Product image of Olmesartan/Amlodipin Heumann (Olmesartan Medoxomil, Amlodipine Besilate) supplied by GNH India

Olmesartan/Amlodipin Heumann

Active Ingredient:
Olmesartan Medoxomil, Amlodipine Besilate
Origin:
EU

Olmesartan/Amlodipin Heumann (Olmesartan Medoxomil, Amlodipine Besilate)

Olmesartan medoxil, the active ingredient in Olmesartan/Amlodipin Heumann, is a combination antihypertensive presented as a tablet for oral use. It treats hypertension in adults, often when monotherapy does not provide adequate blood pressure control.

GNH India supplies Olmesartan/Amlodipin Heumann as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Heumann Pharma Gmbh & Co. Generica Kg

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Indications & Clinical Uses

Olmesartan/Amlodipin Heumann is used in cardiovascular therapy to manage high blood pressure and related conditions.

  • Hypertension: Helps lower systolic and diastolic blood pressure to target levels.
  • Hypertensive heart disease: Reduces cardiac workload and risk of left‑ventricular hypertrophy.
  • Stroke prevention: Lowers the risk of cerebrovascular events in patients with elevated blood pressure.

How It Works

  • Olmesartan medoxil blocks the angiotensin II type‑1 (AT‑1) receptors, preventing vasoconstriction and aldosterone release, while amlodipine besilate inhibits calcium influx into vascular smooth‑muscle cells, producing arterial dilation. The combined effect results in reduced peripheral resistance and lower blood pressure.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Peripheral edema: mild swelling, often in the ankles.
  • Headache: transient, mild to moderate intensity.
  • Dizziness: especially upon standing quickly.
  • Flushing: warm sensation and reddening of the skin.
  • Fatigue: general feeling of tiredness.
  • Palpitations: awareness of heartbeat irregularities.

Serious or Rare Side Effects

  • Angio‑edema: rapid swelling of face, lips or throat.
  • Severe hypotension: marked drop in blood pressure causing faintness.
  • Hepatic dysfunction: abnormal liver enzyme elevations.
  • Myocardial infarction: rare occurrence of heart attack.
  • Acute kidney injury: sudden decline in renal function.
  • Blood dyscrasias: abnormal blood cell counts.

Precautions & Warnings

Before initiating therapy, clinicians should assess patient history and monitor relevant parameters.

  • Renal impairment: adjust dosing and monitor serum creatinine.
  • Hepatic impairment: use with caution; monitor liver function tests.
  • Electrolyte disturbances: check potassium and sodium levels regularly.
  • Concomitant antihypertensives: avoid excessive blood pressure reduction.
  • Pregnancy: contraindicated in the second and third trimesters; discuss risks.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Olmesartan/Amlodipin Heumann may interact with several drug classes; careful review is recommended.

Major Interactions (Avoid)

  • Potassium‑rich supplements or potassium‑sparing diuretics: risk of hyper‑kalemia.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): increase amlodipine exposure.
  • NSAIDs (high dose): may blunt antihypertensive effect and affect renal function.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance hypotensive response.
  • Lithium: monitor serum levels for potential toxicity.
  • Rifampicin: may reduce olmesartan plasma concentrations.

Frequently Asked Questions

Olmesartan/Amlodipin Heumann is a fixed‑dose combination of olmesartan medoxil and amlodipine besilate indicated for the treatment of primary hypertension, either alone or when additional blood‑pressure lowering is required beyond what a single agent can provide.

Olmesartan medoxil is an angiotensin‑II receptor blocker that selectively inhibits AT‑1 receptors, preventing angiotensin‑II‑mediated vasoconstriction and aldosterone release, which leads to relaxation of blood vessels and reduced fluid retention.

The prescribed dose is determined by the treating physician based on the patient’s blood‑pressure readings, renal function, and any concomitant medications. Dosage adjustments are made to achieve target blood‑pressure goals while minimizing adverse effects.

Olmesartan/Amlodipin Heumann is contraindicated in the second and third trimesters of pregnancy because of the risk of fetal toxicity. Limited data are available for breastfeeding; therefore, it should be used only if the potential benefit justifies the potential risk to the infant.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The fixed‑dose combination offers the same pharmacologic actions as taking olmesartan and amlodipine separately, but simplifies the regimen to a single tablet, which can improve adherence and provide consistent dosing of both agents.

Store the tablets at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Do not expose the product to excessive heat or humidity.

The medication is taken orally, usually once daily, with or without food. Patients should follow the prescribing clinician’s instructions regarding timing and whether to swallow the tablet whole.

Serious adverse events, although rare, include angio‑edema, severe hypotension, acute kidney injury, and significant liver enzyme elevations. Patients should seek immediate medical attention if they experience swelling of the face or throat, dizziness, or sudden loss of kidney function.

Individuals with known hypersensitivity to olmesartan, amlodipine, or any excipients in the tablet should avoid this product. It is also contraindicated in pregnant women during the second and third trimesters and in patients with severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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