Olimel N12 (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Olimel N12 provides amino acid supplementation for conditions where protein turnover is increased or intake is insufficient.

• Post‑operative recovery: helps maintain nitrogen balance and supports tissue repair.
• Severe burns: contributes to wound healing and reduces catabolism.
• Chronic renal failure on dialysis: supplies essential amino acids lost during treatment.
• Malnutrition in critical illness: assists in meeting metabolic demands.
• Short‑term total parenteral nutrition (TPN): forms part of the amino acid component of TPN regimens.

• The amino acids in Olimel N12 are directly incorporated into the body's protein synthesis pathways. They serve as substrates for enzymatic reactions that generate new proteins, support nitrogen balance, and act as precursors for neurotransmitters and metabolic intermediates, thereby facilitating tissue repair and metabolic homeostasis.

Adverse reactions to amino acid mixtures are generally infrequent but can occur.

Common Side Effects

• Mild nausea or vomiting
• Transient flushing or warmth at the infusion site
• Slight increase in serum urea nitrogen
• Headache
• Mild electrolyte disturbances (e.g., potassium shifts)

Serious or Rare Side Effects

• Severe hypersensitivity or anaphylaxis
• Hyperosmolar hyperglycaemic syndrome
• Metabolic acidosis
• Hyperuricaemia
• Renal tubular dysfunction
• Thrombophlebitis at the infusion site

When using Olimel N12, consider the following safety measures:

• Assess renal function: adjust infusion rate in patients with impaired clearance.
• Monitor electrolytes: watch for shifts in potassium, calcium and magnesium.
• Evaluate hepatic status: amino acid metabolism may be altered in liver disease.
• Observe for signs of infection: maintain aseptic technique during preparation and administration.
• Review concomitant nutrition: avoid excessive total nitrogen intake.
• Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Amino acid solutions can interact with certain medications and clinical conditions.

Major Interactions (Avoid)

• High‑dose vitamin C infusions: may increase oxalate load and precipitate renal stones.
• Certain anticonvulsants (e.g., phenobarbital): can increase amino‑acid catabolism.

Moderate Interactions (Monitor Closely)

• Loop diuretics: may exacerbate electrolyte shifts.
• Insulin therapy: amino acids stimulate insulin release, affecting glucose control.
• Renal replacement therapies: can remove amino acids, altering intended dosing.
• Acid‑base altering agents: may modify the solution’s pH and affect tolerance.