Product image of Olmesartán/Amlodipino Pensa (Olmesartan Medoxomil, Amlodipine) supplied by GNH India

Olmesartán/Amlodipino Pensa

Active Ingredient:
Olmesartan Medoxomil, Amlodipine
Origin:
EU

Olmesartán/Amlodipino Pensa (Olmesartan Medoxomil, Amlodipine)

Olmesartan medoxomil and amlodipine, the active ingredient in Olmesartán/Amlodipino Pensa, is an angiotensin II receptor blocker / calcium channel blocker presented as a tablet for oral use. It treats hypertension in adult patients.

GNH India supplies Olmesartán/Amlodipino Pensa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Towa Pharmaceutical S.A.

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Indications & Clinical Uses

  • Olmesartan medoxomil and amlodipine act together to lower elevated blood pressure in the cardiovascular system.
  • Hypertension: reduces systolic and diastolic blood pressure, helping to prevent stroke, myocardial infarction and other cardiovascular complications.

How It Works

  • Olmesartan medoxomil selectively blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and aldosterone release. Amlodipine inhibits L‑type calcium channels in vascular smooth muscle, causing arterial vasodilation. The combined effect results in decreased peripheral resistance and lowered blood pressure.

Side Effects

Common Side Effects

  • Headache: mild to moderate intensity.
  • Peripheral edema: swelling of ankles or feet.
  • Dizziness or light‑headedness, especially after standing.
  • Flushing: transient warmth and redness.
  • Fatigue: general feeling of tiredness.
  • Gastrointestinal discomfort: nausea or abdominal pain.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, tongue, or throat.
  • Severe hypotension: markedly low blood pressure causing fainting.
  • Hepatic dysfunction: abnormal liver enzymes or jaundice.
  • Cardiac arrhythmias: irregular heart rhythm.
  • Allergic reactions: rash, itching, or severe skin reactions.

Precautions & Warnings

Before initiating therapy, consider patient‑specific factors and monitor appropriately.

  • Renal impairment: assess kidney function and adjust dose if needed.
  • Hepatic disease: use with caution; monitor liver enzymes.
  • Concomitant antihypertensives: avoid excessive blood pressure drop.
  • Pregnancy and lactation: avoid use unless clearly indicated by a physician.
  • Elderly patients: start at lower dose and monitor for orthostatic hypotension.
  • Store at room temperature: keep below 25 °C, in the original container, protected from moisture and light.

Avoid Interactions

Drug interactions may alter efficacy or increase risk of adverse events.

Major Interactions (Avoid)

  • Dual renin‑angiotensin system blockade (e.g., ACE inhibitors, ARBs): risk of hyperkalemia and renal dysfunction.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): increase amlodipine plasma levels.
  • Lithium: may increase lithium concentrations, leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Diuretics: may potentiate hypotensive effect; monitor blood pressure.
  • NSAIDs: can reduce antihypertensive efficacy and affect renal function.
  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may lower amlodipine levels, reducing effectiveness.

Frequently Asked Questions

Olmesartán/Amlodipino Pensa is a fixed‑dose combination of olmesartan medoxomil and amlodipine indicated for the treatment of hypertension in adult patients. It helps lower blood pressure and reduces the risk of cardiovascular events.

Olmesartan medoxomil blocks angiotensin II type 1 (AT1) receptors, preventing the hormone from causing vasoconstriction and aldosterone release. This leads to relaxation of blood vessels and a reduction in blood pressure.

Amlodipine inhibits L‑type calcium channels in vascular smooth muscle, which reduces calcium influx and causes arterial vasodilation. The resulting decrease in peripheral resistance contributes to lower blood pressure.

The appropriate dose is determined by the prescribing clinician based on the patient’s clinical condition, response to therapy, and any concomitant medications. No fixed regimen is provided here.

Safety in pregnancy and lactation has not been established. The product should be avoided unless the potential benefit justifies the potential risk, and only under medical supervision.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

This combination offers dual mechanisms—AT1‑receptor blockade and calcium‑channel inhibition—in a single tablet, which can improve adherence compared with separate agents. It is often preferred when monotherapy does not achieve target blood pressure.

Store the tablets at room temperature, below 25 °C, in the original packaging. Protect them from moisture, heat and direct sunlight to maintain stability.

The product is taken orally, usually once daily, with or without food, as directed by the prescribing healthcare professional.

Serious adverse reactions can include angioedema, severe hypotension, hepatic dysfunction, and cardiac arrhythmias. Patients should seek immediate medical attention if they experience swelling of the face or throat, fainting, jaundice, or irregular heartbeats.

Patients with known hypersensitivity to olmesartan, amlodipine, or any excipients, as well as those with severe hepatic impairment, should avoid this medication. It is also contraindicated in pregnancy unless clearly indicated by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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