Product image of Olmesartan/Amlodipine/Hct Eg (Olmesartan Medoxomil, Hydrochlorothiazide, Amlodipine Besilate) supplied by GNH India

Olmesartan/Amlodipine/Hct Eg

Active Ingredient:
Olmesartan Medoxomil, Hydrochlorothiazide, Amlodipine Besilate
Origin:
EU

Olmesartan/Amlodipine/Hct Eg (Olmesartan Medoxomil, Hydrochlorothiazide, Amlodipine Besilate)

Olmesartan medoxil, the active ingredient in Olmesartan/Amlodipine/Hct Eg, is an angiotensin II receptor blocker presented as a combination tablet for oral use. It treats hypertension, often in combination with other antihypertensive agents, and may be prescribed for patients who require multiple mechanisms of blood pressure control.

GNH India supplies Olmesartan/Amlodipine/Hct Eg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Eurogenerics N.V./S.A.

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Indications & Clinical Uses

Olmesartan/Amlodipine/Hct Eg is used in the management of cardiovascular conditions that involve elevated blood pressure.

  • Hypertension: helps lower systolic and diastolic blood pressure to reduce cardiovascular risk.
  • Hypertensive heart disease: assists in decreasing cardiac workload and preventing disease progression.
  • Chronic kidney disease with hypertension: aids in slowing renal function decline associated with high blood pressure.

How It Works

  • The combination product works through three complementary actions: olmesartan medoxil blocks the angiotensin II type 1 receptor, preventing vasoconstriction and aldosterone release; amlodipine besilate inhibits calcium influx into vascular smooth‑muscle cells, producing arterial vasodilation; and hydrochlorothiazide promotes renal excretion of sodium and water, decreasing plasma volume. Together these effects produce additive blood‑pressure reduction.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Peripheral edema
  • Flushing
  • Fatigue
  • Increased urination

Serious or Rare Side Effects

  • Severe hypotension
  • Electrolyte disturbances (e.g., low potassium)
  • Acute kidney injury
  • Angio‑edema
  • Liver enzyme elevation
  • Blood cell abnormalities

Precautions & Warnings

When prescribing this combination, clinicians should consider several safety aspects.

  • Renal function: assess baseline creatinine and monitor periodically.
  • Electrolytes: check potassium and sodium levels, especially with diuretic component.
  • Pregnancy: avoid use; teratogenic risk is present.
  • Elderly patients: start at lower dose and monitor for orthostatic hypotension.
  • Drug‑induced liver disease: use cautiously in patients with hepatic impairment.

Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Olmesartan/Amlodipine/Hct Eg can interact with several drug classes; awareness helps prevent adverse events.

Major Interactions (Avoid)

  • Aliskiren: may cause excessive potassium loss and renal dysfunction when combined with an ARB.
  • Potassium‑saving diuretics or supplements: increase risk of hyperkalaemia.
  • Strong CYP3A4 inhibitors (e.g., itraconazole): raise amlodipine levels, heightening hypotension risk.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may blunt antihypertensive effect and affect renal function.
  • Lithium: concurrent use can raise lithium concentrations.
  • Other antihypertensives: additive blood‑pressure lowering may require dose adjustment.

Frequently Asked Questions

Olmesartan/Amlodipine/Hct Eg is a fixed‑dose combination indicated for the treatment of hypertension, including cases where additional blood‑pressure control is needed beyond a single agent. It may also be used in patients with hypertensive heart disease or chronic kidney disease when blood‑pressure reduction is a therapeutic goal.

Olmesartan medoxil is an angiotensin II receptor blocker that selectively inhibits the AT‑1 receptor, preventing angiotensin II‑mediated vasoconstriction and aldosterone secretion. This results in relaxed blood vessels and reduced fluid retention, contributing to lower systemic blood pressure.

The dosage is individualized by the prescribing clinician based on the patient’s blood‑pressure readings, renal function, and overall treatment plan. Physicians determine the appropriate strength and frequency according to clinical guidelines and patient response.

The combination is contraindicated in pregnancy because angiotensin‑II receptor blockers can cause fetal toxicity. Breastfeeding is not recommended unless the benefit outweighs potential risk, and the prescriber should evaluate safety for the infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with single‑agent therapy, the Olmesartan/Amlodipine/Hct Eg combo offers three mechanisms—ARB, calcium‑channel blockade, and thiazide diuresis—in one tablet, which can improve adherence and provide more consistent blood‑pressure control than adding separate pills. It is often considered when monotherapy does not achieve target pressures.

Store the tablets at ambient temperature, below 25 °C, in the original container to protect from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

The medication is taken orally, usually once daily, with or without food. Patients should swallow the tablet whole with a glass of water and follow the prescribing clinician’s instructions regarding timing and any dose adjustments.

Serious adverse events can include severe hypotension, hyperkalaemia, acute kidney injury, angio‑edema and significant electrolyte disturbances. Prompt medical attention is required if symptoms such as fainting, swelling of the face or throat, or marked changes in urine output occur.

Patients with known hypersensitivity to any component of the combination, those with severe renal impairment, hyperkalaemia, or who are pregnant should avoid this product. Clinicians should also exercise caution in elderly patients and those with hepatic disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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