Product image of Olfen (Diclofenac Sodium) supplied by GNH India

Olfen

Active Ingredient:
Diclofenac Sodium
Origin:
EU

Olfen (Diclofenac Sodium)

Diclofenac sodium, the active ingredient in Olfen, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as a topical formulation for local use as part of targeted therapy. It reduces pain and inflammation in musculoskeletal conditions and is intended for adult patients requiring targeted relief.

GNH India supplies Olfen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide through regulated channels and quality‑assured logistics. Our global network ensures timely delivery and compliance with local regulatory requirements while maintaining product integrity throughout the supply chain.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

  • Diclofenac sodium is applied topically to manage pain and inflammation in musculoskeletal disorders.
  • Osteoarthritis: reduces joint pain and improves function in affected joints.
  • Rheumatoid arthritis: alleviates inflammatory pain in peripheral joints.
  • Acute musculoskeletal injury: provides localized relief from sprains, strains and bruises.

How It Works

  • Diclofenac sodium inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes reversibly, decreasing the conversion of arachidonic acid to prostaglandins. The reduced prostaglandin synthesis limits inflammation, pain signalling and fever at the site of application, providing localized anti‑inflammatory and analgesic effects without significant systemic exposure when used as a topical preparation. Topical delivery concentrates the drug in the dermal and sub‑dermal tissues, allowing effective enzyme inhibition locally while systemic plasma concentrations remain low, thereby minimizing the risk of systemic adverse events.

Side Effects

Topical diclofenac may cause local and systemic adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Skin irritation: redness, itching or burning at the application site.
  • Dryness: mild peeling or flaking of the skin.
  • Pruritus: localized itching.
  • Mild headache: occasional transient headache.

Serious or Rare Side Effects

  • Severe allergic reaction: angioedema, swelling of face or throat, requiring immediate medical attention.
  • Contact dermatitis: severe rash with blistering.
  • Systemic toxicity: rare hepatic or renal impairment with extensive use.

Precautions & Warnings

  • When using Olfen, consider the following precautions to ensure safe and effective therapy.
  • Avoid use on broken or infected skin: apply only to intact skin.
  • Limit duration: do not exceed the period recommended by the prescriber, typically up to 7 days per site.
  • Concurrent NSAID use: discuss with healthcare professional to avoid additive toxicity.
  • Pregnancy and lactation: consult a physician before use, as safety data are limited.
  • Children: not recommended for patients under 12 years unless advised by a clinician.
  • Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Diclofenac sodium can interact with other medicines, altering efficacy or increasing risk of adverse effects.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Selective COX‑2 inhibitors: additive gastrointestinal toxicity.
  • Systemic corticosteroids: heightened risk of ulceration.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or diuretics: may reduce renal function, monitor kidney parameters.
  • Lithium: diclofenac can raise lithium levels, require serum monitoring.
  • Methotrexate: possible increased toxicity, monitor hepatic function.

Frequently Asked Questions

Olfen is a topical formulation of diclofenac sodium that is used to relieve pain and reduce inflammation associated with musculoskeletal conditions such as osteoarthritis, rheumatoid arthritis and acute injuries like sprains or strains. It is applied directly to the skin over the affected area to provide localized symptom control.

Diclofenac sodium works by reversibly inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are key steps in the production of prostaglandins. By lowering prostaglandin levels, the drug diminishes the inflammatory response and the transmission of pain signals at the site where it is applied.

The appropriate dose of Olfen is determined by the prescribing healthcare professional based on the specific condition, severity of symptoms and patient factors. The prescriber will indicate how much gel or cream to apply, how often, and for how many days.

Safety data for topical diclofenac during pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks with their physician before using Olfen, as the prescriber may recommend alternative therapies.

To order Olfen, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Olfen delivers diclofenac directly to the skin, offering targeted relief with lower systemic exposure compared with oral NSAIDs. This can reduce the risk of gastrointestinal and cardiovascular side effects that are more common with systemic therapy, while still providing effective analgesic and anti‑inflammatory action for localized conditions.

Olfen should be stored below 25 °C in its original container, protected from moisture, heat and direct sunlight. Keep the product out of reach of children and avoid exposing it to extreme temperatures, which could affect its stability and efficacy.

Olfen is applied as a thin layer to clean, dry, intact skin over the painful or inflamed area. The prescriber will advise the frequency—typically two to four times daily—and the duration of treatment, which should not exceed the recommended period without medical review.

Serious risks include severe allergic reactions such as angioedema, systemic toxicity leading to liver or kidney impairment with excessive use, and rare but significant skin reactions like contact dermatitis. Patients should seek immediate medical attention if they experience swelling of the face or throat, widespread rash, or signs of organ dysfunction.

Olfen should be avoided in individuals with known hypersensitivity to diclofenac, other NSAIDs, or any component of the formulation. It is also contraindicated on broken, infected or irritated skin, in children under 12 years unless specifically directed by a clinician, and in patients with severe hepatic or renal impairment without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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