Olmesartan + Hctz Mylan (Olmesartan Medoxomil, Hydrochlorothiazide)

Olmesartan + Hctz Mylan is an antihypertensive medication that acts on the renin‑angiotensin‑aldosterone system to lower blood pressure.

• Hypertension: Reduces systolic and diastolic blood pressure in patients with primary hypertension.
• Hypertension with fluid retention: Provides additional diuretic effect to control blood pressure when edema is present.
• High‑risk cardiovascular patients: Lowers the risk of stroke and myocardial infarction associated with uncontrolled hypertension.

• Olmesartan medoxil selectively blocks the binding of angiotensin II to the AT1 receptor on vascular smooth‑muscle and adrenal cells, preventing vasoconstriction and aldosterone release. Hydrochlorothiazide inhibits sodium‑chloride reabsorption in the distal convoluted tubule, promoting diuresis and further decreasing circulating blood volume, together producing a synergistic antihypertensive effect.

Common Side Effects

• Dizziness or light‑headedness
• Headache
• Fatigue
• Cough
• Increased urination
• Electrolyte disturbances (e.g., low potassium)

Serious or Rare Side Effects

• Severe hypotension
• Acute kidney injury
• Hyperkalemia
• Angio‑edema
• Liver function abnormalities
• Blood cell disorders such as agranulocytosis

Olmesartan + Hctz Mylan should be used with caution in patients with renal or hepatic impairment, and dose adjustments may be required.

• Renal function monitoring: Check serum creatinine and electrolytes before initiating therapy and periodically thereafter.
• Electrolyte balance: Monitor potassium and sodium levels, especially when combined with other diuretics.
• Pregnancy: Contraindicated in the second and third trimesters due to risk of fetal toxicity.
• Elderly patients: Start with a lower dose and titrate slowly to avoid orthostatic hypotension.
• Store at below 25°C: Keep in the original container, protect from moisture and light.

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