Olimel Periferico N4e (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Olimel Periferico N4e provides an amino‑acid solution for patients with increased metabolic demand or protein loss. It is used in:

• Post‑operative recovery: helps maintain nitrogen balance and supports tissue repair.
• Severe trauma or burns: supplies essential amino acids needed for wound healing.
• Chronic kidney disease on dialysis : assists in preventing malnutrition and muscle wasting.
• Long‑term parenteral nutrition: provides a balanced amino‑acid profile for patients who cannot receive enteral feeding.
• Critical‑care intensive care unit (ICU) patients: contributes to overall nutritional support.
• Metabolic disorders : aids in correcting specific amino‑acid deficiencies.

• The formulation delivers a balanced mixture of essential and non‑essential amino acids directly into the bloodstream, bypassing gastrointestinal absorption. These amino acids serve as substrates for protein synthesis, support gluconeogenesis, and replenish nitrogen stores, thereby helping to restore metabolic balance in catabolic states and supporting tissue repair and immune function.

Amino‑acid solutions may cause infusion‑related reactions, which vary in frequency and severity.

Common Side Effects

• Mild nausea: transient discomfort during or after infusion.
• Transient headache: brief headache that resolves without intervention.
• Low‑grade fever: mild temperature rise during treatment.
• Local irritation: redness or warmth at the infusion site.
• Electrolyte shift: minor changes in serum electrolytes.
• Hyperglycaemia: temporary rise in blood glucose levels.

Serious or Rare Side Effects

• Anaphylactic reaction: sudden, severe allergic response requiring emergency care.
• Severe hypotension: marked drop in blood pressure during infusion.
• Metabolic acidosis: significant disturbance in acid‑base balance.
• Thrombophlebitis: inflammation of a vein with clot formation.
• Acute renal impairment: sudden decline in kidney function.
• Seizure activity: rare neurologic event linked to metabolic imbalance.

When using Olimel Periferico N4e, clinicians should consider several safety measures.

• Assess renal function: evaluate baseline creatinine and glomerular filtration rate.
• Monitor electrolytes: check serum sodium, potassium, and calcium regularly.
• Observe infusion site: watch for signs of phlebitis or infiltration.
• Adjust for liver disease: reduce dose if hepatic impairment is present.
• Use aseptic technique: maintain sterility throughout preparation and administration.
• Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Olimel Periferico N4e may interact with other agents administered intravenously.

Major Interactions (Avoid)

• Concurrent high‑dose potassium chloride: may cause dangerous hyper‑kalemia.
• Acidic intravenous solutions: can precipitate amino acids, reducing efficacy.

Moderate Interactions (Monitor Closely)

• Diuretics: may amplify electrolyte disturbances.
• Insulin therapy: heightened risk of hypoglycaemia when combined with hyperglycaemic effect of the amino‑acid mix.
• Anticoagulants: potential alteration of coagulation parameters.
• Parenteral lipid emulsions: may affect the stability of the amino‑acid solution.
• Other parenteral nutrition components: require compatibility checks.