Product image of Olmesartan Medoxomilo + Hidroclorotiazida Azevedos (Olmesartan Medoxomil, Hydrochlorothiazide) supplied by GNH India

Olmesartan Medoxomilo + Hidroclorotiazida Azevedos

Active Ingredient:
Olmesartan Medoxomil, Hydrochlorothiazide
Origin:
EU

Olmesartan Medoxomilo + Hidroclorotiazida Azevedos (Olmesartan Medoxomil, Hydrochlorothiazide)

Olmesartan medoxil, the active ingredient in Olmesartan Medoxomilo + Hidroclorotiazida Azevedos, is an angiotensin II receptor blocker presented as a oral tablet for hypertension management in adults. It combines olmesartan medoxil with hydrochlorothiazide to enhance blood pressure control.

GNH India supplies Olmesartan Medoxomilo + Hidroclorotiazida Azevedos as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

Manufacturer / TM Owner

Laboratórios Azevedos - Indústria Farmacêutica, S.A.

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Indications & Clinical Uses

Olmesartan medoxil/hydrochlorothiazide is indicated for cardiovascular conditions that involve elevated blood pressure.

  • Hypertension: helps lower systolic and diastolic blood pressure to reduce cardiovascular risk.
  • Hypertensive heart disease: assists in decreasing cardiac workload and preventing disease progression.
  • Chronic kidney disease with hypertension: aids in slowing renal function decline associated with high blood pressure.

How It Works

  • Olmesartan medoxil selectively blocks the AT1 subtype of angiotensin II receptors, preventing vasoconstriction and aldosterone release. Hydrochlorothiazide acts on the distal convoluted tubule to inhibit sodium‑chloride reabsorption, promoting diuresis. The combined effect reduces intravascular volume and systemic vascular resistance, leading to lowered arterial pressure.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Fatigue
  • Increased urination
  • Electrolyte disturbances (e.g., low potassium)

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis)
  • Acute kidney injury
  • Significant drop in blood pressure (hypotension)
  • Elevated liver enzymes
  • Angio‑edema involving the face or throat

Precautions & Warnings

When prescribing olmesartan medoxil/hydrochlorothiazide, clinicians should consider several safety aspects.

  • Renal function: assess baseline kidney function and monitor periodically.
  • Electrolytes: check serum potassium and sodium levels, especially in patients on other diuretics.
  • Pregnancy: contraindicated in the second and third trimesters due to fetal toxicity.
  • Elderly patients: start with lower doses and monitor for orthostatic hypotension.
  • Drug interactions: review concomitant medications for additive blood‑pressure effects.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Olmesartan medoxil/hydrochlorothiazide may interact with several drug classes.

Major Interactions (Avoid)

  • Aliskiren (in diabetic patients): risk of renal impairment and hyperkalemia.
  • Potassium‑sparing diuretics or supplements: may cause dangerous hyperkalemia.
  • Lithium: increased lithium levels and toxicity risk.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may reduce antihypertensive efficacy and affect renal function.
  • ACE inhibitors or other ARBs: additive hypotensive effect, monitor blood pressure.
  • Antidiabetic drugs: may enhance glucose‑lowering effect, requiring dose adjustment.

Frequently Asked Questions

Olmesartan Medoxomilo + Hidroclorotiazida Azevedos is a fixed‑dose combination of olmesartan medoxil and hydrochlorothiazide used to treat high blood pressure and to help protect the kidneys in patients with hypertension‑related chronic kidney disease.

Olmesartan medoxil blocks the AT1 receptors for angiotensin II, preventing the hormone from causing blood vessels to narrow and reducing aldosterone‑driven fluid retention. This results in vasodilation and lower blood pressure.

The dose is individualized by the prescribing clinician based on the patient’s blood‑pressure readings, kidney function and response to therapy. The prescriber determines the appropriate strength and dosing schedule.

Olmesartan medoxil is contraindicated in the second and third trimesters of pregnancy because of risk to the fetus. Safety during breastfeeding has not been established, so use is generally discouraged unless the benefit outweighs potential risk.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The olmesartan‑hydrochlorothiazide combo offers both ARB‑mediated vasodilation and thiazide‑diuretic‑induced volume reduction, often providing greater blood‑pressure control than either component alone. Compared with ACE‑inhibitor‑diuretic combos, it avoids cough and may have a more favorable metabolic profile.

Store the tablets at ambient temperature, below 25 °C, in the original container, protected from moisture and direct sunlight.

The medication is taken orally, usually once daily, with or without food, as directed by the prescriber. Patients should follow the exact dosing instructions provided on the prescription label.

Serious risks include severe allergic reactions such as anaphylaxis, acute kidney injury, marked hypotension and angio‑edema. Patients should seek immediate medical attention if they experience swelling of the face or throat, sudden dizziness, or a rapid decline in kidney function.

Individuals with known hypersensitivity to olmesartan, hydrochlorothiazide or any component of the formulation should avoid it. It is also contraindicated in pregnant women (second and third trimesters) and should be used with caution in patients with severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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