What is Olmesartan/Amlodipine Clonmel used for?

Olmesartan/Amlodipine Clonmel

Active Ingredient:: Olmesartan Medoxomil, Amlodipine
Origin:: EU

Olmesartan/Amlodipine Clonmel (Olmesartan Medoxomil, Amlodipine)

Olmesartan medoxil, the active ingredient in Olmesartan/Amlodipine Clonmel, is an angiotensin II receptor blocker (ARB) presented as a fixed‑dose combination for oral use. It treats hypertension, often in patients who require additional blood pressure control beyond monotherapy.

GNH India supplies Olmesartan/Amlodipine Clonmel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

Manufacturer / TM Owner

Clonmel Healthcare Ltd.

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Indications & Clinical Uses

Olmesartan/Amlodipine Clonmel is used in cardiovascular therapy, targeting elevated blood pressure and related conditions.

Hypertension: Improves blood pressure control when monotherapy is insufficient.
Hypertensive heart disease: Reduces cardiac workload and risk of progression.
Chronic kidney disease with hypertension: Helps slow renal function decline associated with high blood pressure.

How It Works

Olmesartan medoxil blocks the angiotensin II type 1 (AT1) receptor, preventing vasoconstriction and aldosterone release, while amlodipine inhibits calcium influx into vascular smooth‑muscle cells, causing arterial dilation. The combined action results in reduced systemic vascular resistance and lower blood pressure.

Side Effects

Adverse reactions may occur with any antihypertensive combination therapy.

Common Side Effects

Dizziness or light‑headedness
Peripheral edema
Headache
Flushing
Fatigue
Nasal congestion

Serious or Rare Side Effects

Angio‑edema
Severe hypotension
Hepatic enzyme elevation
Jaundice
Acute kidney injury
Myocardial infarction in susceptible patients

Precautions & Warnings

When prescribing Olmesartan/Amlodipine Clonmel, clinicians should consider several safety aspects.

Monitor renal function: Assess serum creatinine and electrolytes before and during therapy.
Check potassium levels: Hyper‑kalaemia risk may increase when combined with potassium‑sparing agents.
Assess for pregnancy: Avoid use in pregnancy due to fetal toxicity.
Evaluate hepatic status: Use caution in patients with liver impairment.
Review concomitant antihypertensives: Risk of additive hypotension.
Store below 25°C: Keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Olmesartan/Amlodipine Clonmel can interact with several drug classes, requiring clinical vigilance.

Major Interactions (Avoid)

Dual renin‑angiotensin system blockade (e.g., ACE inhibitors, other ARBs): Increases risk of renal impairment and hyper‑kalaemia.
Potassium‑rich supplements or potassium‑sparing diuretics: Heightens hyper‑kalaemia risk.

Moderate Interactions (Monitor Closely)

Non‑steroidal anti‑inflammatory drugs (NSAIDs): May blunt antihypertensive effect and affect renal function.
CYP3A4 inhibitors (e.g., clarithromycin, itraconazole): Can raise amlodipine plasma levels.
Diuretics: May potentiate hypotensive response.
Lithium: May increase serum lithium concentrations.
Alcohol: Enhances vasodilatory effect, increasing dizziness.

Frequently Asked Questions

Olmesartan/Amlod5

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 04 Oct 2026

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