Product image of Olmes Plus (Olmesartan Medoxomil, Hydrochlorothiazide) supplied by GNH India

Olmes Plus

Active Ingredient:
Olmesartan Medoxomil, Hydrochlorothiazide
Origin:
EU

Olmes Plus (Olmesartan Medoxomil, Hydrochlorothiazide)

Olmesartan medoxomil, the active ingredient in Olmes Plus, is an angiotensin II receptor blocker combined with a thiazide diuretic presented as a tablet for oral use. It treats hypertension in adults, often when lifestyle changes and monotherapy are insufficient.

GNH India supplies Olmes Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

Manufacturer / TM Owner

Daiichi Sankyo Europe Gmbh

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Indications & Clinical Uses

Olmes Plus is an antihypertensive medication that acts on the renin‑angiotensin‑aldosterone system to lower blood pressure.

  • Essential hypertension: helps achieve target blood pressure when monotherapy is inadequate.
  • Hypertension with fluid retention: combines ARB action with diuretic effect to reduce volume overload.
  • Diabetic nephropathy risk reduction: provides blood pressure control that can slow kidney damage progression.

How It Works

  • Olmesartan medoxomil blocks the binding of angiotensin II to the AT1 receptor on vascular smooth‑muscle and adrenal cells, preventing vasoconstriction and aldosterone release. Hydrochlorothiazide inhibits sodium‑chloride reabsorption in the distal convoluted tubule, promoting diuresis and further lowering blood pressure.

Side Effects

Olmes Plus may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Fatigue
  • Increased urination
  • Electrolyte disturbances (e.g., low potassium)
  • Mild gastrointestinal discomfort

Serious or Rare Side Effects

  • Severe hypotension
  • Acute kidney injury
  • Hyperkalemia
  • Angio‑edema involving face, lips or tongue
  • Liver enzyme elevation
  • Blood dyscrasias such as agranulocytosis

Precautions & Warnings

Before taking Olmes Plus, consider the following safety points:

  • Renal function: assess baseline kidney function and monitor periodically.
  • Electrolytes: check serum potassium and sodium levels, especially when combined with other diuretics.
  • Pregnancy: avoid use during the second and third trimesters due to fetal toxicity.
  • Concomitant drugs: review other antihypertensives or potassium‑sparing agents for additive effects.
  • Gout: monitor uric acid as thiazides can precipitate gout attacks.

Store at below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Olmes Plus can interact with several medicines; careful management is recommended.

Major Interactions (Avoid)

  • Aliskiren (in diabetic patients): may cause excessive renal impairment.
  • Lithium: increased risk of lithium toxicity.
  • Potassium‑rich supplements or potassium‑sparing diuretics: risk of hyperkalemia.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may blunt antihypertensive effect and affect renal function.
  • ACE inhibitors or other ARBs: additive blood‑pressure lowering and hyperkalemia risk.
  • Antidiabetic drugs: may require dose adjustment due to improved glycemic control.

Frequently Asked Questions

Olmes Plus is prescribed to lower high blood pressure in adults, especially when a single‑agent therapy does not achieve target levels. The combination of an angiotensin II receptor blocker and a thiazide diuretic provides both vascular relaxation and fluid reduction, helping to control hypertension effectively.

Olmesartan medoxomil selectively blocks AT1 receptors, preventing angiotensin II‑mediated vasoconstriction and aldosterone release. This results in relaxed blood vessels and reduced sodium‑water retention, which together lower systemic blood pressure.

The appropriate dose of Olmes Plus is determined by a qualified prescriber based on the patient’s blood‑pressure readings, kidney function, and overall health status. Dosage adjustments are made according to clinical response and tolerability.

Olmes Plus is contraindicated in the second and third trimesters of pregnancy because angiotensin‑II blockade can harm the developing fetus. Limited data exist for breastfeeding; therefore, the medication should be used only if the potential benefit outweighs the risk and under medical supervision.

To place an order, submit an enquiry on the Olmes Plus product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Olmes Plus combines an ARB with a thiazide diuretic, offering dual mechanisms that can be more effective than monotherapy with either class alone. Compared with ACE‑inhibitor + diuretic combos, it may have a lower incidence of cough but shares similar risks of electrolyte imbalance and renal effects.

Olmes Plus tablets should be stored at temperatures below 25 °C, in their original packaging, protected from moisture and direct sunlight. Keep the container tightly closed and out of reach of children.

Olmes Plus is taken orally, usually once daily, with or without food as directed by the prescribing clinician. Swallow the tablet whole with a glass of water; do not crush or split unless instructed.

Serious adverse events include severe hypotension, acute kidney injury, hyperkalemia, and angio‑edema. Patients should seek immediate medical attention if they experience sudden dizziness, swelling of the face or throat, or a rapid decline in kidney function.

Olmes Plus is contraindicated in individuals with known hypersensitivity to olmesartan, hydrochlorothiazide or any component of the formulation, as well as in patients with severe renal impairment, hyperkalemia, or those in the second or third trimester of pregnancy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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