Product image of Olmesartan Medoxomil E Idroclorotiazide Hcs (Olmesartan Medoxomil, Hydrochlorothiazide) supplied by GNH India

Olmesartan Medoxomil E Idroclorotiazide Hcs

Active Ingredient:
Olmesartan Medoxomil, Hydrochlorothiazide
Origin:
EU

Olmesartan Medoxomil E Idroclorotiazide Hcs (Olmesartan Medoxomil, Hydrochlorothiazide)

Olmesartan medoxomil, the active ingredient in Olmesartan Medoxomil E Idroclorotiazide Hcs, is an angiotensin II receptor blocker presented as a combination tablet for oral use. It treats hypertension, often in adults who require additional blood pressure control beyond monotherapy. GNH India supplies Olmesartan Medoxomil E Idroclorotiazide Hcs as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

GNH India supplies Olmesartan Medoxomil E Idroclorotiazide Hcs as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

Manufacturer / TM Owner

Hcs Bvba

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Indications & Clinical Uses

Olmesartan medoxomil/hydrochlorothiazide is indicated for management of high blood pressure within the renin‑angiotensin‑aldosterone system pathway.

  • Hypertension: lowers systolic and diastolic pressure to reduce cardiovascular risk.
  • Hypertensive patients with fluid retention: adds diuretic effect to improve blood pressure control.
  • Resistant hypertension: provides combined ARB and thiazide action when single‑agent therapy is insufficient.

How It Works

  • Olmesartan medoxomil selectively blocks the angiotensin II type 1 (AT1) receptor, preventing vasoconstriction and aldosterone release, while hydrochlorothiazide inhibits sodium‑chloride reabsorption in the distal convoluted tubule, promoting diuresis. The combined actions reduce peripheral vascular resistance and plasma volume, resulting in lowered blood pressure.

Side Effects

Olmesartan medoxomil/hydrochlorothiazide may cause a range of adverse reactions.

Common Side Effects

  • Dizziness or light‑headedness.
  • Headache.
  • Fatigue.
  • Increased urination.
  • Electrolyte disturbances (e.g., low potassium).
  • Mild gastrointestinal upset.

Serious or Rare Side Effects

  • Severe hypotension.
  • Acute kidney injury.
  • Hyperkalemia or severe electrolyte imbalance.
  • Angio‑edema.
  • Liver function abnormalities.
  • Blood dyscrasias such as agranulocytosis.

Precautions & Warnings

When prescribing Olmesartan medoxomil/hydrochlorothiazide, clinicians should consider several safety aspects.

  • Pregnancy: contraindicated due to risk of fetal toxicity; avoid in all trimesters.
  • Renal impairment: monitor kidney function and adjust therapy as needed.
  • Electrolyte balance: check serum potassium and sodium regularly.
  • Concomitant NSAIDs: may reduce antihypertensive effect and affect renal function.
  • Gout: thiazide component can increase serum uric acid; monitor patients with a history of gout.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in the original packaging.

Avoid Interactions

Olmesartan medoxomil/hydrochlorothiazide interacts with several drug classes that may alter its efficacy or safety.

Major Interactions (Avoid)

  • Potassium‑sparing diuretics or supplements: risk of hyperkalemia.
  • Lithium: increased lithium levels and potential toxicity.
  • ACE inhibitors or other ARBs: additive hypotensive effect and renal risk.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may blunt blood‑pressure reduction and affect renal function.
  • Antidiabetic agents: diuretic‑induced hypokalemia can modify glucose control.
  • Antimicrobials such as trimethoprim‑sulfamethoxazole: may increase risk of hyperkalemia.

Frequently Asked Questions

Olmesartan Medoxomil E Idroclorotiazide Hcs is a fixed‑dose combination of an angiotensin II receptor blocker and a thiazide diuretic that is used to lower high blood pressure in adults, especially when a single agent does not provide adequate control.

Olmesartan medoxomil blocks the AT1 receptor for angiotensin II, preventing vasoconstriction and aldosterone release, while hydrochlorothiazide reduces sodium and water reabsorption in the kidney, together producing a synergistic drop in blood pressure.

The appropriate dose is determined by the prescribing clinician based on the patient’s blood‑pressure readings, renal function, and overall health status; patients should follow the prescriber’s specific instructions.

Olmesartan medoxomil is contraindicated in pregnancy because it can cause fetal harm, and the combination is not recommended for breastfeeding mothers without medical supervision.

To order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with monotherapy, the Olmesartan/hydrochlorothiazide combo offers dual mechanisms—vascular relaxation and diuresis—allowing better blood‑pressure control in patients who need more than one class of drug, while reducing pill burden versus taking two separate tablets.

Store the tablets at ambient temperature, below 25 °C, in the original container, protected from moisture and direct light to maintain potency.

The medication is taken orally, usually once daily, with or without food, as directed by a healthcare professional.

Serious risks include severe hypotension, acute kidney injury, hyperkalemia, angio‑edema and liver function abnormalities; patients should seek immediate medical attention if they experience symptoms such as swelling, rapid weight loss, or jaundice.

Individuals with known hypersensitivity to olmesartan, hydrochlorothiazide, or any component of the formulation, pregnant women, and patients with severe renal impairment or uncontrolled electrolyte disorders should avoid this product.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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