Product image of Olmesartan Medoxomil/Amlodipine/Hydrochlorothiazide Teva (Olmesartan Medoxomil, Hydrochlorothiazide, Amlodipine Besilate) supplied by GNH India

Olmesartan Medoxomil/Amlodipine/Hydrochlorothiazide Teva

Active Ingredient:
Olmesartan Medoxomil, Hydrochlorothiazide, Amlodipine Besilate
Origin:
EU

Olmesartan Medoxomil/Amlodipine/Hydrochlorothiazide Teva (Olmesartan Medoxomil, Hydrochlorothiazide, Amlodipine Besilate)

Olmesartan medoxomil, amlodipine besilate and hydrochlorothiazide, the active ingredients in Olmesartan Medoxomil/Amlodipine/Hydrochlorothiazide Teva, are a combination antihypertensive presented as a tablet formulation for oral use. They are indicated for the management of high blood pressure in adult patients, helping to lower cardiovascular risk.

GNH India supplies Olmesartan Medoxomil/Amlodipine/Hydrochlorothiazide Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Olmesartan medoxomil/amlodipine besilate/hydrochlorothiazide is a combination antihypertensive used to treat hypertension through multiple mechanisms.

  • Essential hypertension: lowers systolic and diastolic blood pressure when monotherapy is insufficient.
  • Secondary hypertension: provides additional control in patients with hypertension due to renal or endocrine causes.
  • Hypertension with fluid retention: combines vasodilation and diuresis to reduce blood volume and vascular resistance.

How It Works

  • Olmesartan medoxomil blocks AT1 receptors, preventing angiotensin II‑mediated vasoconstriction; amlodipine besilate inhibits L‑type calcium channels in vascular smooth muscle, causing arterial dilation; hydrochlorothiazide reduces NaCl reabsorption in the distal convoluted tubule, promoting diuresis and decreasing plasma volume, together producing a synergistic antihypertensive effect.

Side Effects

Common Side Effects

  • Dizziness or light‑headedness, especially after the first dose.
  • Headache, often mild and transient.
  • Peripheral edema, typically swelling of the ankles.
  • Flushing or warmth sensation.

Serious or Rare Side Effects

  • Angioedema or severe swelling of the face, lips, or throat.
  • Marked hypotension leading to fainting.
  • Acute renal impairment or significant rise in serum creatinine.
  • Electrolyte disturbances such as severe hyponatremia or hyperkalemia.
  • Hepatic dysfunction presenting as jaundice or elevated liver enzymes.

Precautions & Warnings

Before initiating therapy, patients should be evaluated for renal function, electrolyte balance, and potential drug interactions.

  • Blood pressure monitoring: check regularly to avoid excessive hypotension.
  • Renal function assessment: evaluate serum creatinine and eGFR before and during treatment.
  • Electrolyte surveillance: monitor potassium and sodium levels, especially with diuretic component.
  • Pregnancy and lactation: avoid use unless clearly needed, as safety data are limited.
  • Hepatic impairment: use with caution in patients with severe liver disease.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Olmesartan medoxomil/amlodipine besilate/hydrochlorothiazide may interact with several drug classes.

Major Interactions (Avoid)

  • Aliskiren in diabetic patients: increased risk of renal dysfunction and hyperkalemia.
  • Potassium‑sparing diuretics or supplements: may cause dangerous hyperkalemia.
  • Lithium: concomitant use can raise lithium levels and toxicity.
  • NSAIDs: can blunt antihypertensive effect and impair renal function.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or other ARBs: additive blood‑pressure lowering effect, monitor for hypotension.
  • CYP3A4 inhibitors (e.g., clarithromycin, itraconazole): may increase amlodipine concentrations.
  • CYP2C9 inhibitors (e.g., fluconazole): can raise hydrochlorothiazide levels, watch electrolytes.

Frequently Asked Questions

Olmesartan Medoxomil/Amlodipine/Hydrochlorothiazide Teva is a fixed‑dose combination tablet indicated for the treatment of hypertension in adult patients. By combining an angiotensin II receptor blocker, a calcium‑channel blocker, and a thiazide diuretic, it provides a comprehensive approach to lowering blood pressure when single‑agent therapy is insufficient.

Olmesartan blocks AT1 receptors, preventing angiotensin II‑induced vasoconstriction. Amlodipine inhibits L‑type calcium channels in vascular smooth muscle, causing arterial dilation. Hydrochlorothiazide reduces sodium and chloride reabsorption in the distal convoluted tubule, promoting diuresis and decreasing plasma volume. Together, these actions lower systemic vascular resistance and blood volume, resulting in reduced blood pressure.

The specific dose of Olmesartan Medoxomil/Amlodipine/Hydrochlorothiazide Teva is determined by the prescribing clinician based on the patient’s blood‑pressure goals, previous therapy, and individual health status. The prescriber will select the appropriate strength and dosing schedule according to clinical guidelines and patient response.

Safety data for the combination in pregnancy and lactation are limited. It is generally advised to avoid use during pregnancy unless the potential benefit justifies the risk. Breastfeeding mothers should consult their healthcare provider, as the drugs may be excreted in breast milk and could affect the infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details (including any special handling), and assists with import documentation.

Compared with single‑agent therapies, this triple‑component tablet offers broader blood‑pressure control by targeting three complementary pathways, often reducing the need for multiple separate pills. It may be more convenient than prescribing separate ARB, calcium‑channel blocker, and diuretic tablets, but clinicians must consider individual patient tolerance, potential drug interactions, and cost when selecting therapy.

Store the tablets at room temperature, below 25 °C, in the original packaging. Keep them away from moisture, direct sunlight, and excessive heat to maintain stability and potency throughout the shelf life.

The medication is taken orally, usually once daily, with or without food, as directed by the prescribing physician. Swallow the tablet whole with a glass of water; do not crush, chew, or split the tablet unless specifically instructed.

Serious risks include angioedema, severe hypotension, acute renal impairment, significant electrolyte disturbances (such as hyperkalemia or hyponatremia), and hepatic dysfunction. Patients should be educated to seek immediate medical attention if they experience swelling of the face or throat, sudden dizziness, fainting, or signs of kidney or liver injury.

The drug should be avoided in patients with known hypersensitivity to any of its components, severe hepatic impairment, or in those with conditions that predispose to marked hypotension. Caution is also advised for individuals with severe renal dysfunction, pregnancy, or lactation without a clear clinical justification.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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