Olimel N12 (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Olimel N12, an amino acid solution for parenteral nutrition, is used to support protein and nitrogen needs in clinical situations where enteral feeding is not possible.

• Parenteral nutrition for patients unable to receive enteral feeding: provides essential amino acids to meet nutritional requirements.
• Surgical, trauma, or critically ill patients: supports protein synthesis and nitrogen balance during increased metabolic demand.
• Patients with severe malnutrition or catabolic states: helps restore lean body mass and improve clinical outcomes.

• Olimel N12 delivers a balanced mixture of essential and non‑essential amino acids directly into the bloodstream. The amino acids serve as substrates for protein synthesis, replenish nitrogen stores, and support cellular metabolism. By bypassing the gastrointestinal tract, the solution ensures rapid availability of these building blocks, facilitating tissue repair, immune function, and maintenance of lean body mass in patients receiving parenteral nutrition.

Adverse reactions to Olimel N12 may vary in frequency and severity.

Common Side Effects

• Hyperglycemia: elevated blood glucose levels, especially in diabetic patients.
• Electrolyte disturbances: changes in serum potassium, calcium, or phosphate.
• Infusion site reactions: erythema, pain, or phlebitis at the catheter site.
• Nausea or vomiting: mild gastrointestinal discomfort.

Serious or Rare Side Effects

• Metabolic acidosis: significant acid‑base imbalance requiring medical intervention.
• Allergic reactions: anaphylaxis, urticaria, or severe skin rash.
• Hyperosmolarity: fluid overload or pulmonary edema in susceptible patients.

When prescribing or handling Olimel N12, consider the following precautions to ensure patient safety.

• Renal impairment: monitor renal function and adjust amino acid load as needed.
• Hepatic dysfunction: assess liver enzymes and avoid excess nitrogen load.
• Fluid balance: watch for signs of fluid overload, especially in cardiac patients.
• Electrolyte monitoring: regularly check serum electrolytes during therapy.
• Hyperglycemia risk: closely monitor blood glucose in diabetic or pre‑diabetic patients.
• Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Olimel N12 may interact with certain medications or clinical conditions.

Major Interactions (Avoid)

• High‑dose insulin therapy: may exacerbate hypoglycemia when combined with amino acid‑induced glucose shifts.
• Loop diuretics: can worsen electrolyte disturbances when amino acid solution is administered concurrently.

Moderate Interactions (Monitor Closely)

• Corticosteroids: may increase protein catabolism, requiring adjustment of amino acid dosing.
• Parenteral lipid emulsions: co‑administration can affect osmolarity and fluid balance.
• Anticoagulants (e.g., heparin): monitor coagulation parameters as amino acids may influence platelet function.