Product image of Olmampid (Olmesartan Medoxomil, Amlodipine) supplied by GNH India

Olmampid

Active Ingredient:
Olmesartan Medoxomil, Amlodipine
Origin:
EU

Olmampid (Olmesartan Medoxomil, Amlodipine)

Olmesartan medoxomil, the active ingredient in Olmampid, is an antihypertensive presented as a tablet for oral use. It treats high blood pressure and may be used in adults requiring combined renin‑angiotensin system blockade and calcium‑channel blockade.

GNH India supplies Olmampid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

Manufacturer / TM Owner

Mylan S.P.A.

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Indications & Clinical Uses

Olmampid combines two antihypertensive agents that act on the renin‑angiotensin system and vascular smooth‑muscle tone, providing blood‑pressure control in several clinical settings.

  • Hypertension: lowers systolic and diastolic blood pressure when monotherapy is insufficient.
  • Hypertension with cardiovascular risk: improves blood‑pressure control and may reduce risk of stroke‑related events.
  • Hypertension resistant to single‑agent therapy: offers an additive effect through two complementary mechanisms.

How It Works

  • Olmesartan medoxomil blocks the angiotensin II type 1 (AT1) receptor, preventing vasoconstriction and aldosterone release, while amlodipine inhibits calcium influx into vascular smooth‑muscle cells, causing arterial dilation. The combined effect produces additive blood‑pressure reduction.

Side Effects

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

  • Peripheral edema
  • Headache
  • Dizziness
  • Flushing
  • Fatigue
  • Nausea

Serious or Rare Side Effects

  • Angio‑edema
  • Severe hypotension
  • Hepatic dysfunction
  • Acute kidney injury
  • Myocardial infarction
  • Hyperkalemia

Precautions & Warnings

Before initiating therapy, clinicians should assess patient history and monitor relevant parameters.

  • Renal impairment: adjust dose and monitor creatinine.
  • Hepatic impairment: use with caution and monitor liver enzymes.
  • Electrolyte disturbances: check potassium levels regularly.
  • Concomitant diuretics: monitor blood pressure and volume status.
  • Pregnancy: contraindicated in the second and third trimesters.

Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Olmampid may interact with several drug classes, requiring clinical vigilance.

Major Interactions (Avoid)

  • ACE inhibitors or ARBs combined with aliskiren in diabetic patients.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole) that increase amlodipine levels.
  • Lithium: risk of toxicity due to reduced renal clearance.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs) may blunt antihypertensive effect.
  • Simvastatin: amlodipine can increase statin concentration.
  • Diuretics: may enhance hypotensive response.
  • Rifampicin: may reduce amlodipine exposure.

Frequently Asked Questions

Olmampid is a fixed‑dose combination of olmesartan medoxomil and amlodipine that is prescribed to lower high blood pressure in adults, especially when a single agent does not achieve target blood‑pressure levels.

Olmesartan medoxomil is an angiotensin II receptor blocker (ARB). It selectively blocks the AT1 receptor, preventing angiotensin II‑mediated vasoconstriction and aldosterone release, which helps relax blood vessels and lower blood pressure.

The dose of Olmampid is individualized by the prescribing clinician based on the patient’s blood‑pressure readings, renal function and concomitant medications. The prescriber determines the appropriate strength and dosing schedule.

Olmesartan medoxomil is contraindicated in the second and third trimesters of pregnancy because of fetal toxicity risk. Safety in breastfeeding is not established, and the product should be used only if the benefit outweighs potential risks.

To order, submit an enquiry on the Olmampid product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Olmampid combines an ARB with a calcium‑channel blocker, offering additive blood‑pressure reduction compared with monotherapy. This dual mechanism can be more effective than either class alone and may reduce the need for multiple separate pills.

Store tablets at ambient temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the container tightly closed and out of reach of children.

Olmampid is taken orally, usually once daily, with or without food. Patients should follow the prescribing clinician’s instructions regarding timing and whether to swallow the tablet whole.

Serious adverse events can include angio‑edema, severe hypotension, acute kidney injury, hepatic dysfunction and hyper‑kalemia. Prompt medical attention is required if any of these symptoms develop.

Olmampid should be avoided in patients with known hypersensitivity to olmesartan, amlodipine or any excipients, in pregnant women (second and third trimester), and in individuals with severe hepatic or renal impairment unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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