Olimel N12e (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Olimel N12e is used in parenteral nutrition to supply essential amino acids for patients who cannot receive enteral feeding.

• Parenteral nutrition: supports protein synthesis and nitrogen balance in patients receiving total parenteral nutrition.
• Amino acid supplementation: restores essential amino acid levels in critically ill or postoperative patients.
• Support of patients unable to receive enteral nutrition: provides necessary nutrients when gastrointestinal tract use is contraindicated.

• Olimel N12e delivers a balanced mixture of essential and non‑essential amino acids directly into the bloodstream. The amino acids serve as substrates for protein synthesis, replenish nitrogen stores, and support metabolic pathways such as gluconeogenesis and neurotransmitter production. By bypassing the gastrointestinal tract, the solution ensures rapid availability of these building blocks for tissue repair, immune function and energy metabolism in patients dependent on intravenous nutrition.

Adverse reactions may occur with any intravenous amino acid solution. Monitoring during infusion is recommended.

Common Side Effects

• Hyperglycemia: elevated blood glucose levels during infusion.
• Electrolyte imbalance: changes in potassium, sodium or calcium concentrations.
• Phlebitis: inflammation of the vein at the infusion site.
• Mild nausea or vomiting.
• Transient headache.

Serious or Rare Side Effects

• Anaphylactic reaction: severe allergic response requiring immediate medical attention.
• Metabolic acidosis: significant drop in blood pH.
• Severe hypotension: sudden low blood pressure.
• Renal dysfunction: worsening kidney function in susceptible patients.
• Thrombosis: clot formation at the catheter site.

Careful assessment and monitoring are required when administering Olimel N12e.

• Monitor blood glucose: patients may develop hyperglycemia during infusion.
• Assess renal function: adjust dosing in patients with impaired kidney clearance.
• Check electrolyte levels: risk of imbalances, especially potassium and calcium.
• Observe infusion site: watch for phlebitis, infiltration or thrombosis.
• Use aseptic technique: prevent contamination of the intravenous line.
• Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Olimel N12e may interact with other medications or solutions administered concurrently.

Major Interactions (Avoid)

• Concurrent high‑dose insulin therapy: may cause severe hypoglycemia.
• Incompatible calcium‑containing solutions: can precipitate and obstruct lines.

Moderate Interactions (Monitor Closely)

• Loop diuretics: may increase electrolyte loss, requiring closer monitoring.
• Corticosteroids: may enhance protein catabolism, affecting amino acid balance.
• Renal replacement therapy: may alter amino acid clearance and necessitate dose adjustment.