Product image of Olmetec Plus (Olmesartan Medoxomil, Hydrochlorothiazide) supplied by GNH India

Olmetec Plus

Active Ingredient:
Olmesartan Medoxomil, Hydrochlorothiazide
Origin:
EU

Olmetec Plus (Olmesartan Medoxomil, Hydrochlorothiazide)

Olmesartan medoxomil, the active ingredient in Olmetec Plus, is an angiotensin II receptor blocker combined with a thiazide diuretic presented as a tablet for oral use. It treats hypertension and is indicated for adults who require blood pressure control.

GNH India supplies Olmetec Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pharmaserve Hellas S.A.C.I

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Indications & Clinical Uses

Olmetec Plus is an antihypertensive agent that works within the renin‑angiotensin‑aldosterone system to lower blood pressure.

  • Essential hypertension: helps achieve target blood pressure levels in patients with primary high blood pressure.
  • Hypertension with volume overload: provides additional diuretic effect to reduce fluid retention.
  • Hypertension in diabetic patients: assists in blood pressure control while offering renal protective benefits.

How It Works

  • Olmesartan medoxomil blocks the binding of angiotensin II to the AT1 receptor on vascular smooth‑muscle and adrenal cells, preventing vasoconstriction and aldosterone release. Hydrochlorothiazide inhibits sodium‑chloride reabsorption in the distal convoluted tubule, promoting diuresis and further reducing circulating volume, together producing a synergistic antihypertensive effect.

Side Effects

Olmetec Plus may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Fatigue
  • Increased urination
  • Electrolyte disturbances (e.g., low potassium)
  • Mild gastrointestinal discomfort

Serious or Rare Side Effects

  • Severe hypotension
  • Acute kidney injury
  • Hyperkalemia
  • Angio‑edema
  • Liver enzyme elevation
  • Blood dyscrasias such as agranulocytosis

Precautions & Warnings

When prescribing Olmetec Plus, clinicians should consider several safety aspects.

  • Renal function monitoring: assess serum creatinine and eGFR before and during therapy.
  • Electrolyte balance: check potassium and sodium levels regularly.
  • Pregnancy: avoid use, especially in the second and third trimesters.
  • Concomitant NSAIDs: monitor for reduced antihypertensive effect and renal impairment.
  • Gout history: use cautiously as thiazides may increase uric acid.

Store at ambient temperature: keep below 25°C in the original container, protect from moisture and light.

Avoid Interactions

Olmetec Plus can interact with several drug classes, requiring attention to dosing and monitoring.

Major Interactions (Avoid)

  • Aliskiren: combined use may cause excessive hypotension and renal dysfunction.
  • Lithium: risk of lithium toxicity due to reduced renal clearance.
  • Potassium‑saving diuretics or supplements: may precipitate hyper‑kalemia.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may blunt antihypertensive response and affect renal function.
  • ACE inhibitors or other ARBs: additive blood‑pressure lowering effect, risk of hyper‑kalemia.
  • Antidiabetic agents: may enhance hypoglycaemic effect, requiring dose adjustment.

Frequently Asked Questions

Olmetec Plus is a fixed‑dose combination of olmesartan medoxomil and hydrochlorothiazide indicated for the treatment of hypertension. It is prescribed to lower elevated blood pressure in adults, including patients who need additional diuretic therapy to manage fluid retention.

Olmesartan medoxomil is an angiotensin II receptor blocker that selectively inhibits the AT‑1 receptor, preventing angiotensin‑II‑induced vasoconstriction and aldosterone release. This results in relaxed blood vessels and reduced sodium‑water retention, helping to lower blood pressure.

The dose of Olmetec Plus is individualized by the prescribing clinician based on the patient’s blood‑pressure profile, renal function and response to therapy. The prescriber determines the appropriate strength and dosing schedule.

Olmesartan medoxomil is contraindicated in pregnancy, especially during the second and third trimesters, due to the risk of fetal toxicity. Safety during breastfeeding has not been established, so the product should be used only if the potential benefit outweighs the risk.

To order Olmetec Plus, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Olmetec Plus combines an ARB with a thiazide diuretic, offering dual mechanisms that can provide more effective blood‑pressure reduction than either component alone. Compared with monotherapy ARBs or diuretics, the combination may achieve target pressures with a single tablet, improving adherence.

Olmetec Plus tablets should be stored at ambient temperature, below 25 °C, in the original packaging. Keep the container tightly closed, protect from moisture and light, and store out of reach of children.

Olmetec Plus is taken orally, usually once daily, with or without food, as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not chewed or crushed.

Serious risks include severe hypotension, acute kidney injury, hyper‑kalemia, angio‑edema and rare blood disorders such as agranulocytosis. Patients should be monitored for signs of these conditions, especially during treatment initiation or dose changes.

Olmetec Plus is contraindicated in patients with known hypersensitivity to olmesartan, hydrochlorothiazide or any excipients, in pregnant women, and in individuals with severe renal impairment or hyper‑kalemia. Caution is advised for those with hepatic disease or a history of angio‑edema.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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