Olimel N12 (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Olimel N12 provides amino acid supplementation for conditions where protein turnover is increased.

• Post‑operative recovery: helps maintain nitrogen balance during wound healing.
• Chronic kidney disease: supports dietary protein needs when intake is restricted.
• Severe malnutrition: contributes to rebuilding lean body mass.
• Metabolic disorders: assists in correcting specific amino‑acid deficiencies.
• Critical illness (ICU): aids in meeting heightened nutritional requirements.

• Olimel N12 supplies a balanced profile of essential and non‑essential amino acids that are directly incorporated into cellular protein synthesis pathways. By providing substrates for the mTOR signaling cascade, the formulation promotes anabolic processes, supports nitrogen balance, and helps restore tissue integrity in states of catabolism.

Amino acid mixtures are generally well tolerated, but adverse reactions can occur.

Common Side Effects

• Nausea: mild gastrointestinal upset reported by some patients.
• Abdominal discomfort: bloating or mild cramping.
• Diarrhea: loose stools, usually transient.
• Headache: occasional mild headache.
• Metallic taste: perception of a metallic flavor in the mouth.

Serious or Rare Side Effects

• Allergic reaction: rash, itching, or swelling indicating hypersensitivity.
• Hyperammonemia: elevated blood ammonia levels in susceptible individuals.
• Metabolic acidosis: rare disturbance of acid‑base balance.
• Severe gastrointestinal intolerance: persistent vomiting or severe diarrhea.
• Anaphylaxis: life‑threatening systemic reaction requiring immediate medical attention.

Before initiating therapy with Olimel N12, consider the following safety measures.

• Renal impairment: adjust dose or monitor nitrogen waste products.
• Hepatic dysfunction: watch for signs of hyperammonemia.
• Pregnancy & lactation: use only if clearly needed; discuss risks with a physician.
• Pediatric use: limit to children under specialist supervision.
• Concomitant high‑protein diets: avoid excessive total protein intake.
• Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Amino acid formulations can influence the absorption or metabolism of certain medicines.

Major Interactions (Avoid)

• Levodopa: may compete for transport across the intestinal wall, reducing efficacy.
• Thyroid hormone replacement (levothyroxine): can impair absorption if taken simultaneously.

Moderate Interactions (Monitor Closely)

• Anticonvulsants (e.g., valproate): may alter plasma amino‑acid levels.
• Antibiotics (tetracyclines, quinolones): chelation risk reducing antibiotic bioavailability.
• Iron supplements: decreased iron absorption when co‑administered.