Product image of Olfen Depotabs (Diclofenac Sodium) supplied by GNH India

Olfen Depotabs

Active Ingredient:
Diclofenac Sodium
Origin:
EU

Olfen Depotabs (Diclofenac Sodium)

Diclofenac Sodium, the active ingredient in Olfen Depotabs, is a nonsteroidal anti-inflammatory drug (NSAID) presented as oral tablets for oral use. It is used to relieve pain and reduce inflammation in conditions such as osteoarthritis, rheumatoid arthritis and acute musculoskeletal pain.
GNH India supplies Olfen Depotabs as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Diclofenac Sodium is an NSAID indicated for several painful and inflammatory conditions.

  • Osteoarthritis: reduces joint pain and improves mobility.
  • Rheumatoid arthritis: alleviates joint inflammation and stiffness.
  • Acute musculoskeletal pain: provides rapid pain relief after injury or strain.
  • Post‑operative pain: helps control pain following surgical procedures.
  • Ankylosing spondylitis: diminishes spinal inflammation and discomfort.

How It Works

  • Diclofenac inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. By lowering prostaglandin synthesis, it reduces inflammation, pain signaling, and fever responses at the site of tissue injury or disease.

Side Effects

Diclofenac may cause a range of adverse reactions.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia, abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Skin rash or mild itching.
  • Elevated liver enzymes detected in laboratory tests.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Severe hepatic injury or jaundice.
  • Renal impairment or acute kidney injury.
  • Cardiovascular events such as myocardial infarction or stroke.
  • Severe hypersensitivity reactions including Stevens‑Johnson syndrome.

Precautions & Warnings

When using Diclofenac, certain precautions should be observed.

  • Cardiovascular risk: avoid in patients with recent myocardial infarction or uncontrolled hypertension.
  • Gastrointestinal safety: use with caution in individuals with a history of ulcers or bleeding.
  • Renal function: monitor kidney parameters in patients with existing renal disease.
  • Hepatic health: assess liver function before and during therapy.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Diclofenac can interact with several drug classes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity.
  • Lithium: elevated lithium serum levels.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible reduction in renal function.
  • Diuretics: may enhance nephrotoxic potential.
  • Methotrexate: increased methotrexate toxicity at high doses.

Frequently Asked Questions

Olfen Depotabs contains diclofenac sodium, an NSAID that is commonly prescribed to manage pain and inflammation associated with osteoarthritis, rheumatoid arthritis, acute musculoskeletal injuries, postoperative discomfort, and ankylosing spondylitis. It helps reduce swelling and improve functional ability in these conditions.

Diclofenac sodium works by inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2, which are essential for converting arachidonic acid into prostaglandins. Lower prostaglandin levels diminish inflammation, pain signaling, and fever, providing symptomatic relief at the site of injury or disease.

The appropriate dose of Olfen Depotabs is determined by the prescribing healthcare professional based on the patient’s specific condition, severity, age, and renal or hepatic function. Dosage instructions are provided on the prescription label and should be followed exactly as directed.

Diclofenac sodium should be used during pregnancy or lactation only if clearly needed and after a risk‑benefit assessment by a qualified clinician. In the first trimester, NSAIDs may affect fetal development, and they can pass into breast milk, potentially impacting the infant.

To place an order, visit the product page for Olfen Depotabs on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Olfen Depotabs (diclofenac) offers potent anti‑inflammatory and analgesic effects comparable to ibuprofen or naproxen, but it may have a higher risk of gastrointestinal and cardiovascular adverse events at equivalent doses. Choice of NSAID depends on individual patient risk factors, therapeutic goals, and clinician preference.

Olfen Depotabs should be stored at temperatures below 25 °C, in a dry place away from direct sunlight. Keep the tablets in the original container to protect them from moisture and humidity, and ensure they are out of reach of children.

Olfen Depotabs is taken orally with a full glass of water. It can be taken with or without food, although taking it with meals may reduce gastrointestinal discomfort. Swallow the tablet whole; do not crush, chew, or split unless specifically instructed by a healthcare professional.

Serious risks include gastrointestinal bleeding or ulceration, severe liver injury, acute kidney failure, and increased cardiovascular events such as heart attack or stroke. Patients should be monitored for signs of these conditions, especially if they have pre‑existing risk factors.

Olfen Depotabs should be avoided in individuals with known hypersensitivity to diclofenac or other NSAIDs, active gastrointestinal ulceration, severe heart failure, uncontrolled hypertension, significant renal or hepatic impairment, and in patients in the third trimester of pregnancy unless deemed essential by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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