Olimel N12 (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Olimel N12 provides amino acid supplementation that supports several clinical situations where protein intake is compromised.

• Malnutrition: Helps restore nitrogen balance and supports tissue repair.
• Post‑operative recovery: Contributes to wound healing and muscle preservation.
• Chronic kidney disease (conservative management): Supplies essential amino acids while limiting nitrogen load.
• Severe burns: Assists in meeting heightened protein requirements for recovery.
• Long‑term parenteral nutrition: Provides a balanced amino acid profile for patients unable to use the gastrointestinal tract.

• The amino acids in Olimel N12 are absorbed through the gastrointestinal tract and enter the systemic circulation, where they serve as substrates for protein synthesis, act as precursors for neurotransmitters and metabolic intermediates, and support cellular energy production. By replenishing depleted amino acid pools, the formulation helps maintain nitrogen balance and supports tissue repair and immune function.

Olimel N12 is generally well tolerated, but adverse reactions may occur.

Common Side Effects

• Nausea: mild to moderate gastrointestinal discomfort.
• Abdominal discomfort: bloating or mild cramping.
• Diarrhea: loose stools, usually transient.
• Metallic taste: temporary alteration in taste perception.
• Headache: mild headache without other neurological signs.

Serious or Rare Side Effects

• Allergic reaction: rash, itching, swelling, or anaphylaxis.
• Hyperammonemia: elevated blood ammonia levels in susceptible individuals.
• Metabolic acidosis: rare disturbance of acid‑base balance.
• Severe electrolyte imbalance: uncommon shifts in potassium or sodium levels.
• Renal function deterioration: rare worsening of kidney parameters in high‑risk patients.

When using Olimel N12, consider the following safety measures.

• Assess renal function: adjust use in patients with impaired kidney clearance.
• Monitor liver enzymes: watch for signs of hepatic stress during prolonged therapy.
• Evaluate nutritional status: ensure supplementation aligns with overall dietary plan.
• Observe for hypersensitivity: discontinue if allergic signs appear.
• Store below 25°C: keep in the original container, protect from moisture and direct sunlight.

Olimel N12 may interact with certain medications and nutrients.

Major Interactions (Avoid)

• High‑dose nitrogen‑based drugs: may increase risk of hyperammonemia.
• Certain anticonvulsants (e.g., valproate): can alter amino acid metabolism.

Moderate Interactions (Monitor Closely)

• Diuretics: may affect electrolyte balance when combined with amino acid load.
• Insulin therapy: amino acids can influence glucose homeostasis.
• Oral protein supplements: risk of excessive protein intake.
• Mineral supplements (e.g., zinc, copper): may compete for absorption.
• Antibiotics that affect gut flora: could modify amino acid absorption.