Product image of Olimel Perifer N4e (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin) supplied by GNH India

Olimel Perifer N4e

Active Ingredient:
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin
Origin:
EU

Olimel Perifer N4e (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin, the active ingredient in Olimel Perifer N4e, is a mixture of essential and non‑essential amino acids presented as a nutritional supplement for oral use. It supports metabolic functions and protein synthesis in patients requiring specialized nutritional support.

GNH India supplies Olimel Perifer N4e as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

Manufacturer / TM Owner

Baxter Oy

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Indications & Clinical Uses

Olimel Perifer N4e provides amino acids that act on protein metabolism pathways and is used in clinical nutrition contexts.

  • Post‑operative recovery: helps maintain nitrogen balance and supports tissue repair.
  • Chronic kidney disease management: supplies essential amino acids while limiting nitrogen load.
  • Severe malnutrition: contributes to rebuilding lean body mass and improving nutritional status.

How It Works

  • The formulation delivers a balanced profile of essential and non‑essential amino acids that are directly incorporated into protein synthesis pathways. By supplying substrates for the mTOR signaling cascade, it promotes cellular growth and repair while supporting gluconeogenesis and nitrogen balance in catabolic states.

Side Effects

Amino‑acid mixtures are generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea: mild gastrointestinal discomfort reported in some patients.
  • Diarrhea: loose stools may appear during initial administration.
  • Abdominal cramping: transient stomach pain.
  • Metallic taste: occasional alteration in taste perception.
  • Headache: mild headache reported.
  • Skin redness at oral mucosa: mild irritation.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, swelling, or anaphylaxis.
  • Hyperammonemia: elevated blood ammonia in patients with severe liver dysfunction.
  • Metabolic acidosis: rare disturbance of acid‑base balance.
  • Severe electrolyte imbalance: uncommon but possible with prolonged high‑dose use.

Precautions & Warnings

When prescribing Olimel Perifer N4e, consider patient‑specific factors and monitor for potential issues.

  • Renal impairment: adjust dosage and monitor nitrogen waste.
  • Hepatic dysfunction: watch for signs of hyperammonemia.
  • Pregnancy and lactation: use only if clearly needed; benefits must outweigh risks.
  • Pediatric use: limit to specialist‑guided protocols.
  • Concomitant nutrition therapy: avoid excessive total protein intake.
  • Store below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Amino‑acid supplements can interact with certain medications and nutrients.

Major Interactions (Avoid)

  • Levodopa: may reduce absorption of the drug, diminishing its efficacy.
  • Anticonvulsants (e.g., valproate): can increase ammonia production, raising risk of hyperammonemia.

Moderate Interactions (Monitor Closely)

  • Iron supplements: may compete for intestinal absorption, lowering iron uptake.
  • Thyroid hormone replacement: high amino‑acid load could affect hormone binding.
  • Diuretics: may exacerbate electrolyte shifts when combined with high protein loads.

Frequently Asked Questions

Olimel Perifer N4e is a medical‑grade amino‑acid mixture used in clinical nutrition to support protein synthesis, maintain nitrogen balance, and aid recovery in patients after surgery, those with chronic kidney disease, or individuals suffering from severe malnutrition.

The blend supplies both essential and non‑essential amino acids that act as direct substrates for the body’s protein‑building pathways. By providing these building blocks, it stimulates the mTOR signaling cascade, promotes cellular repair, and helps regulate glucose and nitrogen metabolism during catabolic stress.

The prescribed dose of Olimel Perifer N4e is determined by the treating clinician based on the patient’s nutritional status, underlying condition, and overall protein requirements. Dosage is individualized and should follow the healthcare professional’s recommendation.

Use in pregnancy or lactation is permitted only when clearly indicated and when the expected benefit to the mother or infant outweighs potential risks. Clinicians should evaluate each case carefully and monitor both mother and child for any adverse effects.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Olimel Perifer N4e offers a comprehensive profile of ten amino acids, providing a balanced mixture that may be more suitable for patients needing both essential and non‑essential amino acids. Compared with single‑amino‑acid products, it can simplify formulation and reduce the need for multiple supplements.

Store the product below 25 °C in its original packaging, protecting it from moisture and direct sunlight. Ensure the container is tightly sealed to maintain stability and prevent contamination.

The product is supplied as an oral formulation that can be mixed with water or a suitable nutritional beverage. Administration should follow the prescribing clinician’s instructions regarding volume, timing and any accompanying dietary recommendations.

Serious risks, though rare, include allergic reactions such as rash, itching, swelling or anaphylaxis, as well as metabolic complications like hyperammonemia and severe electrolyte disturbances, particularly in patients with liver or kidney impairment.

Patients with known hypersensitivity to any of the listed amino acids, those with uncontrolled severe liver disease, or individuals for whom a high protein load is contraindicated should avoid using this product unless a specialist determines it is safe.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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