Product image of Olmetec Plus (Olmesartan Medoxomil, Hydrochlorothiazide) supplied by GNH India

Olmetec Plus

Active Ingredient:
Olmesartan Medoxomil, Hydrochlorothiazide
Origin:
EU

Olmetec Plus (Olmesartan Medoxomil, Hydrochlorothiazide)

Olmesartan medoxomil, the active ingredient in Olmetec Plus, is an angiotensin II receptor blocker combined with a thiazide diuretic presented as a tablet for oral use. It treats hypertension and is indicated for adults who require blood pressure control.

GNH India supplies Olmetec Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Daiichi Sankyo Belgium S.A

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Indications & Clinical Uses

Olmetec Plus is an antihypertensive medication that acts on the renin‑angiotensin‑aldosterone system to lower blood pressure.

  • Hypertension: helps achieve target blood pressure levels in patients with primary hypertension.
  • Hypertension with fluid retention: provides additional diuretic effect to reduce edema.
  • High‑risk cardiovascular patients: contributes to overall cardiovascular risk reduction when combined with lifestyle measures.

How It Works

  • Olmesartan medoxomil blocks the binding of angiotensin II to the AT‑1 receptor on vascular smooth‑muscle and adrenal cells, preventing vasoconstriction and aldosterone release. Hydrochlorothiazide inhibits sodium‑chloride reabsorption in the distal convoluted tubule, promoting diuresis and reducing plasma volume. The combined actions produce additive blood‑pressure‑lowering effects.

Side Effects

Olmetec Plus may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Fatigue
  • Increased urination
  • Electrolyte disturbances (e.g., low potassium)
  • Mild gastrointestinal discomfort

Serious or Rare Side Effects

  • Severe hypotension
  • Acute kidney injury
  • Hyperkalemia
  • Angio‑edema
  • Liver function abnormalities
  • Blood dyscrasias (e.g., agranulocytosis)

Precautions & Warnings

Before initiating therapy with Olmetec Plus, consider the following precautions:

  • Renal function: assess baseline kidney function and monitor periodically.
  • Electrolytes: check serum potassium and sodium levels, especially in patients on other diuretics.
  • Pregnancy: avoid use during pregnancy due to risk of fetal toxicity.
  • Elderly patients: start at lower dose and monitor for orthostatic hypotension.
  • Drug interactions: review concomitant medications for potential additive blood‑pressure effects.
  • Store at ambient temperature: keep below 25°C, retain in original packaging and protect from moisture.

Avoid Interactions

Olmetec Plus can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Aliskiren: combined use may cause excessive hypotension and renal impairment.
  • Lithium: risk of lithium toxicity may increase.
  • NSAIDs: may blunt antihypertensive effect and worsen renal function.

Moderate Interactions (Monitor Closely)

  • Other antihypertensives: may require dose adjustment to avoid hypotension.
  • Potassium‑sparing diuretics or supplements: risk of hyperkalemia.
  • ACE inhibitors: additive risk of angio‑edema and renal dysfunction.

Frequently Asked Questions

Olmetec Plus is a fixed‑dose combination of olmesartan medoxomil and hydrochlorothiazide used to lower high blood pressure in adults, including patients who need an added diuretic effect to control fluid retention.

Olmesartan medoxomil is an angiotensin II receptor blocker that selectively inhibits the AT‑1 receptor, preventing angiotensin‑II‑induced vasoconstriction and aldosterone release, which helps relax blood vessels and lower blood pressure.

The prescribed dose of Olmetec Plus is determined by the treating physician based on the patient’s blood‑pressure readings, renal function and overall clinical profile. Dosage adjustments are made according to individual response and tolerability.

Olmetec Plus is contraindicated in pregnancy because olmesartan can cause fetal toxicity. It should be used only if the potential benefit justifies the risk. Limited data are available for breastfeeding; the drug may pass into milk, so a healthcare professional should evaluate the risk‑benefit ratio.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Olmetec Plus combines an ARB with a thiazide diuretic, offering dual mechanisms that can be more effective than monotherapy for patients needing both vasodilation and volume reduction. Compared with ACE‑inhibitor + diuretic combos, it has a lower incidence of cough but a similar risk profile for hyperkalemia and renal effects.

Store tablets at ambient temperature, below 25 °C, in the original container to protect from moisture and light. Keep out of reach of children and do not use after the expiry date printed on the packaging.

Olmetec Plus is taken orally, usually once daily, with or without food, as directed by a healthcare professional. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed.

Serious adverse events include severe hypotension, acute kidney injury, hyperkalemia, angio‑edema and liver function abnormalities. Patients should seek immediate medical attention if they experience swelling of the face or throat, sudden dizziness, or marked changes in urine output.

Olmetec Plus should be avoided in patients with known hypersensitivity to olmesartan, hydrochlorothiazide or any component of the formulation, in pregnant women, and in individuals with severe renal impairment or electrolyte disturbances unless closely monitored.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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