Product image of Olmesartán/Amlodipino Viatris (Olmesartan Medoxomil, Amlodipine) supplied by GNH India

Olmesartán/Amlodipino Viatris

Active Ingredient:
Olmesartan Medoxomil, Amlodipine
Origin:
EU

Olmesartán/Amlodipino Viatris (Olmesartan Medoxomil, Amlodipine)

Olmesartan medoxil, the active ingredient in Olmesartan/Amlodipine Viatris, is an angiotensin II receptor blocker presented as a tablet for oral use. It lowers blood pressure in adults with hypertension, often combined with amlodipine, a calcium‑channel blocker, to improve control. The combination is indicated for patients whose blood pressure is not adequately controlled with monotherapy.

GNH India supplies Olmesartan/Amlodipine Viatris as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Pharmaceuticals, S.L.U.

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Indications & Clinical Uses

  • Olmesartan/Amlodipine is a combination antihypertensive that targets the renin‑angiotensin system and calcium channels to manage high blood pressure.
  • Essential hypertension: provides additive blood‑pressure reduction when monotherapy is insufficient.
  • High‑risk hypertension: improves control in patients with additional cardiovascular risk factors.
  • Resistant hypertension: offers an oral dual‑action option for patients needing multiple agents.

How It Works

  • Olmesartan medoxil blocks the angiotensin II type 1 (AT1) receptor, preventing vasoconstriction and aldosterone release, while amlodipine inhibits calcium influx into vascular smooth‑muscle cells, causing arterial dilation. The complementary actions result in reduced systemic vascular resistance and lower arterial pressure.

Side Effects

The combination may cause a range of adverse reactions, from frequent to rare.

Common Side Effects

  • Dizziness: light‑headed feeling, especially after standing.
  • Headache: mild to moderate intensity.
  • Peripheral edema: swelling of the ankles or feet.
  • Flushing: transient warmth and redness of the skin.

Serious or Rare Side Effects

  • Angioedema: rapid swelling of face, lips, tongue, or airway.
  • Severe hypotension: marked drop in blood pressure causing faintness.
  • Hepatic dysfunction: abnormal liver enzymes or jaundice.

Precautions & Warnings

  • When using Olmesartan/Amlodipine, certain safety measures should be observed.
  • Blood pressure monitoring: check regularly to avoid hypotension.
  • Pregnancy: avoid use because of fetal risk.
  • Renal impairment: adjust dose and monitor function.
  • Electrolyte balance: watch for hyperkalemia when combined with potassium‑sparing agents.
  • Concomitant CYP3A4 inhibitors: may increase amlodipine levels; monitor.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Olmesartan/Amlodipine can interact with several medicines; awareness helps maintain efficacy and safety.

Major Interactions (Avoid)

  • Aliskiren (in diabetic patients): combined use can cause renal impairment and hyperkalemia.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): increase amlodipine exposure, raising risk of hypotension.
  • Potassium‑sparing diuretics (e.g., spironolactone): may raise potassium levels when used with olmesartan.

Moderate Interactions (Monitor Closely)

  • Other antihypertensives (beta‑blockers, diuretics): additive blood‑pressure lowering effect.
  • NSAIDs: may reduce antihypertensive efficacy of olmesartan.
  • Lithium: may increase lithium levels; monitor serum concentration.

Frequently Asked Questions

Olmesartan/Amlodipine is a fixed‑dose combination antihypertensive indicated for the treatment of essential hypertension, especially when a single agent does not achieve target blood‑pressure levels.

Olmesartan blocks the angiotensin II type 1 receptor, preventing vasoconstriction and aldosterone‑mediated fluid retention, which lowers systemic vascular resistance and blood pressure.

The prescribed dose is determined by the treating physician based on the patient’s clinical condition, blood‑pressure response, and any concomitant therapies.

The combination is contraindicated in pregnancy because of potential fetal harm. Limited data are available for breastfeeding; the decision should be made by a healthcare professional weighing benefits and risks.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Compared with monotherapy, the combination offers additive blood‑pressure reduction, simplifying regimens and improving adherence. It provides a similar efficacy to other ARB‑CCB combos but may differ in tolerability profiles.

Store the tablets at ambient temperature, below 25 °C, in the original packaging, protected from moisture, light and excessive heat to maintain stability.

The medication is taken orally, usually once daily, with or without food, as directed by the prescribing clinician.

Serious adverse events include angioedema, severe hypotension and hepatic dysfunction. Patients should seek immediate medical attention if they experience swelling of the face, lips, tongue, or difficulty breathing.

The combination should be avoided in patients with known hypersensitivity to either component, in pregnant women, and in individuals with severe hepatic impairment or uncontrolled heart failure unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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