Product image of Olimel (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin) supplied by GNH India

Olimel

Active Ingredient:
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin
Origin:
EU

Olimel (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serine, the active ingredient in Olimel, is a nutritional supplement presented as an intravenous solution for intravenous use. It supplies a balanced mixture of essential and non‑essential amino acids to support protein synthesis, maintain nitrogen balance, and provide caloric support in patients who cannot receive enteral feeding.

GNH India supplies Olimel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics and research institutions worldwide.

Manufacturer / TM Owner

Baxter Deutschland Gmbh

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Indications & Clinical Uses

Olimel is used in parenteral nutrition to provide amino acids for patients who cannot receive enteral feeding.

  • Inability to tolerate enteral feeding: supplies essential amino acids to maintain protein synthesis and nitrogen balance.
  • Critical illness: supports metabolic demands and prevents catabolism in intensive‑care patients.
  • Postoperative recovery: aids tissue repair and wound healing by providing building blocks for new protein.

How It Works

  • Olimel delivers a balanced mixture of essential and non‑essential amino acids directly into the bloodstream. The amino acids are taken up by cells, where they stimulate the mTOR signaling pathway and other translational mechanisms, promoting protein synthesis, supporting nitrogen balance, and providing substrates for gluconeogenesis and energy production in patients unable to ingest nutrients orally.

Side Effects

Adverse reactions may occur with intravenous amino‑acid solutions. Monitoring during infusion is recommended.

Common Side Effects

  • Infusion site phlebitis or erythema.
  • Mild hypernatremia or electrolyte shift.
  • Transient fever or chills.
  • Nausea or mild gastrointestinal discomfort.
  • Headache.
  • Mild metabolic alkalosis.

Serious or Rare Side Effects

  • Anaphylactic or severe allergic reaction.
  • Severe electrolyte imbalance (hyperkalemia, hypocalcemia).
  • Acute renal dysfunction or oliguria.
  • Hepatic dysfunction with elevated transaminases.
  • Severe hyperammonemia.
  • Sepsis related to contaminated infusion.

Precautions & Warnings

When using Olimel, consider the following safety measures.

  • Assess renal function: monitor creatinine and adjust infusion rate as needed.
  • Monitor electrolytes: watch serum sodium, potassium, calcium, and phosphate levels.
  • Check for allergies: ensure no known hypersensitivity to any amino acid component.
  • Use aseptic technique: prepare and administer under sterile conditions to prevent contamination.
  • Avoid in patients with inborn errors of amino‑acid metabolism: contraindicated in such metabolic disorders.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Potential drug interactions should be evaluated before initiating therapy.

Major Interactions (Avoid)

  • Concurrent high‑dose amino‑acid solutions: risk of amino‑acid overload and metabolic disturbances.
  • Incompatible IV fluids containing calcium: may cause precipitation and catheter blockage.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may increase loss of electrolytes supplied by the solution.
  • Insulin therapy: can alter amino‑acid uptake and glucose metabolism.
  • Renal replacement therapy: may remove administered amino acids, reducing efficacy.
  • High‑dose corticosteroids: can affect protein catabolism and nitrogen balance.
  • Certain antiepileptic drugs: may interfere with amino‑acid metabolism.

Frequently Asked Questions

Olimel is an intravenous amino‑acid solution used as part of parenteral nutrition. It provides essential and non‑essential amino acids to patients who cannot receive enteral feeding, helping to maintain protein synthesis, nitrogen balance, and overall metabolic support during critical illness, surgery, or severe malnutrition.

The amino‑acid blend in Olimel supplies the building blocks required for protein synthesis. Once infused, the amino acids are taken up by cells, activating the mTOR pathway and other translational mechanisms that promote muscle maintenance, tissue repair, and energy production, while also supporting nitrogen balance in the body.

The dose of Olimel is individualized. A qualified prescriber determines the amount, concentration, and infusion rate based on the patient’s weight, clinical condition, renal and hepatic function, and overall nutritional requirements. No fixed regimen is provided in public documents.

Safety data for Olimel in pregnancy and lactation are limited. Because it is a parenteral nutrition product, it should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To order Olimel, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and the necessary import documentation.

Olimel offers a comprehensive amino‑acid profile that includes both essential and non‑essential amino acids, similar to other high‑quality parenteral nutrition solutions. Compared with products that contain only essential amino acids, Olimel may provide broader metabolic support, but the choice depends on the patient’s specific clinical needs and physician preference.

Olimel must be stored at 2‑8 °C. Keep the solution refrigerated, protect it from light, and avoid freezing or shaking the container. Follow the manufacturer’s labeling for any additional handling instructions to maintain product stability.

Olimel is administered intravenously, typically through a central venous catheter or a peripheral line, depending on the prescribed concentration and infusion rate. The infusion is performed under aseptic conditions, and the rate is adjusted according to the patient’s metabolic needs and clinical monitoring.

Serious risks include severe allergic reactions such as anaphylaxis, significant electrolyte disturbances, acute renal or hepatic dysfunction, and hyperammonemia. Continuous monitoring of vital signs, renal function, liver enzymes, and electrolyte levels is essential to detect and manage these potential complications promptly.

Olimel should be avoided in patients with known hypersensitivity to any of its amino‑acid components, those with inborn errors of amino‑acid metabolism, and individuals in whom parenteral nutrition is contraindicated due to severe fluid overload or uncontrolled metabolic disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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