Product image of Olivin (Enalapril Maleate) supplied by GNH India

Olivin

Active Ingredient:
Enalapril Maleate
Origin:
EU

Olivin (Enalapril Maleate)

Enalapril, the active ingredient in Olivin, is an Angiotensin-Converting Enzyme (ACE) Inhibitor presented as a tablet for oral use. It is used to manage hypertension and certain cardiac conditions in adults.

GNH India supplies Olivin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Lek Pharmaceuticals D.D. Ljubljana

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Indications & Clinical Uses

Enalapril is an ACE inhibitor that acts on the renin‑angiotensin system to lower blood pressure and protect the heart.

  • Hypertension: Helps reduce the risk of stroke and cardiovascular events by lowering blood pressure.
  • Heart failure: Improves symptoms and reduces hospital‑readmission rates in patients with reduced ejection fraction.
  • Diabetic nephropathy: Slows the progression of kidney damage in type 2 diabetes patients.

How It Works

  • Enalapril is a pro‑drug that is converted in the liver to enalaprilat, a potent inhibitor of the angiotensin‑converting enzyme. By blocking ACE, it prevents the conversion of angiotensin I to the vasoconstrictor angiotensin II, leading to vasodilation, reduced aldosterone secretion, and decreased sodium and water retention.

Side Effects

Adverse reactions to enalapril may vary in frequency and severity.

Common Side Effects

  • Cough: dry, persistent cough reported by many patients.
  • Dizziness: especially when standing up quickly.
  • Headache: mild to moderate intensity.
  • Fatigue: general feeling of tiredness.
  • Hyperkalemia: elevated blood potassium levels.
  • Renal function changes: slight increase in serum creatinine.

Serious or Rare Side Effects

  • Angio‑edema: swelling of lips, tongue, or airway requiring emergency care.
  • Severe hypotension: marked drop in blood pressure causing fainting.
  • Acute kidney injury: rapid decline in renal function.
  • Neutropenia or agranulocytosis: dangerously low white‑blood‑cell counts.
  • Hepatotoxicity: liver enzyme elevations or hepatitis.
  • Stevens‑Johnson syndrome: severe skin reaction.

Precautions & Warnings

When prescribing enalapril, clinicians should assess patient history and monitor key parameters.

  • Renal impairment: adjust dose and monitor creatinine and potassium.
  • Hyperkalemia risk: avoid concurrent potassium‑sparing diuretics or supplements.
  • Pregnancy: contraindicated in second and third trimesters due to fetal toxicity.
  • Elderly patients: start with lower dose and monitor for hypotension.
  • Drug‑induced cough: evaluate if persistent and affecting adherence.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Enalapril may interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Aliskiren: combined use can cause excessive hypotension and renal dysfunction.
  • Lithium: enalapril can increase lithium levels, raising toxicity risk.
  • NSAIDs: may blunt antihypertensive effect and worsen renal function.

Moderate Interactions (Monitor Closely)

  • Potassium‑rich foods or supplements: may exacerbate hyper‑kalaemia.
  • Diuretics (loop or thiazide): can enhance hypotensive effect, especially at therapy start.
  • Angiotensin II receptor blockers (ARBs): concurrent use increases risk of kidney injury and high potassium.

Frequently Asked Questions

Olivin contains enalapril, an ACE inhibitor that is prescribed to lower high blood pressure, treat heart failure with reduced ejection fraction, and slow the progression of kidney damage in patients with type 2 diabetes. These indications reflect its action on the renin‑angiotensin system.

Enalapril is a pro‑drug that is converted to enalaprilat, which blocks the angiotensin‑converting enzyme. This inhibition prevents formation of angiotensin II, a potent vasoconstrictor, leading to blood‑vessel relaxation, reduced aldosterone release, and lower sodium‑water retention, thereby decreasing blood pressure and cardiac workload.

The dose of Olivin is individualized by the prescribing clinician based on the patient’s condition, age, kidney function and response to therapy. The prescriber determines the appropriate strength and titration schedule according to clinical guidelines.

Enalapril is contraindicated in the second and third trimesters of pregnancy because it can cause fetal renal damage and other birth defects. Limited data exist for breastfeeding; therefore, it is generally avoided unless the benefit outweighs potential risk.

To order Olivin, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Olivin (enalapril) shares the same mechanism as other ACE inhibitors such as lisinopril or ramipril, offering comparable blood‑pressure reduction and organ‑protective effects. Choice among agents often depends on dosing convenience, patient tolerance, renal function, and formulary preferences.

Store Olivin tablets at temperatures below 25 °C in the original container, protecting them from moisture, heat and direct sunlight. Do not expose the tablets to excessive humidity or freeze them, and keep them out of reach of children.

Olivin is taken orally, usually once or twice daily as directed by the prescriber. Tablets should be swallowed whole with a glass of water and can be taken with or without food, unless the clinician advises otherwise.

Serious adverse reactions to Olivin include angio‑edema, severe hypotension, acute kidney injury, and rare blood‑cell disorders such as neutropenia. Patients should seek immediate medical attention if they experience swelling of the face or throat, fainting, or sudden loss of kidney function.

Olivin should not be used by individuals with a known hypersensitivity to enalapril or any ACE‑inhibitor, pregnant women in the second or third trimester, and patients with a history of angio‑edema related to ACE‑inhibitor therapy. Caution is also advised for those with severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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