Product image of Olmesartán/ Hidroclorotiazida Jubilant (Olmesartan Medoxomil, Hydrochlorothiazide) supplied by GNH India

Olmesartán/ Hidroclorotiazida Jubilant

Active Ingredient:
Olmesartan Medoxomil, Hydrochlorothiazide
Origin:
EU

Olmesartán/ Hidroclorotiazida Jubilant (Olmesartan Medoxomil, Hydrochlorothiazide)

Olmesartan medoxomil / Hydrochlorothiazide, the active ingredient in Olmesartán/ Hidroclorotiazida Jubilant, is an angiotensin II receptor blocker / thiazide diuretic presented as a tablet for oral use. It is indicated for the treatment of hypertension in adult patients.

GNH India supplies Olmesartán/ Hidroclorotiazida Jubilant as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company follows stringent quality‑assurance protocols and adheres to EU‑GMP standards, ensuring product integrity throughout the supply chain. Products are shipped with appropriate documentation to meet regulatory requirements of each destination country.

Manufacturer / TM Owner

Jubilant Pharmaceuticals Nv

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Indications & Clinical Uses

Olmesartan medoxomil / Hydrochlorothiazide is used to manage hypertension by targeting the renin‑angiotensin system and promoting diuresis.

  • Hypertension: reduces elevated systolic and diastolic blood pressure.
  • Essential hypertension: provides long‑term blood pressure control.
  • Secondary hypertension: assists in managing blood pressure when caused by other conditions.

How It Works

  • Olmesartan medoxomil selectively blocks the angiotensin II type 1 (AT1) receptor, preventing vasoconstriction and aldosterone release. Hydrochlorothiazide inhibits sodium‑chloride reabsorption in the distal convoluted tubule, increasing urinary excretion of water and electrolytes, which lowers plasma volume and contributes to blood‑pressure reduction.

Side Effects

Common Side Effects

  • Dizziness or light‑headedness.
  • Headache.
  • Fatigue or weakness.
  • Increased urination.
  • Electrolyte disturbances such as low potassium.
  • Dry mouth.

Serious or Rare Side Effects

  • Angioedema or severe swelling.
  • Marked hypotension.
  • Acute renal impairment.
  • Hyperkalemia.
  • Severe allergic reactions (rash, Stevens‑Johnson syndrome).
  • Pancreatitis.

Precautions & Warnings

Patients should be monitored regularly for blood‑pressure response and renal function.

  • Monitor blood pressure: ensure therapeutic target is achieved.
  • Assess renal function: check serum creatinine and eGFR periodically.
  • Check electrolytes: especially potassium and sodium levels.
  • Avoid use in pregnancy: drug is classified Category D.
  • Use caution in elderly patients: increased risk of hypotension.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protected from moisture.

Avoid Interactions

Major Interactions (Avoid)

  • Potassium‑sparing diuretics: may cause hyperkalemia.
  • ACE inhibitors or other ARBs: increase risk of renal dysfunction and hyperkalemia.
  • NSAIDs: can reduce antihypertensive effect and impair renal function.

Moderate Interactions (Monitor Closely)

  • Lithium: may increase lithium levels and toxicity.
  • Other antihypertensives: additive blood‑pressure lowering effect.
  • Corticosteroids: may counteract diuretic effect.
  • Digoxin: altered serum levels due to electrolyte changes.

Frequently Asked Questions

Olmesartan medoxomil / Hydrochlorothiazide is prescribed to lower high blood pressure in adult patients. The combination works by relaxing blood vessels and increasing urine output, which together help achieve and maintain target blood‑pressure levels.

Olmesartan medoxomil blocks the angiotensin II type 1 (AT1) receptor, preventing the hormone from causing blood‑vessel constriction and aldosterone release. This results in vasodilation and reduced fluid retention, contributing to lower blood pressure.

The specific dose is determined by the prescribing clinician based on the patient’s blood‑pressure readings, kidney function, and overall health. Dosage adjustments are made during treatment to achieve optimal control.

The combination is classified as Pregnancy Category D, indicating potential risk to the fetus, and should be avoided during pregnancy. Safety during breastfeeding has not been established, so use is generally discouraged unless the benefit outweighs the risk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Olmesartan medoxomil / Hydrochlorothiazide combines an ARB with a thiazide diuretic, offering dual mechanisms that can be more effective than monotherapy. Compared with ACE inhibitors or calcium‑channel blockers, the combination may provide better blood‑pressure reduction in some patients, but individual response varies.

Store the tablets at ambient temperature, preferably below 25 °C. Keep them in the original blister pack or container, protected from moisture and direct sunlight, to maintain stability and potency throughout their shelf life.

The medication is taken orally, usually once daily, with or without food, as directed by the prescribing healthcare professional. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed.

Serious adverse events include angioedema, severe hypotension, acute kidney injury, and hyperkalemia. Patients should seek immediate medical attention if they experience swelling of the face or throat, dizziness leading to fainting, sudden loss of kidney function, or irregular heart rhythms.

The combination should be avoided in patients with known hypersensitivity to either component, severe renal impairment, hyperkalemia, or in women who are pregnant. Caution is also advised for individuals with a history of angioedema or significant electrolyte disturbances.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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