Product image of Olmesartan Medoxomil Crescent Pharma (Olmesartan Medoxomil) supplied by GNH India

Olmesartan Medoxomil Crescent Pharma

Active Ingredient:
Olmesartan Medoxomil
Origin:
EU

Olmesartan Medoxomil Crescent Pharma (Olmesartan Medoxomil)

Olmesartan medoxil, the active ingredient in Olmesartan Medoxomil Crescent Pharma, is an Angiotensin II receptor blocker (ARB) presented as a tablet for oral use. It is indicated for the management of hypertension in adult patients. GNH India supplies Olmesartan Medoxomil Crescent Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

GNH India supplies Olmesartan Medoxomil Crescent Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Crescent Pharma Limited

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Indications & Clinical Uses

Olmesartan Medoxil is an ARB that lowers blood pressure by blocking the renin‑angiotensin system.

  • Hypertension: helps achieve target blood pressure and reduces cardiovascular risk.
  • Diabetic nephropathy: slows progression of kidney damage associated with diabetes.
  • Heart failure: used as part of combination therapy to improve outcomes in patients with reduced ejection fraction.

How It Works

  • Olmesartan medoxil is a prodrug that is rapidly converted to olmesartan, a selective antagonist of the angiotensin II type 1 (AT1) receptor. By blocking AT1 receptors, it prevents angiotensin II‑mediated vasoconstriction, aldosterone secretion, and sympathetic activation, resulting in vasodilation, reduced sodium and water retention, and lower systemic blood pressure.

Side Effects

Olmesartan Medoxil is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Dizziness
  • Headache
  • Fatigue
  • Nasal congestion
  • Diarrhea

Serious or Rare Side Effects

  • Angio‑edema
  • Hyperkalemia
  • Acute kidney injury
  • Severe hypotension
  • Liver enzyme elevations

Precautions & Warnings

When prescribing Olmesartan Medoxil, clinicians should consider several safety aspects.

  • Renal function: assess baseline kidney function and monitor periodically.
  • Electrolytes: check serum potassium, especially if combined with potassium‑sparing diuretics.
  • Pregnancy: contraindicated in the second and third trimesters due to fetal toxicity.
  • Elderly patients: start at lower dose and monitor for orthostatic hypotension.
  • Drug interactions: review concomitant medications that affect the renin‑angiotensin system.
  • Store at below 25°C: keep in the original packaging, protect from moisture and light.

Avoid Interactions

Olmesartan Medoxil may interact with several medicines that influence blood pressure or renal function.

Major Interactions (Avoid)

  • Aliskiren (in diabetic patients): increased risk of renal impairment, hyperkalemia, and hypotension.
  • Potassium‑sparing diuretics (e.g., spironolactone): risk of hyperkalemia.

Moderate Interactions (Monitor Closely)

  • NSAIDs (e.g., ibuprofen): may blunt antihypertensive effect and affect renal function.
  • ACE inhibitors or other ARBs: additive hypotensive effect, monitor blood pressure.
  • Lithium: may increase serum lithium levels, monitor for toxicity.

Frequently Asked Questions

Olmesartan Medoxil is an angiotensin II receptor blocker indicated primarily for the treatment of hypertension. It helps lower elevated blood pressure and is also used in certain patients with diabetic kidney disease or chronic heart failure as part of combination therapy.

Olmesartan medoxil is a pro‑drug that is converted in the body to olmesartan, which selectively blocks the angiotensin II type‑1 (AT1) receptor. This inhibition prevents vasoconstriction and aldosterone release, leading to relaxed blood vessels, reduced fluid retention, and lower blood pressure.

The dose of Olmesartan Medoxil is individualized by the prescribing clinician based on the patient’s blood pressure, renal function, and response to therapy. The prescriber determines the appropriate strength and titration schedule.

Olmesartan Medoxil is contraindicated in pregnancy, especially in the second and third trimesters, because it can cause fetal toxicity. Limited data are available for breastfeeding; therefore, it is generally avoided unless the benefit outweighs potential risk.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Olmesartan belongs to the ARB class, which provides blood‑pressure reduction similar to ACE inhibitors but with a lower incidence of cough and angio‑edema. Compared with calcium‑channel blockers, ARBs act on the renin‑angiotensin system rather than directly relaxing vascular smooth muscle.

Store tablets at temperatures below 25 °C in their original container, protected from moisture and light. Do not expose the product to excessive heat or humidity to maintain potency.

Olmesartan Medoxil tablets are taken orally, usually once daily, with or without food. Patients should follow the prescribing clinician’s instructions regarding timing and whether the medication should be taken with meals.

Serious adverse events include angio‑edema, severe hypotension, acute kidney injury, and hyperkalemia. Patients should seek immediate medical attention if they experience swelling of the face, lips, tongue, or difficulty breathing.

Olmesartan Medoxil should not be used by individuals with known hypersensitivity to olmesartan or any tablet excipients, pregnant women in the second or third trimester, and patients with severe renal artery stenosis or those taking aliskiren concomitantly in diabetes.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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