Product image of Olimel N12e (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin) supplied by GNH India

Olimel N12e

Active Ingredient:
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin
Origin:
EU

Olimel N12e (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serine, the active ingredient in Olimel N12e, is a mixture of essential amino acids presented as a sterile solution for injection for intravenous use. It provides nutritional support for patients who cannot meet protein requirements by oral intake, such as those on parenteral nutrition.
GNH India supplies Olimel N12e as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Baxter D.O.O.

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Indications & Clinical Uses

  • Olimel N12e supplies essential amino acids for patients receiving parenteral nutrition.
  • Parenteral nutrition: supports protein synthesis and metabolic needs in patients unable to eat orally.
  • Critical care: provides amino acid supplementation for critically ill patients.
  • Post‑operative recovery: aids tissue repair in patients requiring intravenous nutritional support.

How It Works

  • When administered intravenously, the amino acids in Olimel N12e are rapidly distributed into the plasma and taken up by cells for protein synthesis, nitrogen balance restoration, and energy metabolism. The mixture replenishes essential amino acid pools, supporting tissue repair, immune function, and metabolic pathways that depend on these substrates.

Side Effects

Adverse reactions may occur with any intravenous amino acid solution.

Common Side Effects

  • Infusion site reactions: erythema, pain, or swelling at the catheter site.
  • Mild electrolyte disturbances: transient hypernatremia or hypokalemia.
  • Metabolic alkalosis: due to bicarbonate load in the solution.
  • Hyperglycemia: especially in patients receiving concomitant dextrose.
  • Nausea or mild gastrointestinal discomfort.

Serious or Rare Side Effects

  • Anaphylactic or severe hypersensitivity reactions.
  • Severe hyperammonemia in patients with hepatic impairment.
  • Acute renal dysfunction or worsening of pre‑existing kidney disease.
  • Catheter‑related sepsis secondary to contaminated infusion.

Precautions & Warnings

  • Clinicians should observe several safety measures before and during administration.
  • Assess renal function: evaluate creatinine clearance prior to initiation.
  • Monitor electrolytes: check serum sodium, potassium, and bicarbonate regularly.
  • Check for hypersensitivity: review patient history of amino acid or protein allergies.
  • Use aseptic technique: ensure sterile handling of the infusion set and solution.
  • Adjust for hepatic impairment: consider reduced nitrogen load in patients with liver disease.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Potential drug interactions should be reviewed to avoid complications.

Major Interactions (Avoid)

  • Concurrent high‑dose potassium supplements: may precipitate hyperkalemia.
  • Co‑administration with other parenteral nutrition solutions containing overlapping amino acids: risk of excess nitrogen load.
  • Renal replacement therapy (dialysis): alters amino acid clearance and may require dose adjustment.

Moderate Interactions (Monitor Closely)

  • Loop or thiazide diuretics: monitor electrolyte balance closely.
  • Insulin therapy: watch for fluctuations in blood glucose levels.
  • Corticosteroids: may increase protein catabolism, requiring closer nutritional assessment.
  • Anticoagulants used in catheter lines: observe for bleeding at infusion sites.

Frequently Asked Questions

Olimel N12e is an intravenous solution that provides a balanced blend of essential amino acids. It is used to support patients who require parenteral nutrition, such as those who cannot eat or absorb nutrients through the gastrointestinal tract, including critically ill, postoperative, or long‑term hospitalized individuals.

The amino acids in Olimel N12e are directly delivered into the bloodstream, where they become available for protein synthesis, nitrogen balance, and energy metabolism. By replenishing essential amino acid pools, the solution helps maintain lean body mass, supports wound healing, and sustains immune function during periods of nutritional deprivation.

The dose of Olimel N12e is individualized by the prescribing clinician based on the patient’s weight, metabolic needs, renal and hepatic function, and overall nutritional plan. Healthcare professionals calculate the appropriate volume and rate of infusion to meet the patient’s specific amino acid requirements.

Safety data for Olimel N12e in pregnancy and lactation are limited. The product should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To order Olimel N12e, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling if needed), and necessary import documentation.

Olimel N12e offers a comprehensive profile of ten essential amino acids in a single sterile solution, matching or exceeding the amino acid composition of many standard parenteral nutrition formulations. Its EU‑origin manufacturing and GDP compliance provide assurance of quality, while the specific blend may differ from competitor products that use alternative ratios or additional non‑essential amino acids.

Olimel N12e must be stored at 2‑8 °C, protected from light, and kept in its original container. Do not freeze or shake the solution. Before use, inspect the vial for particulate matter or discoloration and allow it to reach room temperature if required for infusion.

The product is administered intravenously as a sterile solution. It is typically infused through a dedicated catheter or central line, with the rate and volume determined by the prescribing clinician based on the patient’s nutritional prescription and clinical status.

Serious risks include severe hypersensitivity reactions such as anaphylaxis, hyperammonemia in patients with liver dysfunction, and acute renal impairment in susceptible individuals. Monitoring for signs of allergic reaction, metabolic disturbances, and renal function is essential during therapy.

Olimel N12e should be avoided in patients with known hypersensitivity to any of its amino acid components, those with uncontrolled severe electrolyte imbalances, or individuals with acute renal or hepatic failure where the risk of nitrogen overload outweighs benefit. Clinical judgment is required for each case.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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