Product image of Olmetec Plus (Olmesartan Medoxomil, Hydrochlorothiazide) supplied by GNH India

Olmetec Plus

Active Ingredient:
Olmesartan Medoxomil, Hydrochlorothiazide
Origin:
EU

Olmetec Plus (Olmesartan Medoxomil, Hydrochlorothiazide)

Olmesartan medoxomil, the active ingredient in Olmetec Plus, is an Angiotensin II receptor blocker presented as an oral tablet for systemic use. It is combined with hydrochlorothiazide, a thiazide diuretic, to treat hypertension in adult patients.

GNH India supplies Olmetec Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Daiichi Sankyo Uk Ltd

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Indications & Clinical Uses

Olmetec Plus, an ARB‑thiazide combination, is indicated for the management of high blood pressure.

  • Hypertension (essential): lowers systolic and diastolic pressure, reducing cardiovascular risk.
  • Hypertension requiring diuretic therapy: adds fluid‑removing effect to improve blood pressure control.
  • Hypertension with fluid retention: provides combined vasodilation and diuresis for better therapeutic outcome.

How It Works

  • Olmesartan medoxomil selectively blocks AT1 receptors, preventing angiotensin II‑mediated vasoconstriction and aldosterone release, while hydrochlorothiazide inhibits Na⁺/Cl⁻ reabsorption in the distal convoluted tubule, increasing urinary sodium and water excretion. The dual action reduces peripheral resistance and blood volume, resulting in lowered arterial pressure.

Side Effects

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Increased urination or thirst
  • Fatigue
  • Mild electrolyte disturbances (e.g., low potassium)
  • Dry mouth

Serious or Rare Side Effects

  • Severe hypotension
  • Acute kidney injury or worsening renal function
  • Hyperkalemia or severe electrolyte imbalance
  • Allergic reactions such as rash or angioedema
  • Pancreatitis
  • Blood dyscrasias (e.g., agranulocytosis)

Precautions & Warnings

Olmetec Plus should be used with caution in several clinical situations.

  • Renal function: monitor serum creatinine and potassium regularly.
  • Electrolyte balance: check sodium and potassium levels, especially in patients on other diuretics.
  • Pregnancy: avoid unless benefits outweigh potential risks.
  • Concomitant NSAIDs: may diminish antihypertensive effect and affect renal function.
  • Volume depletion: use cautiously in patients with hypovolemia or on high‑dose diuretics.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Olmetec Plus may interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Aliskiren in patients with diabetes: increased risk of renal impairment.
  • Potassium‑sparing diuretics or supplements: risk of hyperkalemia.
  • Lithium: heightened lithium toxicity.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may blunt antihypertensive response.
  • ACE inhibitors or other ARBs: additive effect on potassium levels.
  • Cyclosporine or tacrolimus: may raise serum creatinine.

Frequently Asked Questions

Olmetec Plus is prescribed to lower high blood pressure (hypertension). It combines an angiotensin II receptor blocker with a thiazide diuretic to provide both vasodilation and fluid removal, helping to achieve target blood‑pressure levels and reduce the risk of cardiovascular events.

Olmesartan medoxomil blocks the AT1 receptors that normally bind angiotensin II. By preventing this binding, it stops angiotensin‑II‑induced vasoconstriction and aldosterone release, leading to relaxed blood vessels and reduced sodium‑water retention, which together lower arterial pressure.

The specific dose of Olmetec Plus is determined by the prescribing clinician based on the patient’s blood‑pressure readings, kidney function, and other individual factors. Only a qualified health professional should set the dosage and adjust it as needed.

Safety of Olmetec Plus in pregnancy has not been established, and it is generally avoided unless the potential benefit justifies the risk. Limited data are available for breastfeeding; therefore, a healthcare provider should evaluate the risk‑benefit ratio before use.

To order Olmetec Plus, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Olmetec Plus offers a dual mechanism—angiotensin II blockade plus thiazide‑induced diuresis—providing more potent blood‑pressure reduction than many single‑agent therapies. Compared with ACE inhibitors, it has a lower incidence of cough, and compared with beta‑blockers, it does not affect heart rate. Choice of therapy depends on patient comorbidities and tolerance.

Store Olmetec Plus at ambient temperature, below 25 °C, in its original packaging. Keep the tablets away from moisture, direct sunlight, and excessive heat. Do not use if the packaging is damaged or if the tablets appear discolored.

Olmetec Plus is taken orally, usually once daily, with a full glass of water. It may be taken with or without food, but consistent timing each day helps maintain stable blood‑pressure control. Swallow the tablet whole; do not crush or chew unless instructed by a healthcare professional.

Serious risks include severe hypotension, acute kidney injury, marked electrolyte disturbances such as hyperkalemia, and rare allergic reactions like angioedema. Patients should be monitored for sudden drops in blood pressure, changes in kidney function, and any signs of rash or swelling, and seek medical attention promptly if they occur.

Olmetec Plus is contraindicated in patients with known hypersensitivity to olmesartan, hydrochlorothiazide, or any component of the formulation. It should also be avoided in individuals with severe renal impairment, anuria, or those who are pregnant unless the benefit outweighs the risk. Clinicians must assess each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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