Product image of Olmesartan Macleods (Olmesartan Medoxomil) supplied by GNH India

Olmesartan Macleods

Active Ingredient:
Olmesartan Medoxomil
Origin:
EU

Olmesartan Macleods (Olmesartan Medoxomil)

Olmesartan medoxil, the active ingredient in Olmesartan Macleods, is an Angiotensin II receptor blocker (ARB) presented as a tablet for oral use. It treats hypertension and is indicated for use in adult patients who require blood pressure control.

GNH India supplies Olmesartan Macleods as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Macleods Pharma España, S.L.U

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Indications & Clinical Uses

Olmesartan Macleods is an ARB that lowers blood pressure by blocking the renin‑angiotensin system.

  • Hypertension: helps achieve target blood pressure and reduces cardiovascular risk.
  • Heart failure (post‑myocardial infarction): supports improved cardiac function when combined with standard therapy.
  • Diabetic nephropathy: slows progression of kidney damage associated with type 2 diabetes.

How It Works

  • Olmesartan medoxil is a selective antagonist of the angiotensin II type 1 (AT1) receptor. By preventing angiotensin II from binding to this receptor, it inhibits vasoconstriction, aldosterone release, and sympathetic activation, leading to relaxation of vascular smooth muscle and a reduction in systemic vascular resistance and arterial pressure.

Side Effects

Olmesartan Macleods may cause a range of adverse reactions.

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Fatigue
  • Nasal congestion
  • Diarrhoea
  • Cough

Serious or Rare Side Effects

  • Angio‑edema (swelling of face, lips, tongue)
  • Severe hypotension
  • Acute kidney injury
  • Hyperkalemia (elevated potassium)
  • Liver enzyme elevations
  • Myocardial infarction (rare)

Precautions & Warnings

When prescribing Olmesartan Macleods, clinicians should consider several safety aspects.

  • Renal function monitoring: assess baseline creatinine and eGFR before initiating therapy.
  • Electrolyte balance: check serum potassium periodically, especially if combined with potassium‑sparing diuretics.
  • Pregnancy: avoid use during the second and third trimesters due to fetal toxicity.
  • Concomitant NSAID use: may blunt antihypertensive effect and increase renal risk.
  • Hypersensitivity: discontinue if rash or angio‑edema develops.
  • Store at below 25°C: keep in the original packaging, protect from moisture and light.

Avoid Interactions

Olmesartan Macleods can interact with several medicines, requiring attention to dosage and monitoring.

Major Interactions (Avoid)

  • Dual renin‑angiotensin system blockade (e.g., ACE inhibitors, other ARBs): increased risk of hyperkalaemia and renal impairment.
  • Potassium‑rich supplements or salt substitutes: may cause dangerous hyperkalaemia.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may reduce antihypertensive efficacy and affect renal function.
  • Diuretics (especially thiazides): may enhance hypotensive effect.
  • Lithium: can increase serum lithium levels, risking toxicity.
  • Antifungal azoles (e.g., ketoconazole): may raise olmesartan concentrations.
  • CYP3A4 inhibitors (e.g., clarithromycin): modestly increase exposure.

Frequently Asked Questions

Olmesartan Macleods is a generic formulation of olmesartan medoxil that belongs to the angiotensin II receptor blocker class. It is primarily prescribed to lower high blood pressure in adults and may be part of combination therapy for heart failure or diabetic kidney disease when approved by a clinician.

Olmesartan medoxil selectively blocks the angiotensin II type‑1 (AT1) receptor, preventing angiotensin II‑induced vasoconstriction and aldosterone release. This leads to relaxation of blood vessels, reduced peripheral resistance and ultimately lower arterial blood pressure.

The dosage of Olmesartan Macleods is individualized by the prescribing healthcare professional based on the patient’s blood pressure, response to therapy and any co‑existing medical conditions. The prescriber determines the appropriate strength and dosing schedule.

Olmesartan Macleods is contraindicated in the second and third trimesters of pregnancy because it can cause fetal toxicity. Limited data are available for breastfeeding; therefore, it should only be used if the potential benefit justifies the possible risk to the infant.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Olmesartan, as an ARB, provides blood‑pressure reduction comparable to ACE inhibitors but with a lower incidence of cough and angio‑edema. Compared with calcium‑channel blockers or diuretics, it works through the renin‑angiotensin system and is often chosen when those agents are insufficient or not tolerated.

Store Olmesartan Macleods tablets at temperatures below 25 °C in their original container, protected from moisture and direct light. Do not refrigerate or freeze the tablets, and keep them out of reach of children.

Olmesartan Macleods is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed by a healthcare professional.

Serious adverse events include angio‑edema, severe hypotension, acute kidney injury and hyperkalaemia. Patients should be monitored for signs of swelling, sudden drops in blood pressure, changes in kidney function or elevated potassium levels, especially when used with other renin‑angiotensin drugs.

Olmesartan Macleods should be avoided in patients with known hypersensitivity to olmesartan or any tablet excipients, in pregnant women during the second and third trimesters, and in individuals receiving concurrent therapy with another ARB or ACE inhibitor unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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