Olfenex Artic (Diclofenac Diethylamine)

Olfenex Artic contains diclofenac diethylamine, an NSAID that reduces inflammation in musculoskeletal disorders.

• Sprains and strains: provides localized pain relief and reduces swelling.
• Osteoarthritis of superficial joints: alleviates joint pain and improves mobility.
• Acute soft‑tissue injuries: diminishes inflammation and facilitates faster recovery.

• Diclofenac diethylamine inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes in peripheral tissues, decreasing prostaglandin synthesis. The reduced prostaglandin levels limit inflammation, pain signalling, and fever responses at the site of application, delivering localized anti‑inflammatory effects without significant systemic exposure.

Adverse reactions to topical diclofenac are generally mild and confined to the application site.

Common Side Effects

• Skin irritation: redness, itching or burning at the site of application.
• Pruritus: mild itching without rash.
• Dryness: localized skin dryness.
• Erythema: mild redness of the skin.

Serious or Rare Side Effects

• Contact dermatitis: severe allergic skin reaction.
• Systemic NSAID effects: rare gastrointestinal bleeding or renal impairment.
• Photosensitivity: heightened skin reaction to sunlight.
• Stevens‑Johnson syndrome: extremely rare but severe skin disorder.

When using Olfenex Artic, consider the following safety measures:

• Avoid application on broken or infected skin: may increase systemic absorption.
• Limit use to the recommended area: excessive surface area can raise systemic exposure.
• Do not use with occlusive dressings: may enhance drug penetration.
• Monitor for allergic reactions: discontinue if severe skin irritation occurs.
• Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Diclofenac diethylamine may interact with several systemic medications, although topical use limits systemic exposure.

Major Interactions (Avoid)

• Anticoagulants: increased risk of bleeding.
• Systemic NSAIDs: additive gastrointestinal toxicity.
• Lithium: heightened lithium serum levels.

Moderate Interactions (Monitor Closely)

• ACE inhibitors: possible reduction in renal function.
• Diuretics: potential for reduced renal perfusion.
• Corticol\u00e9s