Olimel Peri N4e (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Olimel Peri N4e provides amino acid supplementation for conditions where protein turnover is increased.

• Post‑operative recovery: helps maintain nitrogen balance during tissue repair.
• Chronic kidney disease: supports nutritional status when dietary protein is restricted.
• Severe burns or trauma: aids in rebuilding muscle protein loss.
• Malnutrition in elderly patients: contributes to overall protein intake.
• Metabolic disorders affecting amino acid utilization: assists in correcting deficiencies.

• The formulation supplies a balanced profile of essential and non‑essential amino acids that are directly incorporated into protein synthesis pathways. By increasing plasma concentrations of these amino acids, the product promotes nitrogen retention, supports cellular repair mechanisms, and facilitates the synthesis of enzymes and structural proteins required for tissue regeneration.

Amino acid mixtures are generally well tolerated, but adverse reactions can occur.

Common Side Effects

• Nausea: mild gastrointestinal discomfort.
• Diarrhea: loose stools, usually transient.
• Abdominal bloating: feeling of fullness or gas.
• Metallic taste: temporary alteration in taste perception.
• Headache: mild to moderate intensity.
• Skin redness at oral mucosa: mild irritation.

Serious or Rare Side Effects

• Allergic reaction: rash, itching, swelling, or anaphylaxis.
• Hyperammonemia: elevated blood ammonia levels, especially in severe liver disease.
• Metabolic acidosis: rare disturbance of acid‑base balance.
• Severe electrolyte imbalance: uncommon but possible with high‑dose regimens.
• Renal function deterioration: in patients with pre‑existing kidney impairment.
• Unexplained fever: persistent temperature rise without infection.

Before prescribing Olimel Peri N4e, consider patient‑specific factors and monitor relevant clinical parameters.

• Renal impairment: adjust dosage and monitor kidney function tests.
• Hepatic disease: watch for signs of hyperammonemia.
• Pregnancy and lactation: evaluate risk‑benefit ratio; use only if clearly needed.
• Concomitant nutrition therapy: coordinate with dietitian to avoid excess protein.
• Pediatric use: limit to specialist supervision and appropriate dosing.
• Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Amino acid supplements can influence the pharmacokinetics of certain medicines.

Major Interactions (Avoid)

• Levodopa: competition for transport may reduce central availability.
• Anticonvulsants (e.g., valproate): may alter plasma amino acid levels.

Moderate Interactions (Monitor Closely)

• Thyroid hormones: high amino acid load can affect absorption.
• Iron supplements: concurrent intake may decrease iron absorption.
• Antibiotics (tetracyclines, quinolones): calcium in the formulation can bind and reduce efficacy.
• Diuretics: risk of electrolyte shifts when combined with high amino acid intake.
• Warfarin: monitor INR if large amounts of protein are introduced.