Olmesartan/Amlodipine Sandoz (Olmesartan Medoxomil, Amlodipine)

Olmesartan/Amlodipine combines a renin‑angiotensin system blocker with a calcium‑channel blocker to manage high blood pressure.

• Hypertension: improves blood pressure control when monotherapy is insufficient.
• Chronic kidney disease with hypertension: slows progression by reducing intraglomerular pressure.
• Cardiovascular risk reduction in patients with hypertension and additional risk factors: contributes to lower incidence of stroke and myocardial infarction.

• Olmesartan medoxil binds selectively to the angiotensin II type 1 (AT1) receptor, preventing angiotensin II‑mediated vasoconstriction and aldosterone release. Amlodipine blocks L‑type calcium channels in vascular smooth muscle, causing dose‑dependent arterial dilation. The combined effect reduces systemic vascular resistance and cardiac afterload.

Side effects reported with the combination reflect the profile of each component.

Common Side Effects

• Peripheral edema
• Headache
• Dizziness
• Flushing
• Fatigue
• Nasal congestion

Serious or Rare Side Effects

• Angio‑edema
• Severe hypotension
• Acute kidney injury
• Hepatic enzyme elevation
• Myocardial infarction in susceptible patients
• Hyperkalemia

When prescribing Olmesartan/Amlodipine, clinicians should consider several safety aspects.

• Renal impairment: dose may need adjustment and renal function monitored.
• Hepatic impairment: use with caution; monitor liver enzymes.
• Electrolyte disturbances: watch for hyperkalemia, especially with potassium‑sparing diuretics.
• Pregnancy: contraindicated in the second and third trimesters due to fetal toxicity.
• Elderly patients: start at lower dose to reduce risk of orthostatic hypotension.
• Store at ambient temperature: keep in original packaging and protect from moisture.

• Olmesartan/Amlodine   
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