxis: sudden onset of hives, swelling and respiratory distress.

Precautions & Warnings

Olfen Depocaps should be used only after evaluating the patient’s medical history and current medication profile.

  • Cardiovascular risk: avoid in patients with uncontrolled hypertension or recent myocardial infarction.
  • Gastrointestinal history: use cautiously in individuals with a history of ulcers or bleeding.
  • Renal function: monitor kidney function in patients with chronic kidney disease.
  • Hepatic function: assess liver enzymes before long‑term use.
  • Pregnancy and lactation: contraindicated in the third trimester and not recommended while breastfeeding.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Diclofenac may interact with several drug classes, requiring careful review before co‑administration.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened gastrointestinal bleeding risk.
  • Other NSAIDs or COX‑2 inhibitors: additive toxicity to the gastrointestinal tract and kidneys.
  • Lithium: diclofenac can raise serum lithium levels, risking toxicity.
  • Methotrexate: may reduce renal clearance and increase methotrexate toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may diminish antihypertensive effect and affect renal function.
  • Diuretics: increased risk of renal impairment.
  • Corticosteroids: higher chance of gastrointestinal ulceration.
  • Beta‑blockers: possible reduction in antihypertensive efficacy.
  • Oral hypoglycemics: may potentiate hypoglycaemic effect.

Frequently Asked Questions

Olfen Depocaps contains diclofenac sodium, an NSAID that is commonly prescribed to manage pain and inflammation associated with conditions such as osteoarthritis, rheumatoid arthritis, acute musculoskeletal injuries and post‑operative discomfort. It works by reducing inflammatory mediators at the site of pain.

Diclofenac sodium blocks the cyclo‑oxygenase enzymes COX‑1 and COX‑2, which are needed for the production of prostaglandins. By lowering prostaglandin levels, the drug diminishes inflammation, pain signals and fever, providing symptomatic relief in affected tissues.

The appropriate dose of Olfen Depocaps is determined by the prescribing clinician based on the patient’s condition, severity of symptoms, age, renal and hepatic function, and any concomitant medications. The prescriber will set the exact regimen.

Diclofenac sodium is generally avoided in the third trimester of pregnancy because of potential risks to the fetus, and it is not recommended while breastfeeding unless the benefit outweighs the risk. Pregnant or nursing patients should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Olfen Depocaps (diclofenac sodium) offers potent anti‑inflammatory and analgesic effects comparable to ibuprofen or naproxen, but it may have a higher risk of gastrointestinal and cardiovascular adverse events. Choice of NSAID depends on individual patient risk factors, required potency and clinician preference.

Olfen Depocaps should be stored at temperatures below 25 °C, in the original packaging, protected from moisture and direct sunlight. This helps maintain the stability and potency of the diclofenac formulation throughout its shelf life.

Olfen Depocaps is taken orally as a capsule. The capsule should be swallowed whole with a glass of water, preferably with food or a meal to reduce potential gastrointestinal irritation.

Serious risks include gastrointestinal bleeding or ulceration, cardiovascular events such as heart attack or stroke, severe skin reactions like Stevens‑Johnson syndrome, liver toxicity, and kidney injury. Patients should be monitored for these events, especially with long‑term use.

Olfen Depocaps is contraindicated in individuals with known hypersensitivity to diclofenac or other NSAIDs, those with active gastrointestinal bleeding, severe heart failure, severe renal or hepatic impairment, and in the third trimester of pregnancy. Clinicians should assess each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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