Product image of Olimel N12e (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin) supplied by GNH India

Olimel N12e

Active Ingredient:
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin
Origin:
EU

Olimel N12e (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serine, the active ingredients in Olimel N12e, is an amino acid solution presented as a solution for injection for intravenous use. It provides essential and non‑essential amino acids to support protein synthesis and nitrogen balance in patients requiring parenteral nutrition.

GNH India supplies Olimel N12e as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Baxter Healthcare Srl

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Indications & Clinical Uses

Olimel N12e, an amino acid solution for parenteral nutrition, is used to support protein synthesis and nitrogen balance in several clinical situations.

  • Parenteral nutrition for patients unable to receive enteral feeding: provides essential amino acids to meet nutritional needs.
  • Support of protein synthesis in catabolic states: helps maintain lean body mass during severe illness or trauma.
  • Pre‑ and post‑operative nutritional support: supplies amino acids to aid recovery after surgery.

How It Works

  • The solution delivers a balanced mixture of essential and non‑essential amino acids directly into the bloodstream, bypassing gastrointestinal absorption. Cells take up these amino acids and incorporate them into newly synthesized proteins, thereby supporting tissue repair, maintaining nitrogen balance, and counteracting catabolic loss during critical illness or after surgery.

Side Effects

Adverse reactions may occur with intravenous amino acid solutions.

Common Side Effects

  • Phlebitis at infusion site: redness, pain, or swelling.
  • Mild hyperglycemia: transient elevation of blood glucose.
  • Electrolyte disturbances (e.g., hypokalemia): changes in serum potassium.
  • Nausea: occasional feeling of queasiness.
  • Vomiting: occasional episodes during infusion.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe allergic response requiring immediate treatment.
  • Severe metabolic acidosis: significant drop in blood pH.
  • Hyperammonemia: elevated ammonia levels, especially in hepatic impairment.
  • Renal dysfunction: impaired kidney function in susceptible patients.

Precautions & Warnings

When using Olimel N12e, clinicians should consider several safety measures.

  • Assess renal function: adjust dosage in patients with impaired renal clearance.
  • Monitor electrolytes: amino acid solutions can affect serum potassium, phosphate, and magnesium levels.
  • Check liver function: patients with hepatic dysfunction may develop hyperammonemia.
  • Observe for infusion reactions: monitor site for redness, swelling, or pain.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Olimel N12e may interact with other therapies administered concurrently.

Major Interactions (Avoid)

  • Concurrent high‑dose glucose solutions: may cause hyperglycemia.
  • Other parenteral nutrition components (lipid emulsions) mixed in the same line: risk of precipitation.

Moderate Interactions (Monitor Closely)

  • Renal toxic drugs (e.g., aminoglycosides): increased risk of nephrotoxicity.
  • Diuretics: may exacerbate electrolyte shifts.
  • Insulin therapy: may require dose adjustment due to glucose load from the solution.

Frequently Asked Questions

Olimel N12e is an intravenous amino acid solution used as part of parenteral nutrition. It supplies essential and non‑essential amino acids to patients who cannot receive enteral feeding, supports protein synthesis during catabolic states, and provides nutritional support before and after surgery.

The mixture delivers a balanced profile of essential and non‑essential amino acids directly into the bloodstream. Cells absorb these amino acids and incorporate them into proteins, helping to maintain nitrogen balance, promote tissue repair, and counteract muscle loss during illness or after operative procedures.

The dose of Olimel N12e is individualized. A qualified prescriber determines the volume and rate of infusion based on the patient’s weight, metabolic needs, renal and hepatic function, and overall clinical condition. No fixed regimen is provided in the product information.

Safety data for Olimel N12e in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by the treating physician in consultation with the patient.

To order Olimel N12e, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Olimel N12e offers a comprehensive blend of ten amino acids in a ready‑to‑use sterile solution. Compared with other products such as TrophAmine or Aminoplas, it provides a similar amino acid profile but may differ in concentration, osmolarity, and packaging. Choice of product often depends on institutional protocols, compatibility with other nutrition components, and logistical considerations.

Olimel N12e must be stored refrigerated at 2‑8 °C. Keep the vials in the original packaging, protect them from light, and avoid freezing or shaking. If the product reaches room temperature, it should be used promptly and not be re‑refrigerated.

The solution is administered intravenously, typically via a peripheral or central venous catheter. It is infused as a continuous or intermittent infusion, with the rate adjusted according to the patient’s metabolic requirements and clinical response. Administration should be performed by trained healthcare personnel under aseptic conditions.

Serious risks include anaphylactic reactions, severe metabolic acidosis, hyperammonemia (especially in patients with liver dysfunction), and renal impairment. Monitoring of vital signs, blood chemistry, and organ function is essential during therapy to detect and manage these events promptly.

Patients with known hypersensitivity to any of the amino acids in the formulation should avoid Olimel N12e. Caution is also advised for individuals with severe hepatic failure, uncontrolled hyperglycemia, or those receiving incompatible intravenous solutions in the same line without proper flushing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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